Q6MZW7 · Q6MZW7_HUMAN
- ProteinChloride anion exchanger
- GeneDKFZp686P10213
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids651 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score2/5
Function
function
Mediates chloride-bicarbonate exchange with a chloride bicarbonate stoichiometry of 2:1 in the intestinal epithelia. Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | membrane | |
Molecular Function | antiporter activity | |
Molecular Function | monoatomic anion transmembrane transporter activity | |
Molecular Function | secondary active sulfate transmembrane transporter activity |
Keywords
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameChloride anion exchanger
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ6MZW7
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 42-63 | Helical | ||||
Sequence: IVSGISTGIVAVLQGLAFALLV | ||||||
Transmembrane | 69-85 | Helical | ||||
Sequence: YGLYASFFPAIIYLFFG | ||||||
Transmembrane | 141-161 | Helical | ||||
Sequence: VAAAASVTVLSGIIQLAFGIL | ||||||
Transmembrane | 173-195 | Helical | ||||
Sequence: SLISGFTTAAAVHVLVSQLKFIF | ||||||
Transmembrane | 222-240 | Helical | ||||
Sequence: TNIADLVTALIVLLVVSIV | ||||||
Transmembrane | 308-328 | Helical | ||||
Sequence: CFGIAMVAFAVAFSVASVYSL | ||||||
Transmembrane | 340-357 | Helical | ||||
Sequence: LIALGLGNIVCGVFRGFA | ||||||
Transmembrane | 377-398 | Helical | ||||
Sequence: IAGLIGAIIVLIVVLAIGFLLA | ||||||
Transmembrane | 435-466 | Helical | ||||
Sequence: LIWIMTFIFTIVLGLGLGLAASVAFQLLTIVF |
Keywords
- Cellular component
PTM/Processing
Proteomic databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 490-607 | STAS | ||||
Sequence: DYYDMYEPEGVKIFRCPSPIYFANIGFFRRKLIDAVGFSPLRILRKRNKALRKIRKLQKQGLLQVTPILQEFIRIKVDVYIVGTDDDFIEKLNRYEFFDGEVKSSIFFLTIHDAVLHI |
Sequence similarities
Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length651
- Mass (Da)71,917
- Last updated2004-07-05 v1
- Checksum311F2C9D6B3FF0A8