Q6P3W2 · DJC24_HUMAN
- ProteinDnaJ homolog subfamily C member 24
- GeneDNAJC24
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids149 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Stimulates the ATPase activity of several Hsp70-type chaperones. This ability is enhanced by iron-binding. The iron-bound form is redox-active and can function as electron carrier. Plays a role in the diphthamide biosynthesis, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2) which can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A (Eta).
Pathway
Protein modification; peptidyl-diphthamide biosynthesis.
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | cytoskeleton | |
Molecular Function | ATPase activator activity | |
Molecular Function | ferrous iron binding | |
Molecular Function | zinc ion binding | |
Biological Process | chaperone-mediated protein folding | |
Biological Process | positive regulation of ATP-dependent activity | |
Biological Process | protein histidyl modification to diphthamide |
Keywords
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDnaJ homolog subfamily C member 24
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ6P3W2
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Disease & Variants
Features
Showing features for natural variant, mutagenesis.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_036397 | 23 | in a breast cancer sample; somatic mutation; dbSNP:rs111299050 | |||
Sequence: N → D | ||||||
Mutagenesis | 139 | Loss of iron-binding. | ||||
Sequence: C → S |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 157 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000082622 | 1-149 | DnaJ homolog subfamily C member 24 | |||
Sequence: MMAVEQMPKKDWYSILGADPSANISDLKQKYQKLILMYHPDKQSTDVPAGTVEECVQKFIEIDQAWKILGNEETKREYDLQRCEDDLRNVGPVDAQVYLEEMSWNEGDHSFYLSCRCGGKYSVSKDEAEEVSLISCDTCSLIIELLHYN |
Proteomic databases
PTM databases
Expression
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 11-82 | J | ||||
Sequence: DWYSILGADPSANISDLKQKYQKLILMYHPDKQSTDVPAGTVEECVQKFIEIDQAWKILGNEETKREYDLQR | ||||||
Domain | 93-148 | DPH-type MB | ||||
Sequence: VDAQVYLEEMSWNEGDHSFYLSCRCGGKYSVSKDEAEEVSLISCDTCSLIIELLHY |
Domain
The DPH-type metal-binding (MB) domain can bind either zinc or iron ions.
Sequence similarities
Belongs to the DPH4 family.
Phylogenomic databases
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
This entry describes 2 isoforms produced by Alternative splicing.
Q6P3W2-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length149
- Mass (Da)17,139
- Last updated2018-09-12 v2
- Checksum84A4BC5F6D2A3F4C
Q6P3W2-2
- Name2
- Differences from canonical
- 84-149: EDDLRNVGPVDAQVYLEEMSWNEGDHSFYLSCRCGGKYSVSKDEAEEVSLISCDTCSLIIELLHYN → GS
Computationally mapped potential isoform sequences
There are 4 potential isoforms mapped to this entry
Sequence caution
Features
Showing features for alternative sequence.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_056274 | 84-149 | in isoform 2 | |||
Sequence: EDDLRNVGPVDAQVYLEEMSWNEGDHSFYLSCRCGGKYSVSKDEAEEVSLISCDTCSLIIELLHYN → GS |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AK289665 EMBL· GenBank· DDBJ | BAF82354.1 EMBL· GenBank· DDBJ | mRNA | Different initiation | |
AC108456 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AL137804 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CH471064 EMBL· GenBank· DDBJ | EAW68245.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC036571 EMBL· GenBank· DDBJ | AAH36571.1 EMBL· GenBank· DDBJ | mRNA | Different initiation | |
BC063804 EMBL· GenBank· DDBJ | AAH63804.1 EMBL· GenBank· DDBJ | mRNA | Different initiation |