Q6MSC7 · PURA_MYCMS

Function

function

Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.

Pathway

Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site16-22GTP (UniProtKB | ChEBI)
Active site17Proton acceptor
Binding site17Mg2+ (UniProtKB | ChEBI)
Binding site17-20IMP (UniProtKB | ChEBI); ligand shared between dimeric partners; in other chain
Binding site42-45IMP (UniProtKB | ChEBI); ligand shared between dimeric partners; in other chain
Binding site44Mg2+ (UniProtKB | ChEBI)
Binding site44-46GTP (UniProtKB | ChEBI)
Active site45Proton donor
Binding site132IMP (UniProtKB | ChEBI); ligand shared between dimeric partners; in other chain
Binding site146IMP (UniProtKB | ChEBI); ligand shared between dimeric partners
Binding site226IMP (UniProtKB | ChEBI); ligand shared between dimeric partners; in other chain
Binding site241IMP (UniProtKB | ChEBI); ligand shared between dimeric partners; in other chain
Binding site301-307substrate
Binding site305IMP (UniProtKB | ChEBI); ligand shared between dimeric partners; in other chain
Binding site307GTP (UniProtKB | ChEBI)
Binding site333-335GTP (UniProtKB | ChEBI)
Binding site415-417GTP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionadenylosuccinate synthase activity
Molecular FunctionGTP binding
Molecular Functionmagnesium ion binding
Biological Process'de novo' AMP biosynthetic process
Biological ProcessIMP metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Adenylosuccinate synthetase
  • EC number
  • Short names
    AMPSase
    ; AdSS
  • Alternative names
    • IMP--aspartate ligase

Gene names

    • Name
      purA
    • Ordered locus names
      MSC_0850

Organism names

Accessions

  • Primary accession
    Q6MSC7

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002242951-432Adenylosuccinate synthetase

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the adenylosuccinate synthetase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    432
  • Mass (Da)
    49,098
  • Last updated
    2004-07-05 v1
  • Checksum
    3DCC6894937C5A01
MKNNYKSLVIVGSQWGDEGKGKITDYFSQKADVVVRFAGGDNAGHMIEFNNKRHKVTIIPSGVFNPKVKNIIGNGTVINLKSLVNEIKRLNESNISTDNVFVSDRAHLIFDWHALIDQLQEENRKENKIGTTKRGIGPTYADKAARYGIRICDFQNPNFKEILKENLDYHNQIITKVYNHEPLDFDVIYNESMTNYQFIKNNIIDSGYEVSNLINENKFVLFEGAQGVLLDIDHGTYPFVTSSNCSANNASIGTGIHNKQINKVLGIVKAYNTRVGSGAMVSEIKTELAHKLRERGREYGLNTGRPRRIGWLDLVALKYAIRVGGIDQLFLTLFDVLDTETKIKICTHYKLDGKIIDWFPASDYELKRCEPVYEELDGWNQDITKVTSFEELPINAQKYIKRIEEIVKVPFLGFSVGSDRKQTILIKGEFDD

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BX293980
EMBL· GenBank· DDBJ
CAE77463.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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