Q6NW59 · ATF4_DANRE
- ProteinCyclic AMP-dependent transcription factor ATF-4
- Geneatf4
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids339 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score5/5
Function
function
Transcription factor that binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3') and displays two biological functions, as regulator of metabolic and redox processes under normal cellular conditions, and as master transcription factor during integrated stress response (ISR) (By similarity).
Binds to asymmetric CRE's as a heterodimer and to palindromic CRE's as a homodimer (By similarity).
Core effector of the ISR, which is required for adaptation to various stress such as endoplasmic reticulum (ER) stress, amino acid starvation, mitochondrial stress or oxidative stress. During ISR, atf4 translation is induced via an alternative ribosome translation re-initiation mechanism in response to eif2s1/eIF-2-alpha phosphorylation, and stress-induced atf4 acts as a master transcription factor of stress-responsive genes in order to promote cell recovery (By similarity).
Promotes the transcription of genes linked to amino acid sufficiency and resistance to oxidative stress to protect cells against metabolic consequences of ER oxidation (By similarity).
In the absence of stress, atf4 translation is at low levels and it is required for normal metabolic processes such as embryonic lens formation, fetal liver hematopoiesis, bone development and synaptic plasticity (By similarity).
Acts as a regulator of osteoblast differentiation by promoting expression of osteoblast-specific genes (By similarity).
Regulates the circadian expression of the core clock components. Mainly acts as a transcriptional activator in cellular stress adaptation, but it can also act as a transcriptional repressor (By similarity).
Binds to asymmetric CRE's as a heterodimer and to palindromic CRE's as a homodimer (By similarity).
Core effector of the ISR, which is required for adaptation to various stress such as endoplasmic reticulum (ER) stress, amino acid starvation, mitochondrial stress or oxidative stress. During ISR, atf4 translation is induced via an alternative ribosome translation re-initiation mechanism in response to eif2s1/eIF-2-alpha phosphorylation, and stress-induced atf4 acts as a master transcription factor of stress-responsive genes in order to promote cell recovery (By similarity).
Promotes the transcription of genes linked to amino acid sufficiency and resistance to oxidative stress to protect cells against metabolic consequences of ER oxidation (By similarity).
In the absence of stress, atf4 translation is at low levels and it is required for normal metabolic processes such as embryonic lens formation, fetal liver hematopoiesis, bone development and synaptic plasticity (By similarity).
Acts as a regulator of osteoblast differentiation by promoting expression of osteoblast-specific genes (By similarity).
Regulates the circadian expression of the core clock components. Mainly acts as a transcriptional activator in cellular stress adaptation, but it can also act as a transcriptional repressor (By similarity).
GO annotations
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended nameCyclic AMP-dependent transcription factor ATF-4
- Short namescAMP-dependent transcription factor ATF-4
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio
Accessions
- Primary accessionQ6NW59
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000258023 | 1-339 | Cyclic AMP-dependent transcription factor ATF-4 | |||
Sequence: MSLCVGDAGALLLGPWPLTADPQGPLLDQDEESSVLEGSWSPSSSSLSSFSPPASGDAPSELLSLSWQPSDVLLTEQSTAGDVFPGMDWMTEKLDLNDFDLDSLIGSCDSEDSPGSPEDLLACLDSSMDLDLDSLPFGSADLDLPLGLDLPLPEEIKSEPLSPAPSVPSPPEEAPQDEHTEVPVLHPAGIMLSLSPSHIVVLLTPKEEQNISDCSDSDSGISVSGSPAHQSDLEPSSRAKPYSRPDPEASPALKGRVKTSSGAPKVEKKLKKMEQNKTAATRYRQKKRVEQESLNSECSELEKKNRELSEKADSLSREIQYLRDLLEEMRTAKQRKSKR |
Proteomic databases
Expression
Gene expression databases
Interaction
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 14-62 | Disordered | ||||
Sequence: GPWPLTADPQGPLLDQDEESSVLEGSWSPSSSSLSSFSPPASGDAPSEL | ||||||
Compositional bias | 34-62 | Polar residues | ||||
Sequence: SVLEGSWSPSSSSLSSFSPPASGDAPSEL | ||||||
Region | 153-182 | Disordered | ||||
Sequence: PEEIKSEPLSPAPSVPSPPEEAPQDEHTEV | ||||||
Compositional bias | 209-237 | Polar residues | ||||
Sequence: QNISDCSDSDSGISVSGSPAHQSDLEPSS | ||||||
Region | 209-313 | Disordered | ||||
Sequence: QNISDCSDSDSGISVSGSPAHQSDLEPSSRAKPYSRPDPEASPALKGRVKTSSGAPKVEKKLKKMEQNKTAATRYRQKKRVEQESLNSECSELEKKNRELSEKAD | ||||||
Compositional bias | 261-313 | Basic and acidic residues | ||||
Sequence: SGAPKVEKKLKKMEQNKTAATRYRQKKRVEQESLNSECSELEKKNRELSEKAD | ||||||
Domain | 266-329 | bZIP | ||||
Sequence: VEKKLKKMEQNKTAATRYRQKKRVEQESLNSECSELEKKNRELSEKADSLSREIQYLRDLLEEM | ||||||
Region | 268-288 | Basic motif | ||||
Sequence: KKLKKMEQNKTAATRYRQKKR | ||||||
Region | 294-322 | Leucine-zipper | ||||
Sequence: LNSECSELEKKNRELSEKADSLSREIQYL |
Sequence similarities
Belongs to the bZIP family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length339
- Mass (Da)36,605
- Last updated2004-07-05 v1
- ChecksumC3C40B2D17D24CD2
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A8M2BJE3 | A0A8M2BJE3_DANRE | atf4a | 338 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 34-62 | Polar residues | ||||
Sequence: SVLEGSWSPSSSSLSSFSPPASGDAPSEL | ||||||
Compositional bias | 209-237 | Polar residues | ||||
Sequence: QNISDCSDSDSGISVSGSPAHQSDLEPSS | ||||||
Compositional bias | 261-313 | Basic and acidic residues | ||||
Sequence: SGAPKVEKKLKKMEQNKTAATRYRQKKRVEQESLNSECSELEKKNRELSEKAD |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BC067714 EMBL· GenBank· DDBJ | AAH67714.1 EMBL· GenBank· DDBJ | mRNA |