Q6N2N5 · SAHH_RHOPA
- ProteinAdenosylhomocysteinase
- GeneahcY
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids469 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.
Catalytic activity
- S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine
Cofactor
Note: Binds 1 NAD+ per subunit.
Pathway
Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 58 | substrate | |||
Binding site | 133 | substrate | |||
Binding site | 195 | substrate | |||
Binding site | 196-198 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 225 | substrate | |||
Binding site | 229 | substrate | |||
Binding site | 230 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 259-264 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 282 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 317 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 338-340 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 383 | NAD+ (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | adenosylhomocysteinase activity | |
Biological Process | L-homocysteine biosynthetic process | |
Biological Process | one-carbon metabolic process | |
Biological Process | S-adenosylmethionine cycle |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAdenosylhomocysteinase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Alphaproteobacteria > Hyphomicrobiales > Nitrobacteraceae > Rhodopseudomonas
Accessions
- Primary accessionQ6N2N5
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000116984 | 1-469 | Adenosylhomocysteinase | ||
Interaction
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length469
- Mass (Da)51,699
- Last updated2004-07-05 v1
- MD5 Checksum705F37287400BBBC2F129DE32117AC5F
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BX572606 EMBL· GenBank· DDBJ | CAE29456.1 EMBL· GenBank· DDBJ | Genomic DNA |