Q6P9K9 · NRX3A_MOUSE

  • Protein
    Neurexin-3
  • Gene
    Nrxn3
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling (By similarity).

Features

Showing features for binding site.

115712004006008001,0001,2001,400
TypeIDPosition(s)Description
Binding site304Ca2+ 1 (UniProtKB | ChEBI)
Binding site321Ca2+ 1 (UniProtKB | ChEBI)
Binding site374Ca2+ 1 (UniProtKB | ChEBI)
Binding site732Ca2+ 2 (UniProtKB | ChEBI)
Binding site749Ca2+ 2 (UniProtKB | ChEBI)
Binding site807Ca2+ 2 (UniProtKB | ChEBI)
Binding site1142Ca2+ 3 (UniProtKB | ChEBI)
Binding site1159Ca2+ 3 (UniProtKB | ChEBI)
Binding site1241Ca2+ 3 (UniProtKB | ChEBI)
Binding site1243Ca2+ 3 (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcell projection
Cellular ComponentGABA-ergic synapse
Cellular Componentglutamatergic synapse
Cellular Componentpresynaptic active zone membrane
Cellular Componentpresynaptic membrane
Cellular Componentprotein-containing complex
Molecular Functioncalcium channel regulator activity
Molecular Functionmetal ion binding
Biological Processcell adhesion
Biological Processchemical synaptic transmission
Biological Processneurotransmitter receptor localization to postsynaptic specialization membrane
Biological Processneurotransmitter secretion
Biological Processpostsynaptic density assembly
Biological Processpresynaptic modulation of chemical synaptic transmission
Biological Processregulation of postsynaptic membrane neurotransmitter receptor levels
Biological Processsynapse assembly
Biological Processtrans-synaptic signaling
Biological Processtrans-synaptic signaling, modulating synaptic transmission

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Neurexin-3
  • Alternative names
    • Neurexin III-alpha
    • Neurexin-3-alpha

Gene names

    • Name
      Nrxn3

Organism names

  • Taxonomic identifier
  • Strain
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q6P9K9
  • Secondary accessions
    • E9PW93
    • E9Q466
    • Q8CCT8

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain28-1496Extracellular
Transmembrane1497-1517Helical
Topological domain1518-1571Cytoplasmic

Keywords

PTM/Processing

Features

Showing features for signal, chain, glycosylation, disulfide bond.

TypeIDPosition(s)Description
Signal1-27
ChainPRO_000041255728-1571Neurexin-3
Glycosylation58N-linked (GlcNAc...) asparagine
Glycosylation105N-linked (GlcNAc...) asparagine
Disulfide bond202↔213
Disulfide bond207↔222
Disulfide bond224↔234
Disulfide bond404↔440
Disulfide bond610↔639
Disulfide bond647↔658
Disulfide bond652↔667
Disulfide bond669↔679
Glycosylation757N-linked (GlcNAc...) asparagine
Disulfide bond1018↔1046
Disulfide bond1053↔1064
Disulfide bond1058↔1073
Disulfide bond1075↔1085
Glycosylation1189N-linked (GlcNAc...) asparagine
Glycosylation1287N-linked (GlcNAc...) asparagine
Glycosylation1331N-linked (GlcNAc...) asparagine
Glycosylation1347O-linked (Xyl...) (heparan sulfate) serine

Post-translational modification

O-glycosylated; contains heparan sulfate. Heparan sulfate attachment is required for synapse development by mediating interactions with neuroligins.

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Brain and arteries (at protein level).

Gene expression databases

Interaction

Subunit

The laminin G-like domain 2 binds to NXPH1 (By similarity).
Specific isoforms bind to alpha-dystroglycan (By similarity).
The cytoplasmic C-terminal region binds to CASK (By similarity).
Specific isoforms bind neuroligins NLGN1, NLGN2 and NLGN3 (By similarity).
Interacts with CLSTN3 (PubMed:24094106, PubMed:24613359, PubMed:32434929).

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
XENO Q6P9K9PTPRT O145222EBI-7281557, EBI-728180

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for domain, compositional bias, region.

TypeIDPosition(s)Description
Domain28-202Laminin G-like 1
Domain198-235EGF-like 1
Domain258-440Laminin G-like 2
Domain447-639Laminin G-like 3
Domain643-680EGF-like 2
Domain685-857Laminin G-like 4
Domain871-1046Laminin G-like 5
Domain1049-1086EGF-like 3
Domain1090-1290Laminin G-like 6
Compositional bias1324-1347Polar residues
Region1324-1348Disordered
Region1539-1571Disordered
Compositional bias1553-1571Basic and acidic residues

Sequence similarities

Belongs to the neurexin family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoforms

Align isoforms (3)
  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.

This entry describes 3 isoforms produced by Alternative promoter usage & Alternative splicing. A number of isoforms, alpha-type and beta-type are produced by alternative promoter usage. Beta-type isoforms differ from alpha-type isoforms in their N-terminus.

