Q6NYW6 · CLAP2_DANRE

Function

function

Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentbasal cortex
Cellular Componentcell leading edge
Cellular Componentcentrosome
Cellular Componentcytoplasmic microtubule
Cellular ComponentGolgi apparatus
Cellular Componentkinetochore
Cellular Componentmicrotubule
Cellular Componentmicrotubule organizing center
Cellular Componentmitotic spindle
Cellular Componentruffle membrane
Cellular Componentspindle microtubule
Cellular Componenttrans-Golgi network
Molecular Functionmicrotubule binding
Molecular Functionmicrotubule plus-end binding
Biological Processcell division
Biological Processestablishment of mitotic spindle localization
Biological Processexit from mitosis
Biological ProcessGolgi organization
Biological Processhematopoietic stem cell homeostasis
Biological Processmicrotubule anchoring
Biological Processmicrotubule cytoskeleton organization
Biological Processmicrotubule nucleation
Biological Processmicrotubule organizing center organization
Biological Processmitotic spindle assembly
Biological Processmitotic spindle organization
Biological Processregulation of microtubule polymerization or depolymerization
Biological Processregulation of microtubule-based process

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    CLIP-associating protein 2
  • Alternative names
    • Cytoplasmic linker-associated protein 2

Gene names

    • Name
      clasp2

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio

Accessions

  • Primary accession
    Q6NYW6

Proteomes

Organism-specific databases

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000898481-1288CLIP-associating protein 2

Proteomic databases

Expression

Gene expression databases

Interaction

Subunit

Interacts with microtubules.

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, repeat, compositional bias, motif.

Type
IDPosition(s)Description
Region1-62Disordered
Region62-312TOG 1
Repeat174-209HEAT 1
Repeat210-246HEAT 2
Repeat251-288HEAT 3
Compositional bias314-336Polar residues
Region314-571Disordered
Compositional bias351-365Polar residues
Compositional bias392-481Polar residues
Motif490-493SXIP motif 1
Compositional bias496-520Polar residues
Motif527-530SXIP motif 2
Compositional bias549-571Polar residues
Region614-634Disordered
Region638-889TOG 2
Repeat718-755HEAT 4
Repeat780-817HEAT 5
Region891-936Disordered
Region960-1047Disordered
Compositional bias966-987Basic and acidic residues
Compositional bias988-1031Polar residues
Repeat1047-1086HEAT 6
Repeat1091-1128HEAT 7
Repeat1167-1204HEAT 8
Repeat1209-1246HEAT 9

Domain

The two SXIP sequence motifs are important for targeting to the growing microtubule plus ends.
Two TOG regions display structural characteristics similar to HEAT repeat domains and mediate interaction with microtubules.

Sequence similarities

Belongs to the CLASP family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,288
  • Mass (Da)
    140,303
  • Last updated
    2004-07-05 v1
  • MD5 Checksum
    DEDB0A1C983924CD18121F9E2BFCFEC7
MALSLSQDRSFDDDDSVDGSRPSSAQAAFKVPKVPKKPAESASSSRRPSATGAAKSGASKEGAGAVDEEDFIKAFTDVPTVQIYSTRDLEDNLNKIREVLSDDKHDWDHRANALKKIRSLLVAGATDYDCFYQHLRLLDGAFKLSAKDLRSQVVREACITVAYLSTLLGNKFDHGAEGIVPVLFNLIPNCAKVMATSGTAAIRIIIRHTHVPRLIPLIASNCTSKSVAVRRRCYEFLDLLLQEWQTHSLERHAAVLVESIKKGIRDADAEARVEARKAYWGLRAHFPGEAESLYNSLESSYQRTLQSCLKSSGSVASLPQSDRSSSSSQESLNRPLSKWSAAPGRVPAGSKSSGSPASLQRSRSDVDVNAAAGAKARHSGQAGGAGRVTTGLTPGSYASLGRLRTKQTLSTASSVGSSQVDSRGRTRSKMASQSQRSDDSDCTPGSQSATPVGAGSRSGSPGRVLASTALSTLSTGAQRVSAAPGSHRRSRIPRSQGCSRDSSPTRLSVAPSNISHIYNGSKGARGSRIPRPSVSQGCSREASRESSRDTSPVRSFTPLGSGLGMSQSSRLSSSVSAMRVLNTGSDVEEALADALKKPARRRYDTYGMYSDDDANSDASSACSERSYSSRNGSIPTYMRQTEDVAEVLNRCASANWSERKEGLMGLQALLKNHRTLSRVELKRLCEIFTRMFADPHSKRDPRGFGTVESGISSASFKRVFSMFLETLVDFIAVHKEDLQDWLFVLLTQLLKKMGADLLGSVQAKVQKALDVTRESFPNDLQFTILMRFTVDQTQTPNLKVKVAILKYIETLTLQMEPQDFVNTGETRLAVSRIITWTTEPKSSDVRKAAQSVLISLFQLNTPEFTMLLGALPKTFQDGATKLLQNHLRNTGNTAQASIGSPLTRHTPRSPASWSSPLTSPTNTSQNTPSPSAFDYDTENMNSEEIYSSLRGVSQAIQNFSVRSQEDMTEPPRKREGDGGEETVDSGRTALDNKTSLLNTMPLLSSSPRPSRDYQPVNYSDSSFGSSSFNKSLKDADQEESLTDDSGVDQSEVVAELLKELSNHSERVEERKAALCELMRLIRETQLHVWDEHFKTILLLLLETLGDGEHVIRALALRVLKEILNRQPWRFKNYAELTIMKALEAHKDPHKEVVRAAEEAASMLATSISPDQCIKVLCPIIQSADYPINLAAIKMLTKVIDRLPKEGLIQMLPEIVPGLIQGYDNSESSVRKACVFCLVAIYAVIGEDLKPHLSQLSGSKLKLLNLYIKRAQSGSSGSDQSSDVGGQGL

