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Q6M931 · Q6M931_NEUCS

  • Protein
    DNA replication ATP-dependent helicase/nuclease
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Key enzyme involved in DNA replication and DNA repair. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double-strand break (DSB) repair by mediating the cleavage of 5'-ssDNA.

Catalytic activity

Cofactor

[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentchromosome
Cellular Componentmitochondrion
Cellular Componentnucleus
Molecular Function4 iron, 4 sulfur cluster binding
Molecular Function5'-flap endonuclease activity
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular FunctionDNA binding
Molecular Functionmetal ion binding
Molecular Functionsingle-stranded DNA helicase activity
Biological ProcessDNA repair
Biological ProcessDNA replication, Okazaki fragment processing
Biological Processreplication fork reversal

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    DNA replication ATP-dependent helicase/nuclease
  • EC number

Gene names

    • ORF names
      H4H7.170

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Sordariomycetes > Sordariomycetidae > Sordariales > Sordariaceae > Neurospora

Accessions

  • Primary accession
    Q6M931

Organism-specific databases

Subcellular Location

Mitochondrion
Nucleus
Chromosome

Keywords

Family & Domains

Features

Showing features for region, compositional bias, domain.

Type
IDPosition(s)Description
Region1-360Disordered
Compositional bias19-59Polar residues
Compositional bias89-136Basic and acidic residues
Compositional bias160-174Polar residues
Compositional bias198-240Polar residues
Compositional bias251-273Basic and acidic residues
Compositional bias274-327Polar residues
Compositional bias328-353Basic and acidic residues
Region376-410Disordered
Region422-473Disordered
Compositional bias435-451Basic residues
Domain545-747DNA replication factor Dna2 N-terminal
Domain766-867DUF83
Domain928-1020DNA2 rift barrel
Domain1122-1208DNA2/NAM7 helicase helicase
Domain1222-1290DNA2/NAM7 helicase helicase
Domain1298-1552DNA2/NAM7 helicase-like C-terminal
Region1558-1590Disordered
Region1628-1709Disordered
Compositional bias1673-1692Polar residues

Sequence similarities

Belongs to the DNA2/NAM7 helicase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,735
  • Mass (Da)
    191,808
  • Last updated
    2004-07-05 v1
  • MD5 Checksum
    13B660F5928038CCFD8EBE177360DB6A
MPLKKSYSDAYAQPPKRGGWQRTRSNPPNKGPLQSLAPVSESSKNKLQAFRSDDTSSKPPPKSARPVKAAIDELQKENINTTKSIPRKRPLPDSNDDEPSSDAKTPADRHSWKDLFGVPEVITEEEDGEKSPGDRVDWRSGVPLQLPASPMIPKNGRRRAKSSSPASSPATKLTTPHVALKRFAGASKTPHADPASDLWSRFSSNGNDTSPSNHKNPLFAQLMASSSPRPQSSDRSLRKSVSCGSAWPKRRRTLCPEEQNRIVSQDTPRKKKSSLLSELLQSVDGEIDSSKTPSNAPAQQKKSPSPMKKSPSKRKITPQTVPDQNSSPSRKKAERQTTETDASKQPEKASSDYGDDDFDFDESTLLELDASILGQGDGSTLIASDAVSPAPRESSKTLVDNDEFGDLDDDIFDGVEDLVAQVESATQKPAQRLSPRKRPSPKKRLSPRKRQSPKKLPQQVAGDEDDEFGDDFGNDFDFDAVEMAATQRASHAQDVSSHPSQKPRAIQRYLVTNVLESSYTDDRGRESPEKVESPFRQYILIVQADRTNSVRTIHLRGDWFDTPASVSAYVHIIGQFEDQGKCVLDNNQNMLILHPDQLISSTVVADSFSCMRRAVLQDRVKATSDLTPALVYGTILHEIFQEALVANKWDPAFLTNVINKTLEKHLEDLYILKVSMDDAKSHVQSKMPELRSWAQLFVTSQPKPDAIVQGRNGDKATMCVSKLLDVEEHVWSPMYGLKGNIDATVQVTMRDPPARGSSSKAPTTKTLTVPFEVKTGKNVNSNHQAQTALYNLLLSDRYDIEIVYGILYYMETSQTLRIPAVRHEIRHMIMQRNQLACYIRERSVQLPPMKKNKNACGRCYAQTTCFIYHKLADDGDGETSAMNEKFDEVVHHLSPTHKAFFLKWEELLTKEEKESQKLRRELWTMISTEREKVGRCFANVIIEEGSAYENHQQMGKTNRFAYTFIKEKPAPGFSFLDSQLTVGEPIVISDEQGHFALALGYVTSVRKTRIAVAVDRRLHNARVRQPGFDEADNQTFASIMQVPGSGGNAPEDREAGPVRYRLDKDEFSNGMATVRNNLVQIMADGVLGSRQIRSLVVDLEAPRFKAVPTQYILPSTASGQGLNVDQKAAVEKVMSAQDYALVLGMPGTGKTTTIAHIIRALVAQKKTVLLTSYTHTAVDNILLKLKDDGIPILRLGPPVKVHPEVPSFATLAGVPKTSFSEIHEAWNDTPIVATTCLGINHPVFAERIFDYCIVDEASQITLPICLGPIRMARKFVLVGDHNQLPPLVQNEEARLGGLDVSLFKLLSEKHPQSVVNLEHQYRMCEDIMTLSNTLIYNGRLKCGTEALRTTSLEIPDMDALATKHFDADSFLAHSQQHPLKEGDKLSFCPSPTPTTCWLRDLLDPSARVRFINTDSLLPHSREEKSTRGQRIVNPLESRIVCQLVDSLLTVGVPASEIGVMTHYRSQLALLKHNMKNTLGGSAGAIRAGVKVAAEEIEMHTADRFQGRDKSVVVLSLVRSNEGCSIGELLKDWRRINVAFTRAKTKLLVVGSRETLRGASSSVAGSPTAIASPELGETGDDQGEGQGEPEGGEMLARFVRMMEDRNWVYELRPGALEGHRFADANAASTAADALSPRKPNPIFKPVSPRKGSALSPSKRANAKLAGKGYKVQSKLQFGTPSQGKENVGSQSLKSPKKGIVGRGKHNPKRIGISERAIMKGRPIMRDIMNEITDGRF

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias19-59Polar residues
Compositional bias89-136Basic and acidic residues
Compositional bias160-174Polar residues
Compositional bias198-240Polar residues
Compositional bias251-273Basic and acidic residues
Compositional bias274-327Polar residues
Compositional bias328-353Basic and acidic residues
Compositional bias435-451Basic residues
Compositional bias1673-1692Polar residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BX908811
EMBL· GenBank· DDBJ
CAF06129.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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