Q6NZ18 · KHDC4_DANRE
- ProteinKH homology domain-containing protein 4
- Genekhdc4
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids570 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
RNA-binding protein involved in pre-mRNA splicing. Interacts with the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome. Involved in regulating splice site selection. Binds preferentially RNA with A/C rich sequences and poly-C stretches.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | nucleus | |
Molecular Function | RNA binding | |
Biological Process | mRNA splice site recognition |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended nameKH homology domain-containing protein 4
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio
Accessions
- Primary accessionQ6NZ18
- Secondary accessions
Proteomes
Organism-specific databases
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000296672 | 1-570 | KH homology domain-containing protein 4 | |||
Sequence: MSFGVPHSGGSRRSKWDQAGPDADAGSAPTGALDAAAAVAAKINAMLVAKGKLKPSQISSAAPVDKAAGAGGNKLKDDLVVAEVEINDVPLTCRNLLTRGQTQDEISRVSGAAVSTRGRFMTVEEKSKALPSDRPLYLHVQGQTRDLVDKAVNRIKEIITNGVVKAATNSTYSGATVTVYQQSGPSVPTIPSAPHKPHYPGGMHYVQDKVFVGLDQALQGFNVKERVEGPSCSFLQHIQAETGAKVFLRGKGSGCLEPASGREAFEPMYIYISHPKPEGLASAKTLCENLLQTVHAEYSRYLNQMSSMMPTQGFIHPPVVNGLPPQPPYYSPAGFQPSYPAPVPPPPPPIAPQYPVAPVAPAPVPPPNAQYPITPVPAHVPTQTLLPAAFPPTAPVPPKLTAPPNPPQKRRFTEEVDEMDRGLLGYQHGPIHMTNLGAGMPVGSSETSGPPSAASSVPVRERDSSRQLMPPPCAPALLKPLRPLKADESPSAPSLLEPQVKRMRTGLVAYAGDSSDEEEDHGPSRAAVTAAGNPGAGWNPYRCPPSPPHRPKTQTAPQPTQQNMPFWMAP |
Keywords
- PTM
Proteomic databases
Interaction
Structure
Family & Domains
Features
Showing features for region, domain, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-29 | Disordered | ||||
Sequence: MSFGVPHSGGSRRSKWDQAGPDADAGSAP | ||||||
Domain | 77-157 | KH 1 | ||||
Sequence: DDLVVAEVEINDVPLTCRNLLTRGQTQDEISRVSGAAVSTRGRFMTVEEKSKALPSDRPLYLHVQGQTRDLVDKAVNRIKE | ||||||
Domain | 210-292 | KH 2 | ||||
Sequence: VFVGLDQALQGFNVKERVEGPSCSFLQHIQAETGAKVFLRGKGSGCLEPASGREAFEPMYIYISHPKPEGLASAKTLCENLLQ | ||||||
Compositional bias | 391-405 | Pro residues | ||||
Sequence: PPTAPVPPKLTAPPN | ||||||
Region | 391-410 | Disordered | ||||
Sequence: PPTAPVPPKLTAPPNPPQKR | ||||||
Region | 427-497 | Required for nuclear retention | ||||
Sequence: QHGPIHMTNLGAGMPVGSSETSGPPSAASSVPVRERDSSRQLMPPPCAPALLKPLRPLKADESPSAPSLLE | ||||||
Region | 437-500 | Disordered | ||||
Sequence: GAGMPVGSSETSGPPSAASSVPVRERDSSRQLMPPPCAPALLKPLRPLKADESPSAPSLLEPQV | ||||||
Compositional bias | 440-462 | Polar residues | ||||
Sequence: MPVGSSETSGPPSAASSVPVRER | ||||||
Region | 512-570 | Disordered | ||||
Sequence: GDSSDEEEDHGPSRAAVTAAGNPGAGWNPYRCPPSPPHRPKTQTAPQPTQQNMPFWMAP | ||||||
Compositional bias | 540-554 | Pro residues | ||||
Sequence: PYRCPPSPPHRPKTQ | ||||||
Compositional bias | 555-570 | Polar residues | ||||
Sequence: TAPQPTQQNMPFWMAP |
Domain
The C-terminal part is necessary for the interaction with the PRP19C/Prp19 complex/NTC/Nineteen complex.
The KH domains mediate RNA-binding.
Sequence similarities
Belongs to the KHDC4 family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length570
- Mass (Da)60,376
- Last updated2004-07-05 v1
- ChecksumD58A37176562AC17
Computationally mapped potential isoform sequences
There are 7 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A8M3AJJ6 | A0A8M3AJJ6_DANRE | khdc4 | 572 | ||
A0A8M9P7R6 | A0A8M9P7R6_DANRE | khdc4 | 501 | ||
A0A8M3B243 | A0A8M3B243_DANRE | khdc4 | 450 | ||
F1QQM1 | F1QQM1_DANRE | khdc4 | 570 | ||
A0A8M3ATY7 | A0A8M3ATY7_DANRE | khdc4 | 571 | ||
A0A8M3AR35 | A0A8M3AR35_DANRE | khdc4 | 570 | ||
A0A8M2BH01 | A0A8M2BH01_DANRE | khdc4 | 571 |
Features
Showing features for compositional bias, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 391-405 | Pro residues | ||||
Sequence: PPTAPVPPKLTAPPN | ||||||
Compositional bias | 440-462 | Polar residues | ||||
Sequence: MPVGSSETSGPPSAASSVPVRER | ||||||
Sequence conflict | 464 | in Ref. 1; AAH45375 | ||||
Sequence: Missing | ||||||
Compositional bias | 540-554 | Pro residues | ||||
Sequence: PYRCPPSPPHRPKTQ | ||||||
Compositional bias | 555-570 | Polar residues | ||||
Sequence: TAPQPTQQNMPFWMAP |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BC045375 EMBL· GenBank· DDBJ | AAH45375.1 EMBL· GenBank· DDBJ | mRNA | ||
BC066381 EMBL· GenBank· DDBJ | AAH66381.1 EMBL· GenBank· DDBJ | mRNA |