Q6NFN7 · IXTPA_CORDI

Function

function

Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site7-12substrate
Active site72Proton acceptor
Binding site72Mg2+ (UniProtKB | ChEBI)
Binding site73substrate
Binding site155-158substrate
Binding site183substrate
Binding site188-189substrate

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctiondITP diphosphatase activity
Molecular FunctionITP diphosphatase activity
Molecular Functionmetal ion binding
Molecular Functionnucleotide binding
Molecular Functionribonucleoside triphosphate phosphatase activity
Molecular FunctionXTP diphosphatase activity
Biological Processnucleotide metabolic process
Biological Processpurine nucleoside triphosphate catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    dITP/XTP pyrophosphatase
  • EC number
  • Alternative names
    • Non-canonical purine NTP pyrophosphatase
    • Non-standard purine NTP pyrophosphatase
    • Nucleoside-triphosphate diphosphatase
    • Nucleoside-triphosphate pyrophosphatase
      (NTPase
      )

Gene names

    • Ordered locus names
      DIP1850

Organism names

Accessions

  • Primary accession
    Q6NFN7

Proteomes

Subcellular Location

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001781571-207dITP/XTP pyrophosphatase

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the HAM1 NTPase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    207
  • Mass (Da)
    22,032
  • Last updated
    2004-07-05 v1
  • Checksum
    6EA838BB675E59BB
MKVLVASNNAKKLGELRTILENAGLSSVEVVPLSAIDAYDEPVEDGRTFADNALIKARAGAHHSGLITIADDSGFAVEELNGMPGVLSARWSGQHGNDATNNELVLAQMKHVPEERRHAAFVSVCALVTPDGDEHIVEGRWEGRMLTAPRGANGFGYDPLFVPAEEDAAGTGRTSAEMSPAEKNAISHRGKALQQLVPIIAGYSTFF

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BX248359
EMBL· GenBank· DDBJ
CAE50379.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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