Q6NHJ8 · COAD_CORDI
- ProteinPhosphopantetheine adenylyltransferase
- GenecoaD
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids159 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
Catalytic activity
- (R)-4'-phosphopantetheine + ATP + H+ = 3'-dephospho-CoA + diphosphate
Cofactor
Pathway
Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 4/5.
Features
Showing features for binding site, site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 9 | substrate | ||||
Sequence: S | ||||||
Binding site | 9-10 | ATP (UniProtKB | ChEBI) | ||||
Sequence: SF | ||||||
Binding site | 17 | ATP (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Site | 17 | Transition state stabilizer | ||||
Sequence: H | ||||||
Binding site | 41 | substrate | ||||
Sequence: K | ||||||
Binding site | 74 | substrate | ||||
Sequence: L | ||||||
Binding site | 88 | substrate | ||||
Sequence: K | ||||||
Binding site | 89-91 | ATP (UniProtKB | ChEBI) | ||||
Sequence: GLR | ||||||
Binding site | 99 | ATP (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 123-129 | ATP (UniProtKB | ChEBI) | ||||
Sequence: YGYISST |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | ATP binding | |
Molecular Function | pantetheine-phosphate adenylyltransferase activity | |
Biological Process | coenzyme A biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePhosphopantetheine adenylyltransferase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Mycobacteriales > Corynebacteriaceae > Corynebacterium
Accessions
- Primary accessionQ6NHJ8
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000156197 | 1-159 | Phosphopantetheine adenylyltransferase | |||
Sequence: MRKAVCPGSFDPVTMGHLDIIGRAAQQYDEVTVLVTANPNKPSGMFTVDERLALIKESTAHFVNVKVDNWAGLLVDYTTANGIDAIVKGLRTALDYEYELPMAQMNRKLAGVDTLFLMTDPQYGYISSTLCKEVTKYGGDVSDMLPPAVAAAIVEKVKS |
Interaction
Structure
Sequence
- Sequence statusComplete
- Length159
- Mass (Da)17,305
- Last updated2004-07-05 v1
- ChecksumF92BB71DD405E7E0
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BX248357 EMBL· GenBank· DDBJ | CAE49659.1 EMBL· GenBank· DDBJ | Genomic DNA |