Q6P9I7 · SMC6_XENLA
- ProteinStructural maintenance of chromosomes protein 6
- Genesmc6
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids1128 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
function
Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components (By similarity).
Features
Showing features for binding site.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | chromosome, telomeric region | |
Cellular Component | PML body | |
Cellular Component | Smc5-Smc6 complex | |
Molecular Function | ATP binding | |
Biological Process | cellular senescence | |
Biological Process | DNA repair | |
Biological Process | telomere maintenance via recombination |
Keywords
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameStructural maintenance of chromosomes protein 6
- Short namesSMC protein 6; SMC-6; xSMC6
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Amphibia > Batrachia > Anura > Pipoidea > Pipidae > Xenopodinae > Xenopus > Xenopus
Accessions
- Primary accessionQ6P9I7
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Note: Associates with chromatin.
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000270959 | 1-1128 | Structural maintenance of chromosomes protein 6 | |||
Sequence: MGKRKDGSPIAPSSQRKKQRQEVDDPYDEEDYGQAGPSVSNDYGQRKKQRKEADNSHTDSDYENSVSCASSQRVSASQSGTGDVGIIESIFLRNFMCHSMLGPFRFGPNVNFVIGNNGSGKSAVLTALIVGLGGKAAITNRGSSIKGFVKEGQTFAEISITLRNRGQDAYKPDVFGNSITVQQRLTTDGSRTYKLKSATGAVVSNKKEELTAILDHFNIQVDNPVSVLTQEMSKHFLQSKNESDKYKFFMKATQLEQMKEDYSYIMETKSRTHDQVENGGERLRDLRQECIQKEERFKSIASLGEMKEKLEDLKNKMAWALVTESEKQIKPFIEQISTEEGRTVKYEQKIEECQGKVINAEEKFRAKQEELDKITQEAVALKPQGIGLKEDVQKKRKSYNESEVLYNRHRMELKRLERDAEQLHKRIEELKKSADNDSESEKMARQKEINQIRERMKALHDKDITTNQQIHQFQQAIEKYKEERARIGNEERNIKQRLEQHKRQLKELHESKTDRLKRFGQNMPALLAAIDEADKLGRFRKKPVGPLGACIHLKDQELALAVESCLKGLMFAFCCDNHQDERMLQNIMSREYPRGRRPQIIVNEFIDHVYDVRQRATFHPDHPTVLTALEIDHPVVTNCLIDMRGIETILIIKGKDEAREIMQKRAPPRNCREAFTGEGDQVYTNRYYSSDSRRATLLSRDVEAEISHLEKELRNFGSQMATFQQRAQSVDKDIKENEGILRQYHNSKKQIQIDLRPLLERISELENVEEQPSIDIATLEGEAEENLNKIELVKQEVELAKEKMGNLKSFLTTAEINYEEIKKKISSVAEVAEPVKEDLHRVDQEVENCKRHRKHYEEKLKEHLDRIQKRKEEVAAKEQELEVKISQAKCICPERIEVSRTARSLDTEINRLREKINSEEVLHGNREEIIKQYHEAKERYQDVEGKVKHLKRFIKLLDEIMAQRYKSYQQFRRCLTFRCKIYFDSLLSQRAYSGKINFDHKNETLSITVQPGEGNKAALSDMKCLSGGERSFSTVCFILSLWSIAESPFRCLDEFDVYMDMVNRRISMDMMLSMADSQRFRQFILLTPQNMSSLPSTSLVRILRMKDPERGQTTLPFQPLNQEAEDEE |
Expression
Developmental stage
Loaded onto chromatin during DNA replication in a manner dependent on the initiation of DNA synthesis, and it dissociated from chromatin during mitosis. Chromatin loading is not induced by DNA double-strand breaks.
Gene expression databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, coiled coil.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-80 | Disordered | ||||
Sequence: MGKRKDGSPIAPSSQRKKQRQEVDDPYDEEDYGQAGPSVSNDYGQRKKQRKEADNSHTDSDYENSVSCASSQRVSASQSG | ||||||
Compositional bias | 44-59 | Basic and acidic residues | ||||
Sequence: GQRKKQRKEADNSHTD | ||||||
Compositional bias | 60-80 | Polar residues | ||||
Sequence: SDYENSVSCASSQRVSASQSG | ||||||
Coiled coil | 275-519 | |||||
Sequence: QVENGGERLRDLRQECIQKEERFKSIASLGEMKEKLEDLKNKMAWALVTESEKQIKPFIEQISTEEGRTVKYEQKIEECQGKVINAEEKFRAKQEELDKITQEAVALKPQGIGLKEDVQKKRKSYNESEVLYNRHRMELKRLERDAEQLHKRIEELKKSADNDSESEKMARQKEINQIRERMKALHDKDITTNQQIHQFQQAIEKYKEERARIGNEERNIKQRLEQHKRQLKELHESKTDRLKRF | ||||||
Region | 520-692 | Flexible hinge | ||||
Sequence: GQNMPALLAAIDEADKLGRFRKKPVGPLGACIHLKDQELALAVESCLKGLMFAFCCDNHQDERMLQNIMSREYPRGRRPQIIVNEFIDHVYDVRQRATFHPDHPTVLTALEIDHPVVTNCLIDMRGIETILIIKGKDEAREIMQKRAPPRNCREAFTGEGDQVYTNRYYSSDS | ||||||
Coiled coil | 693-955 | |||||
Sequence: RRATLLSRDVEAEISHLEKELRNFGSQMATFQQRAQSVDKDIKENEGILRQYHNSKKQIQIDLRPLLERISELENVEEQPSIDIATLEGEAEENLNKIELVKQEVELAKEKMGNLKSFLTTAEINYEEIKKKISSVAEVAEPVKEDLHRVDQEVENCKRHRKHYEEKLKEHLDRIQKRKEEVAAKEQELEVKISQAKCICPERIEVSRTARSLDTEINRLREKINSEEVLHGNREEIIKQYHEAKERYQDVEGKVKHLKRFIK |
Domain
The flexible hinge domain, which separates the large intramolecular coiled coil regions, allows the heterotypic interaction with the corresponding domain of SMC5, forming a V-shaped heterodimer.
Sequence similarities
Belongs to the SMC family. SMC6 subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,128
- Mass (Da)130,513
- Last updated2004-07-05 v1
- Checksum126806396112F088
Features
Showing features for compositional bias, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 44-59 | Basic and acidic residues | ||||
Sequence: GQRKKQRKEADNSHTD | ||||||
Sequence conflict | 58 | in Ref. 1; BAC56937 | ||||
Sequence: T → A | ||||||
Compositional bias | 60-80 | Polar residues | ||||
Sequence: SDYENSVSCASSQRVSASQSG | ||||||
Sequence conflict | 62 | in Ref. 1; BAC56937 | ||||
Sequence: Y → H | ||||||
Sequence conflict | 68 | in Ref. 1; BAC56937 | ||||
Sequence: C → F | ||||||
Sequence conflict | 755 | in Ref. 1; BAC56937 | ||||
Sequence: L → H | ||||||
Sequence conflict | 1023-1024 | in Ref. 1; BAC56937 | ||||
Sequence: KC → RS |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AB103031 EMBL· GenBank· DDBJ | BAC56937.1 EMBL· GenBank· DDBJ | mRNA | ||
BC060747 EMBL· GenBank· DDBJ | AAH60747.1 EMBL· GenBank· DDBJ | mRNA |