Q6P3K7 · KC1DB_DANRE

Function

function

Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Central component of the circadian clock. May act as a negative regulator of circadian rhythmicity by phosphorylating per1 and per2, which may lead to their degradation. Participates in wnt signaling (By similarity).

Catalytic activity

Activity regulation

Exhibits substrate-dependent heparin activation.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site15-23ATP (UniProtKB | ChEBI)
Binding site38ATP (UniProtKB | ChEBI)
Active site128Proton acceptor

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentnucleus
Cellular Componentspindle microtubule
Molecular FunctionATP binding
Molecular Functionprotein serine kinase activity
Molecular Functionprotein serine/threonine kinase activity
Biological Processendocytosis
Biological Processnon-motile cilium assembly
Biological Processpositive regulation of canonical Wnt signaling pathway
Biological Processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
Biological Processregulation of circadian rhythm
Biological Processsignal transduction
Biological Processspindle assembly
Biological ProcessWnt signaling pathway

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Casein kinase I isoform delta-B
  • EC number
  • Short names
    CKI-delta-B; CKId-B

Gene names

    • Name
      csnk1db

Organism names

  • Taxonomic identifier
  • Strain
    • AB
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio

Accessions

  • Primary accession
    Q6P3K7
  • Secondary accessions
    • Q4V962

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00003540881-409Casein kinase I isoform delta-B

Post-translational modification

Autophosphorylated on serine and threonine residues.

Proteomic databases

Expression

Developmental stage

Ubiquitously expressed in embryos until eight hours after fertilization. Highly expressed in the developing neural plate eight hours after fertilization. Detected in telencephalon, retina, diencephalon, mesencephalon, cerebellum and rhombomeres between 24 and 38 hours after fertilization. Detected in tegmentum, myencephalon and notochord 48 hours after fertilization.

Gene expression databases

Interaction

Subunit

Monomer (By similarity).
Interacts with per1 and per2. Component of the circadian core oscillator (By similarity).

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain, compositional bias, region.

TypeIDPosition(s)Description
Domain9-277Protein kinase
Compositional bias300-320Basic and acidic residues
Region300-409Disordered
Region317-341Autoinhibitory
Compositional bias343-360Polar residues
Compositional bias380-409Polar residues

Sequence similarities

Belongs to the protein kinase superfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    409
  • Mass (Da)
    46,831
  • Last updated
    2004-07-05 v1
  • Checksum
    01E418DA8984A787
MELRVGNRYRLGRKIGSGSFGDIYLGTDISVGEEVAIKLECVKTKHPQLHIESKIYKMMQGGVGIPTIKWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFATYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLKFGANRTAEEADRERRERDERMRHSRNPAARGIPAASGRPRPTQDGAPPTPLTPTSHTANTSSPRPVTGMERERKVSMRLHRGAPVNVSSSDLTGRQDTSRMSTSQNSIPFDHHGK

Features

Showing features for sequence conflict, compositional bias.

TypeIDPosition(s)Description
Sequence conflict31in Ref. 2; AAH97045
Sequence conflict96in Ref. 2; AAH97045
Sequence conflict207in Ref. 2; AAH97045
Compositional bias300-320Basic and acidic residues
Compositional bias343-360Polar residues
Compositional bias380-409Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
EU127825
EMBL· GenBank· DDBJ
ABV29337.1
EMBL· GenBank· DDBJ
mRNA
BC063953
EMBL· GenBank· DDBJ
AAH63953.1
EMBL· GenBank· DDBJ
mRNA
BC097045
EMBL· GenBank· DDBJ
AAH97045.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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