Q6P1Q9 · MET2B_HUMAN
- ProteintRNA N(3)-methylcytidine methyltransferase METTL2B
- GeneMETTL2B
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids378 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
S-adenosyl-L-methionine-dependent methyltransferase that mediates N3-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA(Thr)(UGU) and tRNA(Arg)(CCU).
Catalytic activity
- cytidine32 in tRNA(Thr) + S-adenosyl-L-methionine = H+ + N3-methylcytidine32 in tRNA(Thr) + S-adenosyl-L-homocysteineThis reaction proceeds in the forward direction.
- cytidine32 in tRNA(Arg)(CCU) + S-adenosyl-L-methionine = H+ + N3-methylcytidine32 in tRNA(Arg)(CCU) + S-adenosyl-L-homocysteineThis reaction proceeds in the forward direction.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 78 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: W | ||||||
Binding site | 82 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: Y | ||||||
Binding site | 188 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Binding site | 213 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 239 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 240 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: L | ||||||
Binding site | 260 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: I |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | tRNA (cytidine) methyltransferase activity | |
Molecular Function | tRNA (cytidine-3-)-methyltransferase activity | |
Biological Process | tRNA metabolic process | |
Biological Process | tRNA methylation |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nametRNA N(3)-methylcytidine methyltransferase METTL2B
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ6P1Q9
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Disease & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_059465 | 68 | in dbSNP:rs2288557 | |||
Sequence: V → I | ||||||
Natural variant | VAR_042547 | 124 | in dbSNP:rs2896399 | |||
Sequence: C → R | ||||||
Natural variant | VAR_042548 | 129 | in dbSNP:rs2023329 | |||
Sequence: N → H | ||||||
Natural variant | VAR_042549 | 169 | in dbSNP:rs1065267 | |||
Sequence: E → K | ||||||
Natural variant | VAR_042550 | 266 | in dbSNP:rs2562741 | |||
Sequence: V → I |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 441 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for initiator methionine, modified residue, chain, modified residue (large scale data).
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Initiator methionine | 1 | UniProt | Removed | ||||
Sequence: M | |||||||
Modified residue | 2 | UniProt | N-acetylalanine | ||||
Sequence: A | |||||||
Chain | PRO_0000328847 | 2-378 | UniProt | tRNA N3-methylcytidine methyltransferase METTL2B | |||
Sequence: AGSYPEGAPAILADKRQQFGSRFLSDPARVFHHNAWDNVEWSEEQAAAAERKVQENSIQRVCQEKQVDYEINAHKYWNDFYKIHENGFFKDRHWLFTEFPELAPSQNQNHLKDWFLENKSEVCECRNNEDGPGLIMEEQHKCSSKSLEHKTQTPPVEENVTQKISDLEICADEFPGSSATYRILEVGCGVGNTVFPILQTNNDPGLFVYCCDFSSTAIELVQTNSEYDPSRCFAFVHDLCDEEKSYPVPKGSLDIIILIFVLSAVVPDKMQKAINRLSRLLKPGGMVLLRDYGRYDMAQLRFKKGQCLSGNFYVRGDGTRVYFFTQEELDTLFTTAGLEKVQNLVDRRLQVNRGKQLTMYRVWIQCKYCKPLLSSTS | |||||||
Modified residue | 4 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 4 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue | 154 | UniProt | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue (large scale data) | 154 | PRIDE | Phosphothreonine | ||||
Sequence: T |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Structure
Sequence & Isoform
- Sequence statusComplete
This entry describes 2 isoforms produced by Alternative splicing.
Q6P1Q9-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length378
- Mass (Da)43,426
- Last updated2011-01-11 v3
- ChecksumA9719EF1074BA011
Q6P1Q9-2
- Name2
- Differences from canonical
- 1-67: MAGSYPEGAPAILADKRQQFGSRFLSDPARVFHHNAWDNVEWSEEQAAAAERKVQENSIQRVCQEKQ → MP
Computationally mapped potential isoform sequences
There are 3 potential isoforms mapped to this entry
Features
Showing features for alternative sequence.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_032816 | 1-67 | in isoform 2 | |||
Sequence: MAGSYPEGAPAILADKRQQFGSRFLSDPARVFHHNAWDNVEWSEEQAAAAERKVQENSIQRVCQEKQ → MP |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AK002212 EMBL· GenBank· DDBJ | BAA92136.1 EMBL· GenBank· DDBJ | mRNA | ||
AK302775 EMBL· GenBank· DDBJ | BAG63980.1 EMBL· GenBank· DDBJ | mRNA | ||
AC010655 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC090114 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BC064929 EMBL· GenBank· DDBJ | AAH64929.1 EMBL· GenBank· DDBJ | mRNA | ||
BC107586 EMBL· GenBank· DDBJ | AAI07587.1 EMBL· GenBank· DDBJ | mRNA | ||
BC121115 EMBL· GenBank· DDBJ | AAI21116.1 EMBL· GenBank· DDBJ | mRNA | ||
BC121116 EMBL· GenBank· DDBJ | AAI21117.1 EMBL· GenBank· DDBJ | mRNA |