Q6M931 · Q6M931_NEUCS
- ProteinDNA replication ATP-dependent helicase/nuclease
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1735 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Key enzyme involved in DNA replication and DNA repair. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double-strand break (DSB) repair by mediating the cleavage of 5'-ssDNA.
Catalytic activity
- ATP + H2O = ADP + phosphate + H+
Cofactor
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | chromosome | |
Cellular Component | mitochondrion | |
Cellular Component | nucleus | |
Molecular Function | 4 iron, 4 sulfur cluster binding | |
Molecular Function | 5'-flap endonuclease activity | |
Molecular Function | ATP binding | |
Molecular Function | ATP hydrolysis activity | |
Molecular Function | DNA binding | |
Molecular Function | metal ion binding | |
Molecular Function | single-stranded DNA helicase activity | |
Biological Process | DNA repair | |
Biological Process | DNA replication, Okazaki fragment processing | |
Biological Process | replication fork reversal |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDNA replication ATP-dependent helicase/nuclease
- EC number
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Sordariomycetes > Sordariomycetidae > Sordariales > Sordariaceae > Neurospora
Accessions
- Primary accessionQ6M931
Organism-specific databases
Subcellular Location
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 1-360 | Disordered | |||
Compositional bias | 19-59 | Polar residues | |||
Compositional bias | 89-136 | Basic and acidic residues | |||
Compositional bias | 160-174 | Polar residues | |||
Compositional bias | 198-240 | Polar residues | |||
Compositional bias | 251-273 | Basic and acidic residues | |||
Compositional bias | 274-327 | Polar residues | |||
Compositional bias | 328-353 | Basic and acidic residues | |||
Region | 376-410 | Disordered | |||
Region | 422-473 | Disordered | |||
Compositional bias | 435-451 | Basic residues | |||
Domain | 545-747 | DNA replication factor Dna2 N-terminal | |||
Domain | 766-867 | DUF83 | |||
Domain | 928-1020 | DNA2 rift barrel | |||
Domain | 1122-1208 | DNA2/NAM7 helicase helicase | |||
Domain | 1222-1290 | DNA2/NAM7 helicase helicase | |||
Domain | 1298-1552 | DNA2/NAM7 helicase-like C-terminal | |||
Region | 1558-1590 | Disordered | |||
Region | 1628-1709 | Disordered | |||
Compositional bias | 1673-1692 | Polar residues | |||
Sequence similarities
Belongs to the DNA2/NAM7 helicase family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,735
- Mass (Da)191,808
- Last updated2004-07-05 v1
- MD5 Checksum13B660F5928038CCFD8EBE177360DB6A
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 19-59 | Polar residues | |||
Compositional bias | 89-136 | Basic and acidic residues | |||
Compositional bias | 160-174 | Polar residues | |||
Compositional bias | 198-240 | Polar residues | |||
Compositional bias | 251-273 | Basic and acidic residues | |||
Compositional bias | 274-327 | Polar residues | |||
Compositional bias | 328-353 | Basic and acidic residues | |||
Compositional bias | 435-451 | Basic residues | |||
Compositional bias | 1673-1692 | Polar residues | |||
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BX908811 EMBL· GenBank· DDBJ | CAF06129.1 EMBL· GenBank· DDBJ | Genomic DNA |