Q6P572 · Q6P572_MOUSE
- ProteinMyotubularin-related protein 2
- GeneMtmr2
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids571 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
Catalytic activity
- 1,2-dioctanoyl-sn-glycero-3-phospho-(1-D-myo-inositol-3-phosphate) + H2O = 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate
- 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + H2O = 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 258-261 | substrate | ||||
Sequence: NKAK | ||||||
Binding site | 283-284 | substrate | ||||
Sequence: NI | ||||||
Active site | 345 | Phosphocysteine intermediate | ||||
Sequence: C | ||||||
Binding site | 345-351 | substrate | ||||
Sequence: CSDGWDR |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | early endosome membrane | |
Molecular Function | phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity | |
Molecular Function | phosphatidylinositol-3-phosphate phosphatase activity | |
Biological Process | lipid metabolic process |
Keywords
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameMyotubularin-related protein 2
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ6P572
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Early endosome membrane ; Peripheral membrane protein
Endosome membrane ; Peripheral membrane protein
Keywords
- Cellular component
PTM/Processing
Proteomic databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 133-508 | Myotubularin phosphatase | ||||
Sequence: GWKLYDPLLEYRRQGIPNESWRITKINERYELCDTYPALLVVPANIPDEELKRVASFRSRGRIPVLSWIHPESQATVTRCSQPMVGVSGKRSKEDEKYLQAIMDSNAQSHKIFIFDARPSVNAVANKAKGGGYESEDAYQNAELVFLDIHNIHVMRESLRKLKEIVYPTIEETHWLSNLESTHWLEHIKLILAGALRIADKVESGKTSVVVHCSDGWDRTAQLTSLAMLMLDGYYRTIRGFEVLVEKEWLSFGHRFQLRVGHGDKNHADADRSPVFLQFIDCVWQMTRQFPTAFEFNEYFLITILDHLYSCLFGTFLCNSEQQRGKENLPKKTVSLWSYINSQLEDFTNPLYGSYSNHVLYPVASMRHLELWVGYY | ||||||
Domain | 314-361 | Tyrosine specific protein phosphatases | ||||
Sequence: THWLEHIKLILAGALRIADKVESGKTSVVVHCSDGWDRTAQLTSLAML | ||||||
Region | 542-571 | Disordered | ||||
Sequence: LQREISNRSTSSSERASSPAQCVTPVQTVV | ||||||
Compositional bias | 546-571 | Polar residues | ||||
Sequence: ISNRSTSSSERASSPAQCVTPVQTVV |
Sequence similarities
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length571
- Mass (Da)65,768
- Last updated2004-07-05 v1
- Checksum3A0872B069D5927A
Computationally mapped potential isoform sequences
There are 4 potential isoforms mapped to this entry
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 546-571 | Polar residues | ||||
Sequence: ISNRSTSSSERASSPAQCVTPVQTVV |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BC063050 EMBL· GenBank· DDBJ | AAH63050.1 EMBL· GenBank· DDBJ | mRNA |