Q6NVU6 · UFSP1_HUMAN
- ProteinUfm1-specific protease 1
- GeneUFSP1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids218 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Thiol-dependent isopeptidase that specifically mediate the processing of UFM1 precursors as well as the deconjugation of UFM1 from target proteins (PubMed:35525273, PubMed:35926457).
Mainly responsible for the maturation of the UFM1 precursor, a prerequisite for conjugation reactions (PubMed:35525273, PubMed:35926457).
Mainly responsible for the maturation of the UFM1 precursor, a prerequisite for conjugation reactions (PubMed:35525273, PubMed:35926457).
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 45 | |||||
Sequence: C | ||||||
Active site | 167 | |||||
Sequence: D | ||||||
Active site | 169 | |||||
Sequence: H |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | cysteine-type peptidase activity | |
Molecular Function | deUFMylase activity | |
Biological Process | protein maturation | |
Biological Process | protein ufmylation | |
Biological Process | proteolysis |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameUfm1-specific protease 1
- EC number
- Short namesUfSP1
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ6NVU6
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Disease & Variants
Features
Showing features for mutagenesis, natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Mutagenesis | 45 | Abolished isopeptidase activity. | ||||
Sequence: C → A | ||||||
Natural variant | VAR_031125 | 123 | in dbSNP:rs12666989 | |||
Sequence: L → V |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 339 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000280360 | 1-218 | Ufm1-specific protease 1 | |||
Sequence: MEPLRDVHVGLSPPSRGPVRLALLSGHYLYYHYGCDGLDDRGWGCGYRTLQTLCSWPEGQPAGVPGLAAVQAALEDMGDKPPGFRGSRDWIGCVEASLCLAHFGGPQGRLCHVPRGVGLHGELERLYSHFAGGGGPVMVGGDADARSKALLGVCVGSGTEAYVLVLDPHYWGTPKSPSELQAAGWVGWQEVSAAFDPNSFYNLCLTSLSSQQQQRTLD |
Proteomic databases
PTM databases
Expression
Interaction
Binary interactions
Protein-protein interaction databases
Miscellaneous
Structure
Sequence
- Sequence statusComplete
- Length218
- Mass (Da)23,253
- Last updated2024-07-24 v3
- ChecksumC9CB6404D95B1BEF
Sequence caution
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF312032 EMBL· GenBank· DDBJ | AAK21004.1 EMBL· GenBank· DDBJ | Genomic DNA | Sequence problems. | |
AK292467 EMBL· GenBank· DDBJ | BAF85156.1 EMBL· GenBank· DDBJ | mRNA | Sequence problems. | |
CH236956 EMBL· GenBank· DDBJ | EAL23814.1 EMBL· GenBank· DDBJ | Genomic DNA | Sequence problems. | |
AC011895 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BC067904 EMBL· GenBank· DDBJ | AAH67904.1 EMBL· GenBank· DDBJ | mRNA | Sequence problems. |