Q6P3K7 · KC1DB_DANRE
- ProteinCasein kinase I isoform delta-B
- Genecsnk1db
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids409 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score5/5
Function
function
Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Central component of the circadian clock. May act as a negative regulator of circadian rhythmicity by phosphorylating per1 and per2, which may lead to their degradation. Participates in wnt signaling (By similarity).
Catalytic activity
- ATP + L-seryl-[protein] = ADP + H+ + O-phospho-L-seryl-[protein]
Activity regulation
Exhibits substrate-dependent heparin activation.
Features
Showing features for binding site, active site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | nucleus | |
Cellular Component | spindle microtubule | |
Molecular Function | ATP binding | |
Molecular Function | protein serine kinase activity | |
Molecular Function | protein serine/threonine kinase activity | |
Biological Process | endocytosis | |
Biological Process | non-motile cilium assembly | |
Biological Process | positive regulation of canonical Wnt signaling pathway | |
Biological Process | positive regulation of proteasomal ubiquitin-dependent protein catabolic process | |
Biological Process | regulation of circadian rhythm | |
Biological Process | signal transduction | |
Biological Process | spindle assembly | |
Biological Process | Wnt signaling pathway |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCasein kinase I isoform delta-B
- EC number
- Short namesCKI-delta-B; CKId-B
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio
Accessions
- Primary accessionQ6P3K7
- Secondary accessions
Proteomes
Organism-specific databases
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000354088 | 1-409 | Casein kinase I isoform delta-B | |||
Sequence: MELRVGNRYRLGRKIGSGSFGDIYLGTDISVGEEVAIKLECVKTKHPQLHIESKIYKMMQGGVGIPTIKWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFATYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLKFGANRTAEEADRERRERDERMRHSRNPAARGIPAASGRPRPTQDGAPPTPLTPTSHTANTSSPRPVTGMERERKVSMRLHRGAPVNVSSSDLTGRQDTSRMSTSQNSIPFDHHGK |
Post-translational modification
Autophosphorylated on serine and threonine residues.
Proteomic databases
Expression
Developmental stage
Ubiquitously expressed in embryos until eight hours after fertilization. Highly expressed in the developing neural plate eight hours after fertilization. Detected in telencephalon, retina, diencephalon, mesencephalon, cerebellum and rhombomeres between 24 and 38 hours after fertilization. Detected in tegmentum, myencephalon and notochord 48 hours after fertilization.
Gene expression databases
Interaction
Subunit
Monomer (By similarity).
Interacts with per1 and per2. Component of the circadian core oscillator (By similarity).
Interacts with per1 and per2. Component of the circadian core oscillator (By similarity).
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, compositional bias, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 9-277 | Protein kinase | ||||
Sequence: YRLGRKIGSGSFGDIYLGTDISVGEEVAIKLECVKTKHPQLHIESKIYKMMQGGVGIPTIKWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFATYLNFCRSLRFDDKPDYSYLRQLFRNLF | ||||||
Compositional bias | 300-320 | Basic and acidic residues | ||||
Sequence: TAEEADRERRERDERMRHSRN | ||||||
Region | 300-409 | Disordered | ||||
Sequence: TAEEADRERRERDERMRHSRNPAARGIPAASGRPRPTQDGAPPTPLTPTSHTANTSSPRPVTGMERERKVSMRLHRGAPVNVSSSDLTGRQDTSRMSTSQNSIPFDHHGK | ||||||
Region | 317-341 | Autoinhibitory | ||||
Sequence: HSRNPAARGIPAASGRPRPTQDGAP | ||||||
Compositional bias | 343-360 | Polar residues | ||||
Sequence: TPLTPTSHTANTSSPRPV | ||||||
Compositional bias | 380-409 | Polar residues | ||||
Sequence: NVSSSDLTGRQDTSRMSTSQNSIPFDHHGK |
Sequence similarities
Belongs to the protein kinase superfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length409
- Mass (Da)46,831
- Last updated2004-07-05 v1
- Checksum01E418DA8984A787
Features
Showing features for sequence conflict, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 31 | in Ref. 2; AAH97045 | ||||
Sequence: V → I | ||||||
Sequence conflict | 96 | in Ref. 2; AAH97045 | ||||
Sequence: C → R | ||||||
Sequence conflict | 207 | in Ref. 2; AAH97045 | ||||
Sequence: N → D | ||||||
Compositional bias | 300-320 | Basic and acidic residues | ||||
Sequence: TAEEADRERRERDERMRHSRN | ||||||
Compositional bias | 343-360 | Polar residues | ||||
Sequence: TPLTPTSHTANTSSPRPV | ||||||
Compositional bias | 380-409 | Polar residues | ||||
Sequence: NVSSSDLTGRQDTSRMSTSQNSIPFDHHGK |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
EU127825 EMBL· GenBank· DDBJ | ABV29337.1 EMBL· GenBank· DDBJ | mRNA | ||
BC063953 EMBL· GenBank· DDBJ | AAH63953.1 EMBL· GenBank· DDBJ | mRNA | ||
BC097045 EMBL· GenBank· DDBJ | AAH97045.1 EMBL· GenBank· DDBJ | mRNA |