Q6P1E8 · EFCB6_MOUSE
- ProteinEF-hand calcium-binding domain-containing protein 6
- GeneEfcab6
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids1516 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Negatively regulates the androgen receptor by recruiting histone deacetylase complex, and protein DJ-1 antagonizes this inhibition by abrogation of this complex (By similarity).
Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating (PubMed:37295417, PubMed:37865089, PubMed:37989994).
Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating (PubMed:37295417, PubMed:37865089, PubMed:37989994).
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 109 | Ca2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 111 | Ca2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 113 | Ca2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 115 | Ca2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: M | ||||||
Binding site | 120 | Ca2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 210 | Ca2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 212 | Ca2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 214 | Ca2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 221 | Ca2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 776 | Ca2+ 3 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 778 | Ca2+ 3 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 780 | Ca2+ 3 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 787 | Ca2+ 3 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 1462 | Ca2+ 4 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 1464 | Ca2+ 4 (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 1466 | Ca2+ 4 (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 1473 | Ca2+ 4 (UniProtKB | ChEBI) | ||||
Sequence: D |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | axonemal A tubule inner sheath | |
Cellular Component | nucleoplasm | |
Cellular Component | sperm flagellum | |
Molecular Function | calcium ion binding | |
Biological Process | flagellated sperm motility |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameEF-hand calcium-binding domain-containing protein 6
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ6P1E8
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000246026 | 1-1516 | EF-hand calcium-binding domain-containing protein 6 | |||
Sequence: MKRNGTRLNFAKANSTKSGSTRARDLMNKMSIIPEWHSLYSNTRKLPCSRPHSSPCKMQRTIFQDLCRPSSSTTAIANPVLSYLDIERILAQKISSRRDDIKKVFQILDRNHNQMVTKGDLKRVITAFLIPLTKDQFQDLLAQIPISSLGNVPYLEFLSRFGGGIDININGIKRVNENEVDNRRTVKEVQLTEKIFRNMRSIRKVFQVMDVNNTGLVQPQELRRVLETFCLRMQDGDYEKFLEQYNIDKTTAVDYNAFLKNLSVKNDASFKYLLSNAAELSRETQQGKNGKRLLDTGSSEDVWKNYSLDDLEKTFCQEFSKSYEKIEKALSAGDPSKGGYISLNYLKVVLDTFIYRLPRRIFIQLIRRFGLKTSTKINWKQFLTAIYERQKLEVSKTLPLKKRSSTEARNRSRKENIIKKLFKYSEDRYTALKKTLLIISSTPSGHITWEELRHILNCMVAKLNDSEFSELKQTFDPEGTGAVRVNSLLDVLDDSTKVRKMSPSTDTKTPLPVAWDSVEELVLDSITRNLQAFYSMLQSYDLRDTGTIGKNNFRKVMRVFCPYLSNEHLVRFSSKFQEAGSGRILYKKFLLSIGVGIPPPTPPLSSPKVQLSDQFQIEEPGQQDERTQPSGEKTSEINNMTKEEVIDGLKHRIQQKDPVFRKQFLSISKEPDVKINQEEFRKVLERSGMPMNDCQYAMLASKLGFKNEEGMSYQDFTMGFEDCMLSGLETVPLQSRTASRTNMDEHFISAEECLRIFPKKLKESFRDVYSAFFRIDLDRDGIISMHDFHRLLQYLQLNMVDLEFERFLSLLGLRLSVTLNFREFQNLCEKRPWKSDEAPQRLIRCKQKVADSELACEQAHQYLIMKAKTRWADLSKNFIETDNEGNGILRRRDIKNSLYGFDIPLTPREFEKLWQNYDTEGRGYITYQEFLHRLGIRYSPKVHRPYKEDYFNFLGHFTKPKQVQEEIQELQQISEREKLMNHYEEISKAFNAMEKSKPVALCRVQKVLQECGCPLKEEELISLLKSLDVSVHNNHIDPVEFLRALEISWASKARPKEKEESSPPPISFSKVTPDEVIKTMQEVVESSQPALVEAFSALDKEDTGFVKAMEFGDVLRSVCQKLTDNQYHYFLRRLRLHLTPNIHWKYFLENFSTFQDETADDWAENMPKAPPPMSPKETAHRDIVARVQKAVASHYHTIVQEFENFDTLKSNTVSRDEFRSICTRHIQILTDEQFDRLWSELPVNAKGRLKYQDFLSKLSIERVPSPPMAAGDSGESTMAQRGSSAPEFSQGTRSNLYSPPRDSRVGLKSRSHPCTPVGTPPLQNCEPIESRLRKQIQGCWRELLRECKEKDTDKQGTISAAEFLALVEKFKLDISREESQQLIVKYDLKNNGKFAYCDFIQSCVLLLKAKETSLMRRMRIQNADKMKEAGMETPSFYSALLRIQPKIVHCWRPMRRSFKTYDKNGTGLLSVADFRKVLRQYSINLSEEEFFHVLEYYDKSLSSKISYNDFLRAFLQ | ||||||
Modified residue | 906 | Phosphothreonine | ||||
Sequence: T | ||||||
Modified residue | 1265 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 1311 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 1315 | Phosphothreonine | ||||
Sequence: T | ||||||
Modified residue | 1319 | Phosphothreonine | ||||
