Q6P4R8 · NFRKB_HUMAN

  • Protein
    Nuclear factor related to kappa-B-binding protein
  • Gene
    NFRKB
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Binds to the DNA consensus sequence 5'-GGGGAATCTCC-3'.
Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Modulates the deubiquitinase activity of UCHL5 in the INO80 complex.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular ComponentIno80 complex
Cellular Componentnucleoplasm
Cellular Componentnucleus
Molecular FunctionDNA binding
Molecular Functionprotease binding
Biological Processchromatin remodeling
Biological ProcessDNA recombination
Biological ProcessDNA repair
Biological Processpositive regulation of DNA repair
Biological Processpositive regulation of DNA-templated transcription
Biological Processpositive regulation of telomere maintenance in response to DNA damage
Biological Processregulation of cell cycle
Biological Processregulation of chromosome organization
Biological Processregulation of DNA repair
Biological Processregulation of DNA replication
Biological Processregulation of DNA strand elongation
Biological Processregulation of embryonic development
Biological Processtelomere maintenance

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Nuclear factor related to kappa-B-binding protein
  • Alternative names
    • DNA-binding protein R kappa-B
    • INO80 complex subunit G

Gene names

    • Name
      NFRKB
    • Synonyms
      INO80G

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q6P4R8
  • Secondary accessions
    • Q12869
    • Q15312
    • Q9H048

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Disease & Variants

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 1,525 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for chain, modified residue (large scale data), modified residue, cross-link.

TypeIDPosition(s)SourceDescription
ChainPRO_00002278071-1299UniProt
Modified residue (large scale data)176PRIDEPhosphoserine
Modified residue (large scale data)226PRIDEPhosphoserine
Modified residue228UniProtPhosphoserine
Modified residue (large scale data)228PRIDEPhosphoserine
Modified residue298UniProtPhosphoserine
Modified residue (large scale data)298PRIDEPhosphoserine
Cross-link327UniProtGlycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)
Modified residue (large scale data)328PRIDEPhosphoserine
Modified residue (large scale data)347PRIDEPhosphoserine
Modified residue351UniProtPhosphoserine
Modified residue (large scale data)351PRIDEPhosphoserine
Cross-link469UniProtGlycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)
Cross-link488UniProtGlycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternate
Cross-link488UniProtGlycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate
Modified residue (large scale data)494PRIDEPhosphoserine
Modified residue (large scale data)495PRIDEPhosphoserine
Modified residue (large scale data)499PRIDEPhosphothreonine
Modified residue (large scale data)799PRIDEPhosphoserine
Modified residue (large scale data)887PRIDEPhosphoserine
Modified residue (large scale data)899PRIDEPhosphothreonine
Modified residue1022UniProtPhosphoserine
Modified residue (large scale data)1022PRIDEPhosphoserine
Modified residue (large scale data)1034PRIDEPhosphoserine
Modified residue (large scale data)1035PRIDEPhosphothreonine
Modified residue1237UniProtN6-acetyllysine
Modified residue (large scale data)1288PRIDEPhosphothreonine
Modified residue1291UniProtPhosphoserine
Modified residue (large scale data)1291PRIDEPhosphoserine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed in thymus, brain, testes, spleen and liver.

Gene expression databases

Organism-specific databases

Interaction

Subunit

Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the N-terminus of INO80. Interacts with UCHL5; NFRKB competes with ADRM1 for interaction with UCHL5.

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY Q6P4R8UCHL5 Q9Y5K514EBI-2511210, EBI-1051183
BINARY Q6P4R8UCHL5 Q9Y5K5-33EBI-2511210, EBI-11749875
View interactors in UniProtKB
View CPX-846 in Complex Portal

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for domain, region, compositional bias.

TypeIDPosition(s)Description
Domain39-156DEUBAD
Region163-187Disordered
Region204-232Disordered
Compositional bias210-224Polar residues
Region370-495Winged-helix like domain
Region669-760Disordered
Compositional bias682-717Polar residues
Compositional bias718-738Pro residues
Compositional bias742-760Polar residues
Region882-902Disordered
Region1017-1043Disordered
Compositional bias1026-1043Polar residues

Domain

NFRKB seems to be mostly disordered. The wing-helix like domain doesn't bind DNA.

Sequence similarities

Belongs to the NFRKB family.

Phylogenomic databases

Family and domain databases

Sequence & Isoforms

Align isoforms (3)
  • Sequence status
    Complete

This entry describes 3 isoforms produced by Alternative splicing.