Computationally mapped potential isoform sequences

There are 42 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A8M6YWB7A0A8M6YWB7_DANREclasp21527
A0A8M9PN82A0A8M9PN82_DANREclasp21498
A0A8M3AKE5A0A8M3AKE5_DANREclasp21556
A0A8M3AKE9A0A8M3AKE9_DANREclasp21549
A0A8M3AKF4A0A8M3AKF4_DANREclasp21538
A0A8M3AKF9A0A8M3AKF9_DANREclasp21506
A0A8M3AKG2A0A8M3AKG2_DANREclasp21484
A0A8M3AKG9A0A8M3AKG9_DANREclasp21283
A0A8M3AL44A0A8M3AL44_DANREclasp21554
A0A8M3AL48A0A8M3AL48_DANREclasp21544
A0A8M3AL54A0A8M3AL54_DANREclasp21534
A0A8M3AL59A0A8M3AL59_DANREclasp21497
A0A8M3AL63A0A8M3AL63_DANREclasp21335
A0A8M3AL68A0A8M3AL68_DANREclasp21261
A0A8M9P1S4A0A8M9P1S4_DANREclasp21484
A0A8M9PRG1A0A8M9PRG1_DANREclasp21533
A0A8M2B6H8A0A8M2B6H8_DANREclasp21520
A0A8M3ASR7A0A8M3ASR7_DANREclasp21557
A0A8M3ASS1A0A8M3ASS1_DANREclasp21554
A0A8M3AST0A0A8M3AST0_DANREclasp21542
A0A8M3AST4A0A8M3AST4_DANREclasp21507
A0A8M3ASU0A0A8M3ASU0_DANREclasp21489
A0A8M3ASU6A0A8M3ASU6_DANREclasp21331
A0A8M3B3Q9A0A8M3B3Q9_DANREclasp21555
A0A8M3B3R3A0A8M3B3R3_DANREclasp21545
A0A8M3B3R7A0A8M3B3R7_DANREclasp21535
A0A8M3B3S1A0A8M3B3S1_DANREclasp21503
A0A8M3B3S4A0A8M3B3S4_DANREclasp21482
A0A8M3B3S6A0A8M3B3S6_DANREclasp21262
A0A8M3AVR1A0A8M3AVR1_DANREclasp21562
A0A8M3AVR6A0A8M3AVR6_DANREclasp21554
A0A8M3AVS1A0A8M3AVS1_DANREclasp21543
A0A8M3AVS6A0A8M3AVS6_DANREclasp21511
A0A8M3AVT1A0A8M3AVT1_DANREclasp21490
A0A8M3AVT7A0A8M3AVT7_DANREclasp21332
A0A8M9PAW3A0A8M9PAW3_DANREclasp21547
A0A8M9PAW8A0A8M9PAW8_DANREclasp21483
A0A8M6YUG3A0A8M6YUG3_DANREclasp21562
A0A8M6YTV4A0A8M6YTV4_DANREclasp21456
A0A8M1P4L0A0A8M1P4L0_DANREclasp21563
A0A8M9PGC3A0A8M9PGC3_DANREclasp21534
A0A8M6Z2X8A0A8M6Z2X8_DANREclasp21492

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias314-336Polar residues
Compositional bias351-365Polar residues
Compositional bias392-481Polar residues
Compositional bias496-520Polar residues
Compositional bias549-571Polar residues
Compositional bias966-987Basic and acidic residues
Compositional bias988-1031Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BC066436
EMBL· GenBank· DDBJ
AAH66436.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help