Q6NZ18 · KHDC4_DANRE

Function

function

RNA-binding protein involved in pre-mRNA splicing. Interacts with the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome. Involved in regulating splice site selection. Binds preferentially RNA with A/C rich sequences and poly-C stretches.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentnucleus
Molecular FunctionRNA binding
Biological ProcessmRNA splice site recognition

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    KH homology domain-containing protein 4
  • Alternative names
    • Brings lots of money 7
    • Pre-mRNA splicing factor protein khdc4

Gene names

    • Name
      khdc4
    • Synonyms
      blom7
      , Kiaa0907

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio

Accessions

  • Primary accession
    Q6NZ18
  • Secondary accessions
    • Q7ZVX3

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002966721-570KH homology domain-containing protein 4

Keywords

Proteomic databases

Interaction

Subunit

Interacts with PRPF19.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, domain, compositional bias.

TypeIDPosition(s)Description
Region1-29Disordered
Domain77-157KH 1
Domain210-292KH 2
Compositional bias391-405Pro residues
Region391-410Disordered
Region427-497Required for nuclear retention
Region437-500Disordered
Compositional bias440-462Polar residues
Region512-570Disordered
Compositional bias540-554Pro residues
Compositional bias555-570Polar residues

Domain

The C-terminal part is necessary for the interaction with the PRP19C/Prp19 complex/NTC/Nineteen complex.
The KH domains mediate RNA-binding.

Sequence similarities

Belongs to the KHDC4 family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    570
  • Mass (Da)
    60,376
  • Last updated
    2004-07-05 v1
  • Checksum
    D58A37176562AC17
MSFGVPHSGGSRRSKWDQAGPDADAGSAPTGALDAAAAVAAKINAMLVAKGKLKPSQISSAAPVDKAAGAGGNKLKDDLVVAEVEINDVPLTCRNLLTRGQTQDEISRVSGAAVSTRGRFMTVEEKSKALPSDRPLYLHVQGQTRDLVDKAVNRIKEIITNGVVKAATNSTYSGATVTVYQQSGPSVPTIPSAPHKPHYPGGMHYVQDKVFVGLDQALQGFNVKERVEGPSCSFLQHIQAETGAKVFLRGKGSGCLEPASGREAFEPMYIYISHPKPEGLASAKTLCENLLQTVHAEYSRYLNQMSSMMPTQGFIHPPVVNGLPPQPPYYSPAGFQPSYPAPVPPPPPPIAPQYPVAPVAPAPVPPPNAQYPITPVPAHVPTQTLLPAAFPPTAPVPPKLTAPPNPPQKRRFTEEVDEMDRGLLGYQHGPIHMTNLGAGMPVGSSETSGPPSAASSVPVRERDSSRQLMPPPCAPALLKPLRPLKADESPSAPSLLEPQVKRMRTGLVAYAGDSSDEEEDHGPSRAAVTAAGNPGAGWNPYRCPPSPPHRPKTQTAPQPTQQNMPFWMAP

Computationally mapped potential isoform sequences

There are 7 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A8M3AJJ6A0A8M3AJJ6_DANREkhdc4572
A0A8M9P7R6A0A8M9P7R6_DANREkhdc4501
A0A8M3B243A0A8M3B243_DANREkhdc4450
F1QQM1F1QQM1_DANREkhdc4570
A0A8M3ATY7A0A8M3ATY7_DANREkhdc4571
A0A8M3AR35A0A8M3AR35_DANREkhdc4570
A0A8M2BH01A0A8M2BH01_DANREkhdc4571

Features

Showing features for compositional bias, sequence conflict.

TypeIDPosition(s)Description
Compositional bias391-405Pro residues
Compositional bias440-462Polar residues
Sequence conflict464in Ref. 1; AAH45375
Compositional bias540-554Pro residues
Compositional bias555-570Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BC045375
EMBL· GenBank· DDBJ
AAH45375.1
EMBL· GenBank· DDBJ
mRNA
BC066381
EMBL· GenBank· DDBJ
AAH66381.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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