Q6NVU6 · UFSP1_HUMAN

  • Protein
    Ufm1-specific protease 1
  • Gene
    UFSP1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Thiol-dependent isopeptidase that specifically mediate the processing of UFM1 precursors as well as the deconjugation of UFM1 from target proteins (PubMed:35525273, PubMed:35926457).
Mainly responsible for the maturation of the UFM1 precursor, a prerequisite for conjugation reactions (PubMed:35525273, PubMed:35926457).

Caution

UFSP1 initiates at a non-canonical GUG codon (PubMed:35525273, PubMed:35926457).
Was initially thought to initiate from Met-77 and constitute a inactive isopeptidase that lacks a functional protease domain (PubMed:35525273, PubMed:35926457).

Features

Showing features for active site.

121820406080100120140160180200
TypeIDPosition(s)Description
Active site45
Active site167
Active site169

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functioncysteine-type peptidase activity
Molecular FunctiondeUFMylase activity
Biological Processprotein maturation
Biological Processprotein ufmylation
Biological Processproteolysis

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Ufm1-specific protease 1
  • EC number
  • Short names
    UfSP1

Gene names

    • Name
      UFSP1

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q6NVU6
  • Secondary accessions
    • A0A5F9ZGY7
    • A4D2E4
    • A8K8V2
    • B6ZDG6
    • Q9BXP6

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Disease & Variants

Features

Showing features for mutagenesis, natural variant.

TypeIDPosition(s)Description
Mutagenesis45Abolished isopeptidase activity.
Natural variantVAR_031125123in dbSNP:rs12666989

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 339 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002803601-218Ufm1-specific protease 1

Proteomic databases

PTM databases

Expression

Gene expression databases

Organism-specific databases

Interaction

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY Q6NVU6C10orf55 Q5SWW73EBI-12068150, EBI-12809220
BINARY Q6NVU6CIDEB Q9UHD43EBI-12068150, EBI-7062247
BINARY Q6NVU6CIDEC Q96AQ73EBI-12068150, EBI-14151404
BINARY Q6NVU6COG6 Q9Y2V73EBI-12068150, EBI-3866319
BINARY Q6NVU6CREB5 Q02930-33EBI-12068150, EBI-10192698
BINARY Q6NVU6CSTF2 P332403EBI-12068150, EBI-711360
BINARY Q6NVU6FAM222B Q8WU583EBI-12068150, EBI-2807642
BINARY Q6NVU6FANCL Q9NW383EBI-12068150, EBI-2339898
BINARY Q6NVU6FOXH1 O755933EBI-12068150, EBI-1759806
BINARY Q6NVU6FOXI1 Q12951-23EBI-12068150, EBI-12018822
BINARY Q6NVU6GLYCTK Q8IVS83EBI-12068150, EBI-748515
BINARY Q6NVU6GPSM3 Q9Y4H43EBI-12068150, EBI-347538
BINARY Q6NVU6HNF1B P356803EBI-12068150, EBI-2798841
BINARY Q6NVU6HOXC9 P312743EBI-12068150, EBI-1779423
BINARY Q6NVU6HSF4 Q9ULV5-23EBI-12068150, EBI-12056251
BINARY Q6NVU6INCA1 Q0VD863EBI-12068150, EBI-6509505
BINARY Q6NVU6KRTAP15-1 Q3LI763EBI-12068150, EBI-11992140
BINARY Q6NVU6LASP1 Q14847-23EBI-12068150, EBI-9088686
BINARY Q6NVU6MSRB3 Q8IXL7-23EBI-12068150, EBI-10699187
BINARY Q6NVU6MYOZ3 Q8TDC03EBI-12068150, EBI-5662487
BINARY Q6NVU6PITX1 P783373EBI-12068150, EBI-748265
BINARY Q6NVU6PITX2 Q99697-23EBI-12068150, EBI-12138495
BINARY Q6NVU6POGZ Q7Z3K33EBI-12068150, EBI-1389308
BINARY Q6NVU6POU6F2 P784243EBI-12068150, EBI-12029004
BINARY Q6NVU6PROP1 O753603EBI-12068150, EBI-9027467
BINARY Q6NVU6RBPMS2 Q6ZRY43EBI-12068150, EBI-11987469
BINARY Q6NVU6RUSC1 Q9BVN23EBI-12068150, EBI-6257312
BINARY Q6NVU6SMARCC1 Q929223EBI-12068150, EBI-355653
BINARY Q6NVU6SNRPC P092343EBI-12068150, EBI-766589
BINARY Q6NVU6SPG21 Q9NZD83EBI-12068150, EBI-742688
BINARY Q6NVU6TBX3 O151193EBI-12068150, EBI-3452216
BINARY Q6NVU6TCF7L2 Q9NQB0-103EBI-12068150, EBI-11746252
BINARY Q6NVU6TLX3 O437113EBI-12068150, EBI-3939165
BINARY Q6NVU6UBQLN2 Q9UHD93EBI-12068150, EBI-947187
BINARY Q6NVU6VAC14 Q08AM63EBI-12068150, EBI-2107455
BINARY Q6NVU6VAX2 Q9UIW03EBI-12068150, EBI-12090999
BINARY Q6NVU6VGLL3 A8MV65-23EBI-12068150, EBI-11957216
BINARY Q6NVU6VPS37C A5D8V63EBI-12068150, EBI-2559305
BINARY Q6NVU6WWOX Q9NZC7-53EBI-12068150, EBI-12040603
BINARY Q6NVU6ZIC1 Q159153EBI-12068150, EBI-11963196

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Sequence similarities

Belongs to the peptidase C78 family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    218
  • Mass (Da)
    23,253
  • Last updated
    2024-07-24 v3
  • Checksum
    C9CB6404D95B1BEF
MEPLRDVHVGLSPPSRGPVRLALLSGHYLYYHYGCDGLDDRGWGCGYRTLQTLCSWPEGQPAGVPGLAAVQAALEDMGDKPPGFRGSRDWIGCVEASLCLAHFGGPQGRLCHVPRGVGLHGELERLYSHFAGGGGPVMVGGDADARSKALLGVCVGSGTEAYVLVLDPHYWGTPKSPSELQAAGWVGWQEVSAAFDPNSFYNLCLTSLSSQQQQRTLD

Sequence caution

The sequence AAH67904.1 differs from that shown. Reason: Miscellaneous discrepancy Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.
The sequence AAK21004.1 differs from that shown. Reason: Miscellaneous discrepancy Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.
The sequence BAF85156.1 differs from that shown. Reason: Miscellaneous discrepancy Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.
The sequence EAL23814.1 differs from that shown. Reason: Erroneous gene model prediction

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF312032
EMBL· GenBank· DDBJ
AAK21004.1
EMBL· GenBank· DDBJ
Genomic DNA Sequence problems.
AK292467
EMBL· GenBank· DDBJ
BAF85156.1
EMBL· GenBank· DDBJ
mRNA Sequence problems.
CH236956
EMBL· GenBank· DDBJ
EAL23814.1
EMBL· GenBank· DDBJ
Genomic DNA Sequence problems.
AC011895
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
BC067904
EMBL· GenBank· DDBJ
AAH67904.1
EMBL· GenBank· DDBJ
mRNA Sequence problems.

Genome annotation databases

Similar Proteins

Disclaimer

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