Q6P9K9-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    1,571
  • Mass (Da)
    173,428
  • Last updated
    2011-12-14 v2
  • Checksum
    98F989F5DD2B71AB
MSFTLHSVFFTLKVSIFLGSLVGLCLGLEFMGLPNQWARYLRWDASTRSDLSFQFKTNVSTGLLLYLDDGGVCDFLCLSLVDGRVQLRFSMDCAETTVLSNKQVNDSSWHFLMVSRDRVRTGLVIDGEGQSGELRPQRPYMDVVSDLFLGGVPADIRPSALTLDGVQSMPGFKGLMLDLKYGNSEPRLLGSQSVQLEAEGPCGERPCENGGICFLLDGHPTCDCSTTGYGGTLCSEDVSQGPGLSHLMMSEQAREENVATFRGSEYLCYDLSQNPIQSSSDEITLSFKTWQRNGLILHTGKSADYVNLALKDGAVSLVINLGSGAFEAIVEPVNGKFNDNAWHDVKVTRNLRQVTISVDGILTTTGYTQEDYTMLGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKEVVYKNNDIRLELSRLARIGDTKMKIYGEVVFKCENVATLDPINFETPEAYISLPKWNTKRMGSISFDFRTTEPNGLILFTHGKPQERKDVRSQKNTKVDFFAVELLDGNLYLLLDMGSGTIKVKATQKKANDGEWYHVDIQRDGRSGTISVNSRRTPFTASGESEILDLEGDMYLGGLPENRAGLILPTELWTAMLNYGYVGCIRDLFIDGRSKNIRQLAEMQNAAGVKSSCSRMSAKQCDSYPCKNNAVCKDGWNRFICDCTGTGYWGRTCEREASILSYDGSMYMKVIMPMVMHTEAEDVSFRFMSQRAYGLLVATTSRDSADTLRLELDGGRVKLMVNLDCIRINCNSSKGPETLYAGQKLNDNEWHTVRVVRRGKSLKLTVDDDVAEGTMVGDHTRLEFHNIETGIMTEKRYISVVPSSFIGHLQSLMFNGLLYIDLCKNGDIDYCELKARFGLRNIIADPVTFKTKSSYLTLATLQAYTSMHLFFQFKTTSADGFILFNSGDGNDFIAVELVKGYIHYVFDLGNGPNVIKGNSDRPLNDNQWHNVVITRDSSNTHSLKVDTKVVTQVINGAKNLDLKGDLYMAGLAQGMYSNLPKLVASRDGFQGCLASVDLNGRLPDLINDALHRSGQIERGCEGPSTTCQEDSCANQGVCMQQWEGFTCDCSMTSYSGNQCNDPGATYIFGKSGGLILYTWPANDRPSTRSDRLAVGFSTTVKDGILVRIDSAPGLGDFLQLHIEQGKIGVVFNIGTVDISIKEERTPVNDGKYHVVRFTRNGGNATLQVDNWPVNEHYPTGNTDNERLQMVKQKIPFKYNRPVEEWLQEKGRQLTIFNTQAQIAIGGKDKGRLFQGQLSGLYYDGLKVLNMAAENNPNIKINGSVRLVGEVPSVSGTTQTTSMPPEMSTTVMETTTTMATTTTRKNRSTASIQPTSDDLVSSAECSSDDEDFVECEPSTDKSLSTSIFEGGYKAHAPKWESKDFRPNKVSETSRTTTTSLSPELIRFTASSSSGMVPKLPAGKMNNRDLKPQPDIVLLPLPTAYELDSTKLKSPLITSPMFRNVPTANPTEPGIRRVPGASEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYQVDETRNYISNSAQSNGTLMKEKQASSKSGHKKQKNKDKEYYV

Q6P9K9-2

  • Name
    2a
  • Note
    Produced by alternative splicing.
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Q8C985-1

The sequence of this isoform can be found in the external entry linked below. Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

View isoform

Computationally mapped potential isoform sequences

There are 5 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
E9Q3Q4E9Q3Q4_MOUSENrxn3430
E9Q2X2E9Q2X2_MOUSENrxn31391
A0A5F8MPQ9A0A5F8MPQ9_MOUSENrxn3635
Q8C985NRX3B_MOUSENrxn3567
A0A087WPQ9A0A087WPQ9_MOUSENrxn31009

Sequence caution

The sequence AAH60719.1 differs from that shown. Reason: Miscellaneous discrepancy Contains an insert which is not supported by any other transcript and which does not match with the genome.

Features

Showing features for alternative sequence, sequence conflict, compositional bias.

TypeIDPosition(s)Description
Alternative sequenceVSP_0417101-373in isoform 2a
Sequence conflict390in Ref. 1; BAC27716
Alternative sequenceVSP_0417111047in isoform 2a
Compositional bias1324-1347Polar residues
Alternative sequenceVSP_0417121364-1470in isoform 2a
Compositional bias1553-1571Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AK032126
EMBL· GenBank· DDBJ
BAC27716.1
EMBL· GenBank· DDBJ
mRNA
AC115709
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC115744
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC115910
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC120383
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC154495
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC155231
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC155274
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC156637
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC161049
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC171335
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
CAAA01025627
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
CR974428
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
CR974583
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
CT009613
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
CT009725
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
CT010588
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
CU041252
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
BC060719
EMBL· GenBank· DDBJ
AAH60719.1
EMBL· GenBank· DDBJ
mRNA Sequence problems.

Genome annotation databases

Similar Proteins

Disclaimer

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