Sequence: T |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Gene expression databases
Interaction
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-23 | Disordered | ||||
Sequence: MKRNGTRLNFAKANSTKSGSTRA | ||||||
Compositional bias | 8-23 | Polar residues | ||||
Sequence: LNFAKANSTKSGSTRA | ||||||
Domain | 96-131 | EF-hand 1 | ||||
Sequence: SRRDDIKKVFQILDRNHNQMVTKGDLKRVITAFLIP | ||||||
Domain | 197-232 | EF-hand 2 | ||||
Sequence: RNMRSIRKVFQVMDVNNTGLVQPQELRRVLETFCLR | ||||||
Domain | 321-356 | EF-hand 3 | ||||
Sequence: KSYEKIEKALSAGDPSKGGYISLNYLKVVLDTFIYR | ||||||
Domain | 444-462 | EF-hand 4 | ||||
Sequence: SGHITWEELRHILNCMVAK | ||||||
Domain | 528-563 | EF-hand 5 | ||||
Sequence: RNLQAFYSMLQSYDLRDTGTIGKNNFRKVMRVFCPY | ||||||
Region | 618-638 | Disordered | ||||
Sequence: EEPGQQDERTQPSGEKTSEIN | ||||||
Domain | 674-690 | EF-hand 6 | ||||
Sequence: KINQEEFRKVLERSGMP | ||||||
Domain | 763-798 | EF-hand 7 | ||||
Sequence: ESFRDVYSAFFRIDLDRDGIISMHDFHRLLQYLQLN | ||||||
Domain | 905-940 | EF-hand 8 | ||||
Sequence: LTPREFEKLWQNYDTEGRGYITYQEFLHRLGIRYSP | ||||||
Domain | 1086-1121 | EF-hand 9 | ||||
Sequence: SSQPALVEAFSALDKEDTGFVKAMEFGDVLRSVCQK | ||||||
Domain | 1193-1228 | EF-hand 10 | ||||
Sequence: SHYHTIVQEFENFDTLKSNTVSRDEFRSICTRHIQI | ||||||
Domain | 1229-1264 | EF-hand 11 | ||||
Sequence: LTDEQFDRLWSELPVNAKGRLKYQDFLSKLSIERVP | ||||||
Region | 1263-1318 | Disordered | ||||
Sequence: VPSPPMAAGDSGESTMAQRGSSAPEFSQGTRSNLYSPPRDSRVGLKSRSHPCTPVG | ||||||
Compositional bias | 1276-1299 | Polar residues | ||||
Sequence: STMAQRGSSAPEFSQGTRSNLYSP | ||||||
Region | 1318-1516 | Interaction with PARK7 | ||||
Sequence: GTPPLQNCEPIESRLRKQIQGCWRELLRECKEKDTDKQGTISAAEFLALVEKFKLDISREESQQLIVKYDLKNNGKFAYCDFIQSCVLLLKAKETSLMRRMRIQNADKMKEAGMETPSFYSALLRIQPKIVHCWRPMRRSFKTYDKNGTGLLSVADFRKVLRQYSINLSEEEFFHVLEYYDKSLSSKISYNDFLRAFLQ | ||||||
Domain | 1348-1373 | EF-hand 12 | ||||
Sequence: KEKDTDKQGTISAAEFLALVEKFKLD | ||||||
Domain | 1374-1409 | EF-hand 13 | ||||
Sequence: ISREESQQLIVKYDLKNNGKFAYCDFIQSCVLLLKA | ||||||
Region | 1422-1516 | Interaction with AR | ||||
Sequence: NADKMKEAGMETPSFYSALLRIQPKIVHCWRPMRRSFKTYDKNGTGLLSVADFRKVLRQYSINLSEEEFFHVLEYYDKSLSSKISYNDFLRAFLQ | ||||||
Domain | 1454-1484 | EF-hand 14 | ||||
Sequence: MRRSFKTYDKNGTGLLSVADFRKVLRQYSIN | ||||||
Domain | 1485-1516 | EF-hand 15 | ||||
Sequence: LSEEEFFHVLEYYDKSLSSKISYNDFLRAFLQ |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoforms
- Sequence statusComplete
This entry describes 3 isoforms produced by Alternative splicing.
Q6P1E8-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length1,516
- Mass (Da)175,771
- Last updated2007-11-13 v2
- Checksum786C634E6CFA5CFD
Q6P1E8-3
- Name2
- Differences from canonical
- 1-688: Missing
Q6P1E8-4
- Name3
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
F6RST1 | F6RST1_MOUSE | Efcab6 | 70 |
Sequence caution
Features
Showing features for alternative sequence, compositional bias, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_019814 | 1-688 | in isoform 2 | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_029427 | 1-838 | in isoform 3 | |||
Sequence: Missing | ||||||
Compositional bias | 8-23 | Polar residues | ||||
Sequence: LNFAKANSTKSGSTRA | ||||||
Sequence conflict | 632 | in Ref. 4; AAH65111 | ||||
Sequence: E → K | ||||||
Alternative sequence | VSP_029428 | 839-844 | in isoform 3 | |||
Sequence: PQRLIR → MSKKHG | ||||||
Sequence conflict | 1101 | in Ref. 2; BAD90458 | ||||
Sequence: E → V | ||||||
Sequence conflict | 1181 | in Ref. 2; BAD90458 | ||||
Sequence: R → K | ||||||
Compositional bias | 1276-1299 | Polar residues | ||||
Sequence: STMAQRGSSAPEFSQGTRSNLYSP | ||||||
Sequence conflict | 1391 | in Ref. 4; AAH56955 | ||||
Sequence: Missing |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AK019850 EMBL· GenBank· DDBJ | BAB31880.1 EMBL· GenBank· DDBJ | mRNA | ||
AK220412 EMBL· GenBank· DDBJ | BAD90458.1 EMBL· GenBank· DDBJ | mRNA | ||
AL513354 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AL603867 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BC056955 EMBL· GenBank· DDBJ | AAH56955.1 EMBL· GenBank· DDBJ | mRNA | Different initiation | |
BC065111 EMBL· GenBank· DDBJ | AAH65111.1 EMBL· GenBank· DDBJ | mRNA | Different initiation |