Q6NWU0 · Q6NWU0_HUMAN
- ProteinCytochrome P450
- GeneCYP2D6
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids497 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score2/5
Function
function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Cofactor
Features
Showing features for binding site.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum membrane | |
Molecular Function | aromatase activity | |
Molecular Function | heme binding | |
Molecular Function | iron ion binding |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCytochrome P450
- EC number
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ6NWU0
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 6-23 | Helical | ||||
Sequence: LVPLAVIVAIFLLLVDLM |
Keywords
- Cellular component
Disease & Variants
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 1,054 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Genetic variation databases
Structure
Sequence
- Sequence statusComplete
- Length497
- Mass (Da)55,730
- Last updated2004-07-05 v1
- Checksum484E013AE3E6D1C9
Computationally mapped potential isoform sequences
There are 8 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
P10635 | CP2D6_HUMAN | CYP2D6 | 497 | ||
A0A0U1RQH0 | A0A0U1RQH0_HUMAN | CYP2D6 | 240 | ||
A0A1B0GV74 | A0A1B0GV74_HUMAN | CYP2D6 | 446 | ||
A0A0G2JS23 | A0A0G2JS23_HUMAN | CYP2D6 | 180 | ||
C1ID54 | C1ID54_HUMAN | CYP2D6 | 497 | ||
H7BY38 | H7BY38_HUMAN | CYP2D6 | 240 | ||
Q38LG0 | Q38LG0_HUMAN | CYP2D6 | 497 | ||
A0A0G2JLK7 | A0A0G2JLK7_HUMAN | CYP2D6 | 446 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BC067432 EMBL· GenBank· DDBJ | AAH67432.1 EMBL· GenBank· DDBJ | mRNA | ||
BC126858 EMBL· GenBank· DDBJ | AAI26859.1 EMBL· GenBank· DDBJ | mRNA | ||
DQ282147 EMBL· GenBank· DDBJ | ABB77898.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DQ282156 EMBL· GenBank· DDBJ | ABB77904.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DQ282160 EMBL· GenBank· DDBJ | ABB77908.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU586995 EMBL· GenBank· DDBJ | ADF36226.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU587005 EMBL· GenBank· DDBJ | ADF36236.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU587008 EMBL· GenBank· DDBJ | ADF36239.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU587009 EMBL· GenBank· DDBJ | ADF36240.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU587010 EMBL· GenBank· DDBJ | ADF36241.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU587011 EMBL· GenBank· DDBJ | ADF36242.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU587012 EMBL· GenBank· DDBJ | ADF36243.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU587013 EMBL· GenBank· DDBJ | ADF36244.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU587018 EMBL· GenBank· DDBJ | ADF36249.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU587021 EMBL· GenBank· DDBJ | ADF36252.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU587022 EMBL· GenBank· DDBJ | ADF36253.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU587028 EMBL· GenBank· DDBJ | ADF36259.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU587029 EMBL· GenBank· DDBJ | ADF36260.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU587030 EMBL· GenBank· DDBJ | ADF36261.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU587031 EMBL· GenBank· DDBJ | ADF36262.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU587036 EMBL· GenBank· DDBJ | ADF36267.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU587037 EMBL· GenBank· DDBJ | ADF36268.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU587050 EMBL· GenBank· DDBJ | ADF36281.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU587052 EMBL· GenBank· DDBJ | ADF36283.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU587059 EMBL· GenBank· DDBJ | ADF36290.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU587062 EMBL· GenBank· DDBJ | ADF36293.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU587064 EMBL· GenBank· DDBJ | ADF36295.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU587066 EMBL· GenBank· DDBJ | ADF36297.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU587069 EMBL· GenBank· DDBJ | ADF36299.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU587075 EMBL· GenBank· DDBJ | ADF36304.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU587079 EMBL· GenBank· DDBJ | ADF36308.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU587081 EMBL· GenBank· DDBJ | ADF36310.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU587093 EMBL· GenBank· DDBJ | ADF36322.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU587094 EMBL· GenBank· DDBJ | ADF36323.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU587104 EMBL· GenBank· DDBJ | ADF36332.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU587114 EMBL· GenBank· DDBJ | ADF36342.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU587115 EMBL· GenBank· DDBJ | ADF36343.