Q6P3Z7 · Q6P3Z7_MOUSE
- ProteinTroponin T, cardiac muscle
- GeneTnnt2
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids302 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cardiac myofibril | |
Cellular Component | cardiac Troponin complex | |
Molecular Function | actin binding | |
Molecular Function | tropomyosin binding | |
Molecular Function | troponin C binding | |
Molecular Function | troponin I binding | |
Biological Process | cardiac muscle contraction | |
Biological Process | muscle filament sliding | |
Biological Process | regulation of heart contraction | |
Biological Process | regulation of muscle contraction | |
Biological Process | response to calcium ion | |
Biological Process | ventricular cardiac muscle tissue morphogenesis |
Keywords
- Molecular function
Names & Taxonomy
Protein names
- Recommended nameTroponin T, cardiac muscle
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ6P3Z7
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Proteomic databases
Expression
Gene expression databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for compositional bias, region, coiled coil.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-72 | Acidic residues | ||||
Sequence: MSDAEEVVEEYEEEQEEAVEEEDWSEEEEDEQEEAVEEEEAGGAEPEPEGEAETEEANVEEVGPDEEAKDAE | ||||||
Region | 1-101 | Disordered | ||||
Sequence: MSDAEEVVEEYEEEQEEAVEEEDWSEEEEDEQEEAVEEEEAGGAEPEPEGEAETEEANVEEVGPDEEAKDAEEGPVEDTKPKPSRLFMPNLVPPKIPDGER | ||||||
Compositional bias | 129-195 | Basic and acidic residues | ||||
Sequence: NRKKEEEELISLKDRIEKRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARKKKAL | ||||||
Region | 129-226 | Disordered | ||||
Sequence: NRKKEEEELISLKDRIEKRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARKKKALSNMMHFGGYIQKTERKSGKRQTEREKKKKIL | ||||||
Compositional bias | 207-226 | Basic and acidic residues | ||||
Sequence: KTERKSGKRQTEREKKKKIL | ||||||
Coiled coil | 240-274 | |||||
Sequence: EDQLREKAKELWQSIHNLEAEKFDLQEKFKQQKYE |
Sequence similarities
Belongs to the troponin T family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length302
- Mass (Da)35,927
- Last updated2004-07-05 v1
- Checksum1415C5CE88ADC212
Computationally mapped potential isoform sequences
There are 3 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
P50752 | TNNT2_MOUSE | Tnnt2 | 301 | ||
A0A087WQP1 | A0A087WQP1_MOUSE | Tnnt2 | 114 | ||
A0A087WRX3 | A0A087WRX3_MOUSE | Tnnt2 | 206 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-72 | Acidic residues | ||||
Sequence: MSDAEEVVEEYEEEQEEAVEEEDWSEEEEDEQEEAVEEEEAGGAEPEPEGEAETEEANVEEVGPDEEAKDAE | ||||||
Compositional bias | 129-195 | Basic and acidic residues | ||||
Sequence: NRKKEEEELISLKDRIEKRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARKKKAL | ||||||
Compositional bias | 207-226 | Basic and acidic residues | ||||
Sequence: KTERKSGKRQTEREKKKKIL |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BC063753 EMBL· GenBank· DDBJ | AAH63753.1 EMBL· GenBank· DDBJ | mRNA | ||
AK146945 EMBL· GenBank· DDBJ | BAE27554.1 EMBL· GenBank· DDBJ | mRNA |