Q6P104 · QKIB_DANRE

Function

function

RNA reader protein, which recognizes and binds specific RNAs, thereby regulating RNA metabolic processes, such as pre-mRNA splicing, circular RNA (circRNA) formation, mRNA export, mRNA stability and/or translation (PubMed:28867488).
Involved in various cellular processes, such as mRNA storage into stress granules, apoptosis, interferon response, glial cell fate and development (By similarity).
Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence (By similarity).
Acts as a mRNA modification reader that specifically recognizes and binds mRNA transcripts modified by internal N7-methylguanine (m7G) (By similarity).
Promotes the formation of circular RNAs (circRNAs): acts by binding to sites flanking circRNA-forming exons (By similarity).
CircRNAs are produced by back-splicing circularization of pre-mRNAs (By similarity).
Required to protect and promote stability of mRNAs which promotes oligodendrocyte differentiation (By similarity).
Acts as an important regulator of muscle development: required during early skeletal myofibril formation by regulating the accumulation of the muscle-specific tropomyosin-3 (tpm3) transcripts (PubMed:28867488).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentnucleus
Molecular FunctionmRNA 3'-UTR binding
Molecular FunctionmRNA binding
Molecular FunctionSH3 domain binding
Biological ProcessmRNA transport
Biological Processnegative regulation of macrophage differentiation
Biological Processregulation of astrocyte differentiation
Biological Processregulation of mRNA splicing, via spliceosome
Biological Processregulation of translation
Biological Processskeletal myofibril assembly
Biological Processspliceosome-depend formation of circular RNA

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Protein quaking-B
  • Alternative names
    • Quaking-related protein

Gene names

    • Name
      qki2
    • Synonyms
      qkib, qkic
      , qkr
    • ORF names
      zgc:65890, zgc:77340

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio

Accessions

  • Primary accession
    Q6P104
  • Secondary accessions
    • Q6P7D9

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002393791-319Protein quaking-B

Proteomic databases

Expression

Gene expression databases

Interaction

Subunit

Homodimer; does not require RNA to homodimerize.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain, motif.

TypeIDPosition(s)Description
Domain87-153KH
Motif276-279SH3-binding

Sequence similarities

Belongs to the quaking family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

Q6P104-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    319
  • Mass (Da)
    35,256
  • Last updated
    2004-07-05 v1
  • Checksum
    B072D5CB218F3FF8
MVGEMETKEKPKPTPDYLMQLMNDKKLMSSLPNFCGIFNHLERLLDEEIGRVRKDMYNDTLNGSTDKRTSELPDAVGPIAQLQEKLYVPVKEYPDFNFVGRILGPRGLTAKQLEAETGCKIMVRGKGSMRDKKKEEQNRGKPNWEHLNEDLHVLITVEDSQNRAEIKLKRAVEEVKKLLVPAAEGEDSLKKMQLMELAILNGTYRDANIKSPALAFSLAATAQAPRIMTGPTPVMPNAALRTPAPTAPTLMPLIRQIQTSALMPTGTPHPTATLLPQTPESGIIYAPYDYPYALAPATSILEYPIDSSGVLGMAFPTKG

Q6P104-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A8M9Q889A0A8M9Q889_DANREqki2341
A0A8M9QE52A0A8M9QE52_DANREqki2340

Features

Showing features for alternative sequence.

TypeIDPosition(s)Description
Alternative sequenceVSP_019205213in isoform 2

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB086654
EMBL· GenBank· DDBJ
BAD23948.1
EMBL· GenBank· DDBJ
mRNA
BC061709
EMBL· GenBank· DDBJ
AAH61709.1
EMBL· GenBank· DDBJ
mRNA
BC065344
EMBL· GenBank· DDBJ
AAH65344.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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