Q6NKR2 · TPMT2_ARATH

Function

function

Exhibits phosphatidylglycerophosphate phosphatase activity (PubMed:29476828).
Involved in root growth and columella cells organization (PubMed:29476828).
May possess protein phosphatase activity (By similarity).

Catalytic activity

Pathway

Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 2/2.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site48substrate
Binding site126substrate
Active site157Phosphocysteine intermediate
Binding site158-163substrate

GO annotations

AspectTerm
Molecular Functionmyosin phosphatase activity
Molecular Functionphosphatidylglycerophosphatase activity
Molecular Functionprotein tyrosine phosphatase activity
Biological Processphosphatidylglycerol biosynthetic process
Biological Processprotein dephosphorylation
Biological Processroot development

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphatidylglycerophosphate phosphatase PTPMT2
  • EC number
  • Alternative names
    • Protein TYROSINE PHOSPHATASE LOCALIZED TO THE MITOCHONDRION 2
    • Putative dual specificity protein phosphatase PTPMT2
      (EC:3.1.3.16
      , EC:3.1.3.48
      ) . EC:3.1.3.16 (UniProtKB | ENZYME | Rhea)
      , EC:3.1.3.48 (UniProtKB | ENZYME | Rhea)

Gene names

    • Name
      PTPMT2
    • Synonyms
      PTP133
    • ORF names
      MIK19.6
    • Ordered locus names
      At5g56610

Organism names

  • Taxonomic identifier
  • Strain
    • cv. Columbia
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis

Accessions

  • Primary accession
    Q6NKR2
  • Secondary accessions
    • F4K7Q7
    • Q9FJU7

Proteomes

Organism-specific databases

Genome annotation databases

Phenotypes & Variants

Disruption phenotype

No visible phenotype in the double mutant ptpmt1-1 ptpmt2-1 (PubMed:29476828).
But plants lacking PTPMT1, PTPMT2 and PGPP1 have strongly shorter roots associated with a defective order of columella cells in the root apices, with stronger effect than in the single mutant pgpp1-1 (PubMed:29476828).

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 26 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004498151-228Phosphatidylglycerophosphate phosphatase PTPMT2

Proteomic databases

Expression

Tissue specificity

Isoform 1

Expressed in roots, leaves, stems and flowers.

Isoform 2

Expressed at low levels in stems and flowers.

Gene expression databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, compositional bias, domain, motif.

Type
IDPosition(s)Description
Region1-30Disordered
Compositional bias7-30Basic and acidic residues
Domain66-213Tyrosine-protein phosphatase
Motif157-163Glucan phosphatase signature motif CXAGXGR

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

Q6NKR2-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Name
    1
  • Synonyms
    PTPMT2.1
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Length
    228
  • Mass (Da)
    25,726
  • Last updated
    2004-07-05 v1
  • Checksum
    FA6B196784943CE4
MTDETEEDDTTQQRSSRNDGVSKNKGKGFKGDKAKRALIGAGGRILFYPTLLYNLVRFKLQSQFRWWDQIDEYLLMGAVPFRKDVPRLKKLGVGGVITLNEPYETLVPSSLYSAYEMEHLVIPTRDYLFAPSIVDITLAVNFIHKNALLGKTTYVHCKAGRGRSTTVVLCYLIEHKSMTVAAAFEHVRSIRPRVLLHPSQRKVVEEFSRLQSPLSESTFIATSGDIVS

Q6NKR2-2

  • Name
    2
  • Synonyms
    PTPMT2.2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Sequence caution

The sequence BAB09879.1 differs from that shown. Reason: Erroneous gene model prediction

Features

Showing features for compositional bias, alternative sequence.

Type
IDPosition(s)Description
Compositional bias7-30Basic and acidic residues
Alternative sequenceVSP_06057373-113in isoform 2

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
FJ605096
EMBL· GenBank· DDBJ
ACU43460.1
EMBL· GenBank· DDBJ
Genomic DNA
AB013392
EMBL· GenBank· DDBJ
BAB09879.1
EMBL· GenBank· DDBJ
Genomic DNA Sequence problems.
CP002688
EMBL· GenBank· DDBJ
AED96787.1
EMBL· GenBank· DDBJ
Genomic DNA
CP002688
EMBL· GenBank· DDBJ
AED96788.1
EMBL· GenBank· DDBJ
Genomic DNA
BT012631
EMBL· GenBank· DDBJ
AAT06450.1
EMBL· GenBank· DDBJ
mRNA
AK221735
EMBL· GenBank· DDBJ
BAD93755.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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