Q6P069 · SORCN_MOUSE
- ProteinSorcin
- GeneSri
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids198 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Calcium-binding protein that modulates excitation-contraction coupling in the heart. Contributes to calcium homeostasis in the heart sarcoplasmic reticulum. Modulates the activity of RYR2 calcium channels.
Miscellaneous
This protein has been shown to bind calcium with high affinity.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 83 | Ca2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 85 | Ca2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 87 | Ca2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: S | ||||||
Binding site | 89 | Ca2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 94 | Ca2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 113 | Ca2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 115 | Ca2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 117 | Ca2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: S | ||||||
Binding site | 119 | Ca2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 124 | Ca2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: E |
GO annotations
Keywords
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameSorcin
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ6P069
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Sarcoplasmic reticulum membrane ; Peripheral membrane protein
Note: Relocates to the sarcoplasmic reticulum membrane in response to elevated calcium levels.
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000073726 | 1-198 | Sorcin | |||
Sequence: MAYPGHPGAGGGYYPGGYGGAPGGPAFPGQTQDPLYGYFAAVAGQDGQIDADELQRCLTQSGIAGGYKPFNLETCRLMVSMLDRDMSGTMGFNEFKELWAVLNGWRQHFISFDSDRSGTVDPQELQKALTTMGFRLSPQTVNSVAKRYSTSGKITFDDYIACCVKLRALTDSFRRRDSGQQGVVNFSYDDFIQCVMTV | ||||||
Modified residue | 178 | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
2D gel databases
PTM databases
Expression
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 45-64 | EF-hand 1 | ||||
Sequence: QDGQIDADELQRCLTQSGIA | ||||||
Domain | 70-98 | EF-hand 2 | ||||
Sequence: FNLETCRLMVSMLDRDMSGTMGFNEFKEL | ||||||
Domain | 100-135 | EF-hand 3 | ||||
Sequence: AVLNGWRQHFISFDSDRSGTVDPQELQKALTTMGFR | ||||||
Domain | 151-169 | EF-hand 4 | ||||
Sequence: SGKITFDDYIACCVKLRAL |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
This entry describes 2 isoforms produced by Alternative splicing.
Q6P069-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length198
- Mass (Da)21,627
- Last updated2004-07-05 v1
- Checksum254588544495E1BF
Q6P069-2
- Name2
- Differences from canonical
- 1-17: MAYPGHPGAGGGYYPGG → MQ
Features
Showing features for alternative sequence, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_013448 | 1-17 | in isoform 2 | |||
Sequence: MAYPGHPGAGGGYYPGG → MQ | ||||||
Sequence conflict | 25 | in Ref. 1; BAB25891 | ||||
Sequence: P → A |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AK008404 EMBL· GenBank· DDBJ | BAB25652.1 EMBL· GenBank· DDBJ | mRNA | ||
AK008783 EMBL· GenBank· DDBJ | BAB25891.1 EMBL· GenBank· DDBJ | mRNA | ||
AK008970 EMBL· GenBank· DDBJ | BAB25997.1 EMBL· GenBank· DDBJ | mRNA | ||
AK134747 EMBL· GenBank· DDBJ | BAE22266.1 EMBL· GenBank· DDBJ | mRNA | ||
AK146071 EMBL· GenBank· DDBJ | BAE26876.1 EMBL· GenBank· DDBJ | mRNA | ||
AK146911 EMBL· GenBank· DDBJ | BAE27523.1 EMBL· GenBank· DDBJ | mRNA | ||
AK168572 EMBL· GenBank· DDBJ | BAE40442.1 EMBL· GenBank· DDBJ | mRNA | ||
AK168792 EMBL· GenBank· DDBJ | BAE40625.1 EMBL· GenBank· DDBJ | mRNA | ||
AK168900 EMBL· GenBank· DDBJ | BAE40716.1 EMBL· GenBank· DDBJ | mRNA | ||
BC065790 EMBL· GenBank· DDBJ | AAH65790.1 EMBL· GenBank· DDBJ | mRNA |