Q6NKR2 · TPMT2_ARATH
- ProteinPhosphatidylglycerophosphate phosphatase PTPMT2
- GenePTPMT2
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids228 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Exhibits phosphatidylglycerophosphate phosphatase activity (PubMed:29476828).
Involved in root growth and columella cells organization (PubMed:29476828).
May possess protein phosphatase activity (By similarity).
Involved in root growth and columella cells organization (PubMed:29476828).
May possess protein phosphatase activity (By similarity).
Catalytic activity
- O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate
Pathway
Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 2/2.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 48 | substrate | |||
Binding site | 126 | substrate | |||
Active site | 157 | Phosphocysteine intermediate | |||
Binding site | 158-163 | substrate | |||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | myosin phosphatase activity | |
Molecular Function | phosphatidylglycerophosphatase activity | |
Molecular Function | protein tyrosine phosphatase activity | |
Biological Process | phosphatidylglycerol biosynthetic process | |
Biological Process | protein dephosphorylation | |
Biological Process | root development |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePhosphatidylglycerophosphate phosphatase PTPMT2
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis
Accessions
- Primary accessionQ6NKR2
- Secondary accessions
Proteomes
Organism-specific databases
Genome annotation databases
Phenotypes & Variants
Disruption phenotype
No visible phenotype in the double mutant ptpmt1-1 ptpmt2-1 (PubMed:29476828).
But plants lacking PTPMT1, PTPMT2 and PGPP1 have strongly shorter roots associated with a defective order of columella cells in the root apices, with stronger effect than in the single mutant pgpp1-1 (PubMed:29476828).
But plants lacking PTPMT1, PTPMT2 and PGPP1 have strongly shorter roots associated with a defective order of columella cells in the root apices, with stronger effect than in the single mutant pgpp1-1 (PubMed:29476828).
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 26 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000449815 | 1-228 | Phosphatidylglycerophosphate phosphatase PTPMT2 | ||
Proteomic databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain, motif.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 1-30 | Disordered | |||
Compositional bias | 7-30 | Basic and acidic residues | |||
Domain | 66-213 | Tyrosine-protein phosphatase | |||
Motif | 157-163 | Glucan phosphatase signature motif CXAGXGR | |||
Sequence similarities
Phylogenomic databases
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
This entry describes 2 isoforms produced by Alternative splicing.
Q6NKR2-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- SynonymsPTPMT2.1
- Length228
- Mass (Da)25,726
- Last updated2004-07-05 v1
- ChecksumFA6B196784943CE4
Q6NKR2-2
- Name2
- SynonymsPTPMT2.2
- Differences from canonical
- 73-113: Missing
Sequence caution
Features
Showing features for compositional bias, alternative sequence.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 7-30 | Basic and acidic residues | |||
Alternative sequence | VSP_060573 | 73-113 | in isoform 2 | ||
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
FJ605096 EMBL· GenBank· DDBJ | ACU43460.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AB013392 EMBL· GenBank· DDBJ | BAB09879.1 EMBL· GenBank· DDBJ | Genomic DNA | Sequence problems. | |
CP002688 EMBL· GenBank· DDBJ | AED96787.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002688 EMBL· GenBank· DDBJ | AED96788.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BT012631 EMBL· GenBank· DDBJ | AAT06450.1 EMBL· GenBank· DDBJ | mRNA | ||
AK221735 EMBL· GenBank· DDBJ | BAD93755.1 EMBL· GenBank· DDBJ | mRNA |