Q6P4R8-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    1,299
  • Mass (Da)
    139,001
  • Last updated
    2006-03-21 v2
  • Checksum
    087B212E283C3820
MDSLDHMLTDPLELGPCGDGHGTRIMEDCLLGGTRVSLPEDLLEDPEIFFDVVSLSTWQEVLSDSQREHLQQFLPQFPEDSAEQQNELILALFSGENFRFGNPLHIAQKLFRDGHFNPEVVKYRQLCFKSQYKRYLNSQQQYFHRLLKQILASRSDLLEMARRSGPALPFRQKRPSPSRTPEEREWRTQQRYLKVLREVKEECGDTALSSDEEDLSSWLPSSPARSPSPAVPLRVVPTLSTTDMKTADKVELGDSDLKIMLKKHHEKRKHQPDHPDLLTGDLTLNDIMTRVNAGRKGSLAALYDLAVLKKKVKEKEEKKKKKIKTIKSEAEDLAEPLSSTEGVAPLSQAPSPLAIPAIKEEPLEDLKPCLGINEISSSFFSLLLEILLLESQASLPMLEERVLDWQSSPASSLNSWFSAAPNWAELVLPALQYLAGESRAVPSSFSPFVEFKEKTQQWKLLGQSQDNEKELAALFQLWLETKDQAFCKQENEDSSDATTPVPRVRTDYVVRPSTGEEKRVFQEQERYRYSQPHKAFTFRMHGFESVVGPVKGVFDKETSLNKAREHSLLRSDRPAYVTILSLVRDAAARLPNGEGTRAEICELLKDSQFLAPDVTSTQVNTVVSGALDRLHYEKDPCVKYDIGRKLWIYLHRDRSEEEFERIHQAQAAAAKARKALQQKPKPPSKVKSSSKESSIKVLSSGPSEQSQMSLSDSSMPPTPVTPVTPTTPALPAIPISPPPVSAVNKSGPSTVSEPAKSSSGVLLVSSPTMPHLGTMLSPASSQTAPSSQAAARVVSHSGSAGLSQVRVVAQPSLPAVPQQSGGPAQTLPQMPAGPQIRVPATATQTKVVPQTVMATVPVKAQTTAATVQRPGPGQTGLTVTSLPATASPVSKPATSSPGTSAPSASTAAVIQNVTGQNIIKQVAITGQLGVKPQTGNSIPLTATNFRIQGKDVLRLPPSSITTDAKGQTVLRITPDMMATLAKSQVTTVKLTQDLFGTGGNTTGKGISATLHVTSNPVHAADSPAKASSASAPSSTPTGTTVVKVTPDLKPTEASSSAFRLMPALGVSVADQKGKSTVASSEAKPAATIRIVQGLGVMPPKAGQTITVATHAKQGASVASGSGTVHTSAVSLPSMNAAVSKTVAVASGAASTPISISTGAPTVRQVPVSTTVVSTSQAGKLPTRITVPLSVISQPMKGKSVVTAPIIKGNLGANLSGLGRNIILTTMPAGTKLIAGNKPVSFLTAQQLQQLQQQGQATQVRIQTVPASHLQQGTASGSSKAVSTVVVTTAPSPKQAPEQQ

Q6P4R8-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 1-1: M → MHVFVQSTCGEETM
    • 213-213: E → EATLDLQEQFSFE

Q6P4R8-3

  • Name
    3
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Computationally mapped potential isoform sequences

There are 6 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
E9PQ59E9PQ59_HUMANNFRKB987
E9PQB0E9PQB0_HUMANNFRKB122
E9PM88E9PM88_HUMANNFRKB92
E9PJE1E9PJE1_HUMANNFRKB46
E9PJG2E9PJG2_HUMANNFRKB188
E9PJU3E9PJU3_HUMANNFRKB147

Sequence caution

The sequence AAA17871.1 differs from that shown. Reason: Frameshift

Features

Showing features for alternative sequence, compositional bias, sequence conflict.

TypeIDPosition(s)Description
Alternative sequenceVSP_0175921in isoform 2
Compositional bias210-224Polar residues
Alternative sequenceVSP_017593213in isoform 2
Compositional bias682-717Polar residues
Alternative sequenceVSP_017594687in isoform 3
Compositional bias718-738Pro residues
Compositional bias742-760Polar residues
Compositional bias1026-1043Polar residues
Sequence conflict1178in Ref. 3; AAH63280
Sequence conflict1213in Ref. 3; AAH63280

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U08191
EMBL· GenBank· DDBJ
AAA17871.1
EMBL· GenBank· DDBJ
mRNA Sequence problems.
X80878
EMBL· GenBank· DDBJ
CAA56846.1
EMBL· GenBank· DDBJ
mRNA
BC063280
EMBL· GenBank· DDBJ
AAH63280.1
EMBL· GenBank· DDBJ
mRNA
AL512730
EMBL· GenBank· DDBJ
CAC21663.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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