Q6N063 · OGFD2_HUMAN
- Protein2-oxoglutarate and iron-dependent oxygenase domain-containing protein 2
- GeneOGFOD2
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids350 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
Cofactor
Protein has several cofactor binding sites:
Note: Binds 1 Fe2+ ion per subunit.
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | dioxygenase activity | |
Molecular Function | iron ion binding | |
Molecular Function | L-ascorbic acid binding | |
Molecular Function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name2-oxoglutarate and iron-dependent oxygenase domain-containing protein 2
- EC number
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ6N063
- Secondary accessions
Proteomes
Organism-specific databases
Disease & Variants
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 527 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Chemistry
Genetic variation databases
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000288978 | 1-350 | 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 2 | |||
Sequence: MATVGAPRHFCRCACFCTDNLYVARYGLHVRFRGEQQLRRDYGPILRSRGCVSAKDFQQLLAELEQEVERRQRLGQESAARKALIASSYHPARPEVYDSLQDAALAPEFLAVTEYSVSPDADLKGLLQRLETVSEEKRIYRVPVFTAPFCQALLEELEHFEQSDMPKGRPNTMNNYGVLLHELGLDEPLMTPLRERFLQPLMALLYPDCGGGRLDSHRAFVVKYAPGQDLELGCHYDNAELTLNVALGKVFTGGALYFGGLFQAPTALTEPLEVEHVVGQGVLHRGGQLHGARPLGTGERWNLVVWLRASAVRNSLCPMCCREPDLVDDEGFGDGFTREEPATVDVCALT |
Proteomic databases
PTM databases
Expression
Interaction
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | Q6N063-2 | CASP6 P55212 | 3 | EBI-22006224, EBI-718729 | |
BINARY | Q6N063-2 | COQ8A Q8NI60 | 3 | EBI-22006224, EBI-745535 | |
BINARY | Q6N063-2 | HIP1 O00291 | 3 | EBI-22006224, EBI-473886 | |
BINARY | Q6N063-2 | LAMP2 P13473-2 | 3 | EBI-22006224, EBI-21591415 | |
BINARY | Q6N063-2 | PRPF40A O75400-2 | 3 | EBI-22006224, EBI-5280197 | |
BINARY | Q6N063-2 | RAN P62826 | 3 | EBI-22006224, EBI-286642 |
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 215-309 | Fe2OG dioxygenase | ||||
Sequence: DSHRAFVVKYAPGQDLELGCHYDNAELTLNVALGKVFTGGALYFGGLFQAPTALTEPLEVEHVVGQGVLHRGGQLHGARPLGTGERWNLVVWLRA |
Sequence similarities
Belongs to the OGFOD2 family.
Phylogenomic databases
Family and domain databases
Sequence & Isoforms
- Sequence statusComplete
This entry describes 4 isoforms produced by Alternative splicing.
Q6N063-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length350
- Mass (Da)38,996
- Last updated2007-05-29 v2
- Checksum651D0F07A32EBB66
Q6N063-2
- Name2
Q6N063-3
- Name3
Q6N063-4
- Name4
- Differences from canonical
- 1-164: Missing
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Sequence caution
Features
Showing features for alternative sequence, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_025856 | 1-60 | in isoform 2 | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_025855 | 1-164 | in isoform 4 | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_025857 | 61-62 | in isoform 2 | |||
Sequence: LA → MV | ||||||
Alternative sequence | VSP_025858 | 64 | in isoform 3 | |||
Sequence: L → WPQEDGRPHLVTTLCHPSLSRRWSGGSGWGRSQQLGKPSSRVPTTRHGLRSTTHCRMQLWPPSSWP | ||||||
Alternative sequence | VSP_025859 | 65-350 | in isoform 3 | |||
Sequence: Missing | ||||||
Sequence conflict | 244 | in Ref. 2; CAE45807 | ||||
Sequence: N → S | ||||||
Sequence conflict | 311 | in Ref. 5; AAH98119/AAI01941 | ||||
Sequence: A → T |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AK023553 EMBL· GenBank· DDBJ | BAB14610.1 EMBL· GenBank· DDBJ | mRNA | ||
AK094820 EMBL· GenBank· DDBJ | BAG52936.1 EMBL· GenBank· DDBJ | mRNA | ||
CR457316 EMBL· GenBank· DDBJ | CAG33597.1 EMBL· GenBank· DDBJ | mRNA | ||
BX640675 EMBL· GenBank· DDBJ | CAE45807.1 EMBL· GenBank· DDBJ | mRNA | ||
BX640734 EMBL· GenBank· DDBJ | CAE45849.1 EMBL· GenBank· DDBJ | mRNA | Sequence problems. | |
CH471054 EMBL· GenBank· DDBJ | EAW98364.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC098119 EMBL· GenBank· DDBJ | AAH98119.1 EMBL· GenBank· DDBJ | mRNA | ||
BC098293 EMBL· GenBank· DDBJ | AAH98293.1 EMBL· GenBank· DDBJ | mRNA | ||
BC101940 EMBL· GenBank· DDBJ | AAI01941.1 EMBL· GenBank· DDBJ | mRNA | ||
BC105637 EMBL· GenBank· DDBJ | AAI05638.1 EMBL· GenBank· DDBJ | mRNA |