Q6P3W2 · DJC24_HUMAN

  • Protein
    DnaJ homolog subfamily C member 24
  • Gene
    DNAJC24
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Stimulates the ATPase activity of several Hsp70-type chaperones. This ability is enhanced by iron-binding. The iron-bound form is redox-active and can function as electron carrier. Plays a role in the diphthamide biosynthesis, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2) which can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A (Eta).

Caution

It is uncertain whether Met-1 or Met-2 is the initiator.

Pathway

Protein modification; peptidyl-diphthamide biosynthesis.

Features

Showing features for binding site.

114920406080100120140
TypeIDPosition(s)Description
Binding site115Zn2+ (UniProtKB | ChEBI)
Binding site117Zn2+ (UniProtKB | ChEBI)
Binding site136Zn2+ (UniProtKB | ChEBI)
Binding site139Zn2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentcytoskeleton
Molecular FunctionATPase activator activity
Molecular Functionferrous iron binding
Molecular Functionzinc ion binding
Biological Processchaperone-mediated protein folding
Biological Processpositive regulation of ATP-dependent activity
Biological Processprotein histidyl modification to diphthamide

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    DnaJ homolog subfamily C member 24
  • Alternative names
    • CSL-type zinc finger-containing protein 3
    • Diphthamide biosynthesis protein 4

Gene names

    • Name
      DNAJC24
    • Synonyms
      DPH4, ZCSL3

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q6P3W2
  • Secondary accessions
    • A8K0V0
    • B1ALC1
    • I6L9B4

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Disease & Variants

Features

Showing features for natural variant, mutagenesis.

TypeIDPosition(s)Description
Natural variantVAR_03639723in a breast cancer sample; somatic mutation; dbSNP:rs111299050
Mutagenesis139Loss of iron-binding.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 157 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000826221-149DnaJ homolog subfamily C member 24

Proteomic databases

PTM databases

Expression

Gene expression databases

Organism-specific databases

Interaction

Subunit

Monomer and homooligomer. Iron binding promotes oligomerization.

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain11-82J
Domain93-148DPH-type MB

Domain

The DPH-type metal-binding (MB) domain can bind either zinc or iron ions.

Sequence similarities

Belongs to the DPH4 family.

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

Q6P3W2-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    149
  • Mass (Da)
    17,139
  • Last updated
    2018-09-12 v2
  • Checksum
    84A4BC5F6D2A3F4C
MMAVEQMPKKDWYSILGADPSANISDLKQKYQKLILMYHPDKQSTDVPAGTVEECVQKFIEIDQAWKILGNEETKREYDLQRCEDDLRNVGPVDAQVYLEEMSWNEGDHSFYLSCRCGGKYSVSKDEAEEVSLISCDTCSLIIELLHYN

Q6P3W2-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 84-149: EDDLRNVGPVDAQVYLEEMSWNEGDHSFYLSCRCGGKYSVSKDEAEEVSLISCDTCSLIIELLHYN → GS

Computationally mapped potential isoform sequences

There are 4 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
J3KPT8J3KPT8_HUMANDNAJC2429
H0YCV1H0YCV1_HUMANDNAJC2442
E9PRW3E9PRW3_HUMANDNAJC2443
E9PID3E9PID3_HUMANDNAJC2444

Sequence caution

The sequence AAH36571.1 differs from that shown. Reason: Erroneous initiation Truncated N-terminus.
The sequence AAH63804.1 differs from that shown. Reason: Erroneous initiation Truncated N-terminus.
The sequence BAF82354.1 differs from that shown. Reason: Erroneous initiation Truncated N-terminus.

Features

Showing features for alternative sequence.

TypeIDPosition(s)Description
Alternative sequenceVSP_05627484-149in isoform 2

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AK289665
EMBL· GenBank· DDBJ
BAF82354.1
EMBL· GenBank· DDBJ
mRNA Different initiation
AC108456
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AL137804
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
CH471064
EMBL· GenBank· DDBJ
EAW68245.1
EMBL· GenBank· DDBJ
Genomic DNA
BC036571
EMBL· GenBank· DDBJ
AAH36571.1
EMBL· GenBank· DDBJ
mRNA Different initiation
BC063804
EMBL· GenBank· DDBJ
AAH63804.1
EMBL· GenBank· DDBJ
mRNA Different initiation

Genome annotation databases

Similar Proteins

Disclaimer

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