Q6MT29 · Q6MT29_MYCMS

Function

function

This protein specifically catalyzes the removal of signal peptides from prolipoproteins.

Catalytic activity

  • Release of signal peptides from bacterial membrane prolipoproteins. Hydrolyzes -Xaa-Yaa-Zaa-|-(S,diacylglyceryl)Cys-, in which Xaa is hydrophobic (preferably Leu), and Yaa (Ala or Ser) and Zaa (Gly or Ala) have small, neutral side chains.
    EC:3.4.23.36 (UniProtKB | ENZYME | Rhea)

Pathway

Protein modification; lipoprotein biosynthesis (signal peptide cleavage).

Features

Showing features for active site.

120220406080100120140160180200
TypeIDPosition(s)Description
Active site142
Active site162

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular Functionaspartic-type endopeptidase activity
Biological Processproteolysis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Lipoprotein signal peptidase
  • EC number
  • Alternative names
    • Prolipoprotein signal peptidase
    • Signal peptidase II
      (SPase II
      )

Gene names

    • Name
      lsp
    • Synonyms
      lspA
    • Ordered locus names
      MSC_0584

Organism names

Accessions

  • Primary accession
    Q6MT29

Proteomes

Subcellular Location

Cell membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane20-38Helical
Transmembrane82-103Helical
Transmembrane108-129Helical
Transmembrane163-184Helical

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the peptidase A8 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    202
  • Mass (Da)
    23,493
  • Last updated
    2004-07-05 v1
  • Checksum
    5F9F8256DF4223F1
MWIKDKLVEAKVFLKNHNYLWKFKLIVCLPIFISLISFDWISKAIVVSHMKLGETKTFISGFLNFQYVINLGMAYGRLQDKAYLVIIFATIFSLFLTTIFIFLNNKKWLIVLIIILAGSWGNLLARLWAPGNENNVYFGVVDFLTWDFSLLNSRDYVFNLADLYVNIAIGLTILFTIIELVLYIKSKIKTKKEKIENEQNNS

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BX293980
EMBL· GenBank· DDBJ
CAE77207.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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