Q6N7S7 · XGPT_RHOPA

Function

function

Purine salvage pathway enzyme that catalyzes the transfer of the ribosyl-5-phosphate group from 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to the N9 position of the 6-oxopurines guanine and xanthine to form the corresponding ribonucleotides GMP (guanosine 5'-monophosphate) and XMP (xanthosine 5'-monophosphate), with the release of PPi. To a lesser extent, also acts on hypoxanthine.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Pathway

Purine metabolism; GMP biosynthesis via salvage pathway; GMP from guanine: step 1/1.
Purine metabolism; XMP biosynthesis via salvage pathway; XMP from xanthine: step 1/1.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site48-495-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI)
Binding site107-1155-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI)
Binding site108Mg2+ (UniProtKB | ChEBI)
Binding site111guanine (UniProtKB | ChEBI)
Binding site111xanthine (UniProtKB | ChEBI)
Binding site111-115GMP (UniProtKB | ChEBI)
Binding site153-154GMP (UniProtKB | ChEBI)
Binding site154guanine (UniProtKB | ChEBI)
Binding site154xanthine (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular Functionguanine phosphoribosyltransferase activity
Molecular Functionhypoxanthine phosphoribosyltransferase activity
Molecular Functionmagnesium ion binding
Molecular Functionxanthine phosphoribosyltransferase activity
Biological ProcessGMP salvage
Biological Processpurine ribonucleoside salvage
Biological ProcessXMP salvage

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Xanthine-guanine phosphoribosyltransferase
  • EC number
  • Short names
    XGPRT
  • Alternative names
    • Xanthine phosphoribosyltransferase

Gene names

    • Name
      gpt
    • Ordered locus names
      RPA2179

Organism names

Accessions

  • Primary accession
    Q6N7S7

Subcellular Location

Cell inner membrane
; Peripheral membrane protein

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001396821-173Xanthine-guanine phosphoribosyltransferase

Interaction

Subunit

Homotetramer.

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    173
  • Mass (Da)
    18,917
  • Last updated
    2005-12-20 v2
  • Checksum
    5A29A210C4882932
MTQSEPTEQKRAGRPFPVSWDQFHRDCRALSWRLNELGPFHAVIAITRGGLVPAAIVARELGLRVIDTVCIASYEHDKQGELQVLKGVSDQTATLGGGTGKGLLIIDDLVDTGKTGRMVRSMLPDAHFAAVYAKPKGRPLVDTFITEVSQDTWIFFPWDTGLSFQPPLKDGAG

Sequence caution

The sequence CAE27620.1 differs from that shown. Reason: Erroneous initiation

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BX572600
EMBL· GenBank· DDBJ
CAE27620.1
EMBL· GenBank· DDBJ
Genomic DNA Different initiation

Genome annotation databases

Similar Proteins

Disclaimer

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