Q6NW96 · SP9_DANRE
- ProteinTranscription factor Sp9
- Genesp9
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids439 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
function
Transcription factor which plays a key role in limb development. Positively regulates FGF8 expression in the apical ectodermal ridge (AER) and contributes to limb outgrowth in embryos.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Molecular Function | DNA-binding transcription factor activity, RNA polymerase II-specific | |
Molecular Function | metal ion binding | |
Molecular Function | RNA polymerase II cis-regulatory region sequence-specific DNA binding | |
Biological Process | embryonic limb morphogenesis | |
Biological Process | embryonic pectoral fin morphogenesis | |
Biological Process | positive regulation of fibroblast growth factor receptor signaling pathway | |
Biological Process | regulation of transcription by RNA polymerase II |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameTranscription factor Sp9
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio
Accessions
- Primary accessionQ6NW96
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000395452 | 1-439 | Transcription factor Sp9 | |||
Sequence: MATSILGEEPRFGTTPLAMLAATCNKIGNTSPLTTLPDSSAFSKGGFHPWKRSSSSCNLGSSLPGFTVATSRSTSGLTTTTGAGNSAFCLASTSPTSSAFSAEYSSLFSNTTSVSSQDSGQSAFISKVHSSADTLYPRVGMAHPYESWYKSGFHSTISGDVANGASTWWDVHTNPGSWLEVQNPAGTLQSSLHSGTPQAIHSQLSGYNPDFSSLTHSAFSSTGISPTASHLLSTSQHLLTQEGFKTVIPTYTDASATNAMISGASSGIGTSSRSSRRYSGRATCDCPNCQEAERLGPAGASLRRKGLHSCHIPGCGKVYGKTSHLKAHLRWHTGERPFVCNWLFCGKRFTRSDELQRHLRTHTGEKRFACPVCNKRFMRSDHLSKHIKTHTAGGGGKKGSDSDTDTSNLETPRSESPELILEGVNPRVTVKDQSPHHES |
Proteomic databases
Expression
Developmental stage
Expressed in the forebrain, and in the prospective midbrain/hindbrain boundary during early somitogenesis. As development proceeds, also detected in the hindbrain, as well as in the apical fold of the developing pectoral fin, and this expression extends proximally.
Gene expression databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for motif, zinc finger, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Motif | 166-174 | 9aaTAD; inactive | ||||
Sequence: STWWDVHTN | ||||||
Zinc finger | 308-332 | C2H2-type 1 | ||||
Sequence: HSCHIPGCGKVYGKTSHLKAHLRWH | ||||||
Zinc finger | 338-362 | C2H2-type 2 | ||||
Sequence: FVCNWLFCGKRFTRSDELQRHLRTH | ||||||
Zinc finger | 368-390 | C2H2-type 3 | ||||
Sequence: FACPVCNKRFMRSDHLSKHIKTH | ||||||
Region | 384-439 | Disordered | ||||
Sequence: SKHIKTHTAGGGGKKGSDSDTDTSNLETPRSESPELILEGVNPRVTVKDQSPHHES | ||||||
Compositional bias | 400-414 | Polar residues | ||||
Sequence: SDSDTDTSNLETPRS |
Domain
The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors. In SP9, the motif is inactive.
Sequence similarities
Belongs to the Sp1 C2H2-type zinc-finger protein family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
This entry describes 2 isoforms produced by Alternative splicing.
Q6NW96-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length439
- Mass (Da)46,772
- Last updated2004-07-05 v1
- Checksum32C5DE41A663823F
Q6NW96-2
- Name2
- Differences from canonical
- 1-7: MATSILG → MFYSLVKSTNFSSTQ
Features
Showing features for alternative sequence, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_039468 | 1-7 | in isoform 2 | |||
Sequence: MATSILG → MFYSLVKSTNFSSTQ | ||||||
Compositional bias | 400-414 | Polar residues | ||||
Sequence: SDSDTDTSNLETPRS |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AY591905 EMBL· GenBank· DDBJ | AAU04514.1 EMBL· GenBank· DDBJ | mRNA | ||
AY731230 EMBL· GenBank· DDBJ | AAV34441.1 EMBL· GenBank· DDBJ | mRNA | ||
BC067673 EMBL· GenBank· DDBJ | AAH67673.1 EMBL· GenBank· DDBJ | mRNA |