Q6NX08 · WDR12_DANRE

Function

function

Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentnucleolus
Cellular Componentnucleoplasm
Cellular ComponentPeBoW complex
Cellular Componentpreribosome, large subunit precursor
Molecular Functionribonucleoprotein complex binding
Biological Processmaturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Biological Processmaturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Biological Processregulation of cell cycle

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Ribosome biogenesis protein wdr12
  • Alternative names
    • WD repeat-containing protein 12

Gene names

    • Name
      wdr12

Organism names

  • Taxonomic identifier
  • Strain
    • AB
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio

Accessions

  • Primary accession
    Q6NX08
  • Secondary accessions
    • Q803T7

Proteomes

Organism-specific databases

Subcellular Location

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00003540811-422Ribosome biogenesis protein wdr12

Proteomic databases

Expression

Gene expression databases

Interaction

Subunit

Component of the PeBoW complex, composed of bop1, pes1 and wdr12. The complex is held together by bop1, which interacts with pes1 via its N-terminal domain and with wdr12 via a high-affinity interaction between the seven-bladed beta-propeller domains of the 2 proteins. The PeBoW complex associates with the 66S pre-ribosome. Interacts (via UBL domain) with mdn1 (via VWFA/MIDAS domain).

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, repeat, compositional bias.

TypeIDPosition(s)Description
Region4-87Ubiquitin-like (UBL) domain
Repeat99-136WD 1
Repeat138-180WD 2
Repeat187-226WD 3
Compositional bias220-241Basic and acidic residues
Region220-243Disordered
Repeat254-292WD 4
Repeat294-333WD 5
Repeat339-379WD 6
Repeat383-421WD 7

Sequence similarities

Belongs to the WD repeat WDR12/YTM1 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    422
  • Mass (Da)
    47,281
  • Last updated
    2004-07-05 v1
  • Checksum
    876368628F120878
MSQLQARFFTENKKYLVDDVPFSIPASSEVADLSGVINKLLEAKNAGHKHVEFDFLVRGQFLRTSLDKHIETENISTEEVVEIEYVEKFTAPQPEECIMHDDWISSVEADSEWILTGSYDKTARIWSMEGKAVMTVAGHADVVKDVAWVKRDGLNSVLLTASLDQTVMLWEWNSERNKVKARHCCRGHAGSVDTIAVDPTRTKFCSGSWDKMLKIWSAVPTEEEDEIEEPNRPRKKQKTEQMGLTRTPLMTLSGHNEAVSSVLWMDADELCSASWDHTIRLWDAETGGQKSTLSGSKVFNCISYSPLCRRLASGSTDRHVRLWDPRSKDGSLVLLSLTSHNGWVTAVRWAPSHEHQLVSGSLDNVVKLWDTRSCKAPLYDLAAHEDKVLCADWTENGLILSGGADNKLYTYRYAACVSDAGA

Features

Showing features for compositional bias, sequence conflict.

TypeIDPosition(s)Description
Compositional bias220-241Basic and acidic residues
Sequence conflict231in Ref. 1; AAH44198

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BC044198
EMBL· GenBank· DDBJ
AAH44198.1
EMBL· GenBank· DDBJ
mRNA
BC067331
EMBL· GenBank· DDBJ
AAH67331.1
EMBL· GenBank· DDBJ
mRNA
BC155268
EMBL· GenBank· DDBJ
AAI55269.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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