Q6P4E1 · GOLM2_HUMAN

  • Protein
    Protein GOLM2
  • Gene
    GOLM2
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    4/5

Function

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular ComponentGolgi apparatus
Cellular Componentmembrane

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Protein GOLM2
  • Alternative names
    • Cancer susceptibility candidate gene 4 protein (CASC4)
    • Golgi membrane protein 2

Gene names

    • Name
      GOLM2
    • Synonyms
      CASC4
    • ORF names
      UNQ2573/PRO6308

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q6P4E1
  • Secondary accessions
    • B4DPZ6
    • G5E934
    • Q6UY45
    • Q96EM1

Proteomes

Organism-specific databases

Subcellular Location

Membrane
; Single-pass type II membrane protein

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-14Cytoplasmic
Transmembrane15-35Helical; Signal-anchor for type II membrane protein
Topological domain36-436Lumenal

Keywords

Disease & Variants

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 463 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for modified residue, chain, modified residue (large scale data).

TypeIDPosition(s)SourceDescription
Modified residue1UniProtN-acetylmethionine
ChainPRO_00002918431-436UniProtProtein GOLM2
Modified residue (large scale data)68PRIDEPhosphoserine
Modified residue233UniProtPhosphoserine
Modified residue (large scale data)233PRIDEPhosphoserine
Modified residue275UniProtPhosphoserine
Modified residue (large scale data)319PRIDEPhosphoserine
Modified residue328UniProtPhosphoserine
Modified residue (large scale data)328PRIDEPhosphoserine
Modified residue332UniProtPhosphoserine
Modified residue (large scale data)332PRIDEPhosphoserine
Modified residue366UniProtPhosphoserine
Modified residue (large scale data)366PRIDEPhosphoserine
Modified residue (large scale data)374PRIDEPhosphoserine

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Organism-specific databases

Interaction

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for coiled coil, compositional bias, region.

TypeIDPosition(s)Description
Coiled coil35-198
Compositional bias225-245Basic and acidic residues
Region225-436Disordered
Compositional bias276-339Polar residues
Compositional bias340-369Basic and acidic residues
Compositional bias386-400Basic and acidic residues
Compositional bias401-421Acidic residues

Sequence similarities

Belongs to the GOLM family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoforms

Align isoforms (4)
  • Sequence status
    Complete

This entry describes 4 isoforms produced by Alternative splicing.

Q6P4E1-4

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    436
  • Mass (Da)
    49,498
  • Last updated
    2019-06-05 v2
  • Checksum
    E11DABFDD27CF70A
MVGFGANRRAGRLPSLVLVVLLVVIVVLAFNYWSISSRHVLLQEEVAELQGQVQRTEVARGRLEKRNSDLLLLVDTHKKQIDQKEADYGRLSSRLQAREGLGKRCEDDKVKLQNNISYQMADIHHLKEQLAELRQEFLRQEDQLQDYRKNNTYLVKRLEYESFQCGQQMKELRAQHEENIKKLADQFLEEQKQETQKIQSNDGKELDINNQVVPKNIPKVAENVADKNEEPSSNHIPHGKEQIKRGGDAGMPGIEENDLAKVDDLPPALRKPPISVSQHESHQAISHLPTGQPLSPNMPPDSHINHNGNPGTSKQNPSSPLQRLIPGSNLDSEPRIQTDILKQATKDRVSDFHKLKQSRFFDENESPVDPQHGSKLADYNGDDGNVGEYEADKQAELAYNEEEDGDGGEEDVQDDEERELQMDPADYGKQHFNDVL

Q6P4E1-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 358-414: SRFFDENESPVDPQHGSKLADYNGDDGNVGEYEADKQAELAYNEEEDGDGGEEDVQD → N

Q6P4E1-3

Q6P4E1-5

  • Name
    5
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 1-22: MVGFGANRRAGRLPSLVLVVLL → M

Computationally mapped potential isoform sequences

There are 5 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
H0YMR0H0YMR0_HUMANGOLM2112
H0YN36H0YN36_HUMANGOLM282
H0YM51H0YM51_HUMANGOLM2161
H0YKJ7H0YKJ7_HUMANGOLM224
A0A3B3IRW9A0A3B3IRW9_HUMANGOLM2317

Sequence caution

The sequence AAH63480.1 differs from that shown. Reason: Miscellaneous discrepancy Probable cloning artifact.

Features

Showing features for alternative sequence, compositional bias, sequence conflict.

TypeIDPosition(s)Description
Alternative sequenceVSP_0601781-22in isoform 5
Alternative sequenceVSP_060179163-177in isoform 3
Alternative sequenceVSP_060180178-436in isoform 3
Compositional bias225-245Basic and acidic residues
Compositional bias276-339Polar residues
Compositional bias340-369Basic and acidic residues
Alternative sequenceVSP_060181358-414in isoform 2
Compositional bias386-400Basic and acidic residues
Compositional bias401-421Acidic residues
Sequence conflict429in Ref. 3

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AY358086
EMBL· GenBank· DDBJ
AAQ88453.1
EMBL· GenBank· DDBJ
mRNA
AK298564
EMBL· GenBank· DDBJ
BAG60758.1
EMBL· GenBank· DDBJ
mRNA
AL832333
EMBL· GenBank· DDBJ
-mRNA No translation available.
AC025043
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC090519
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
CH471082
EMBL· GenBank· DDBJ
EAW77258.1
EMBL· GenBank· DDBJ
Genomic DNA
BC012124
EMBL· GenBank· DDBJ
AAH12124.1
EMBL· GenBank· DDBJ
mRNA
BC063480
EMBL· GenBank· DDBJ
AAH63480.1
EMBL· GenBank· DDBJ
mRNA Sequence problems.

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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