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU587118 EMBL· GenBank· DDBJ | ADF36346.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU587129 EMBL· GenBank· DDBJ | ADF36356.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU587132 EMBL· GenBank· DDBJ | ADF36359.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU587133 EMBL· GenBank· DDBJ | ADF36360.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU587135 EMBL· GenBank· DDBJ | ADF36362.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU587136 EMBL· GenBank· DDBJ | ADF36363.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU587138 EMBL· GenBank· DDBJ | ADF36364.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU587139 EMBL· GenBank· DDBJ | ADF36365.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU587141 EMBL· GenBank· DDBJ | ADF36367.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU587144 EMBL· GenBank· DDBJ | ADF36370.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU587148 EMBL· GenBank· DDBJ | ADF36374.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU587152 EMBL· GenBank· DDBJ | ADF36378.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU587154 EMBL· GenBank· DDBJ | ADF36380.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU587173 EMBL· GenBank· DDBJ | ADF36399.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU587178 EMBL· GenBank· DDBJ | ADF36404.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU587180 EMBL· GenBank· DDBJ | ADF36406.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU587183 EMBL· GenBank· DDBJ | ADF36409.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU587184 EMBL· GenBank· DDBJ | ADF36410.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU587195 EMBL· GenBank· DDBJ | ADF36421.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU587198 EMBL· GenBank· DDBJ | ADF36424.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU587199 EMBL· GenBank· DDBJ | ADF36425.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU587201 EMBL· GenBank· DDBJ | ADF36427.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU587206 EMBL· GenBank· DDBJ | ADF36432.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU587207 EMBL· GenBank· DDBJ | ADF36433.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU587208 EMBL· GenBank· DDBJ | ADF36434.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU587212 EMBL· GenBank· DDBJ | ADF36438.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU587213 EMBL· GenBank· DDBJ | ADF36439.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU587216 EMBL· GenBank· DDBJ | ADF36442.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU587218 EMBL· GenBank· DDBJ | ADF36444.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU587219 EMBL· GenBank· DDBJ | ADF36445.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU587220 EMBL· GenBank· DDBJ | ADF36446.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU587221 EMBL· GenBank· DDBJ | ADF36447.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU587225 EMBL· GenBank· DDBJ | ADF36451.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU587231 EMBL· GenBank· DDBJ | ADF36457.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU587240 EMBL· GenBank· DDBJ | ADF36466.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU587241 EMBL· GenBank· DDBJ | ADF36467.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU587243 EMBL· GenBank· DDBJ | ADF36469.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU587247 EMBL· GenBank· DDBJ | ADF36473.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU587249 EMBL· GenBank· DDBJ | ADF36475.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU587253 EMBL· GenBank· DDBJ | ADF36479.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU587254 EMBL· GenBank· DDBJ | ADF36480.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ421296 EMBL· GenBank· DDBJ | AFB69499.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JN716373 EMBL· GenBank· DDBJ | AFC77926.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JN716374 EMBL· GenBank· DDBJ | AFC77927.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JN716375 EMBL· GenBank· DDBJ | AFC77928.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JN716376 EMBL· GenBank· DDBJ | AFC77929.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF751826 EMBL· GenBank· DDBJ | AIA09568.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KR005632 EMBL· GenBank· DDBJ | AKH44766.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU531563 EMBL· GenBank· DDBJ | ANW61981.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU531564 EMBL· GenBank· DDBJ | ANW61982.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT199339 EMBL· GenBank· DDBJ | QRV61426.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT199340 EMBL· GenBank· DDBJ | QRV61427.1 EMBL· GenBank· DDBJ | Genomic DNA |