Q6LTK3 · FADJ_PHOPR
- ProteinFatty acid oxidation complex subunit alpha
- GenefadJ
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids715 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities.
Catalytic activity
- a (3S)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O
Pathway
Lipid metabolism; fatty acid beta-oxidation.
Features
Showing features for site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Site | 125 | Important for catalytic activity | |||
Site | 147 | Important for catalytic activity | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | 3-hydroxyacyl-CoA dehydrogenase activity | |
Molecular Function | 3-hydroxybutyryl-CoA epimerase activity | |
Molecular Function | enoyl-CoA hydratase activity | |
Molecular Function | NAD+ binding | |
Biological Process | fatty acid beta-oxidation |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameFatty acid oxidation complex subunit alpha
Including 2 domains:
- Recommended nameEnoyl-CoA hydratase/3-hydroxybutyryl-CoA epimerase
- EC number
- Recommended name3-hydroxyacyl-CoA dehydrogenase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Vibrionales > Vibrionaceae > Photobacterium
Accessions
- Primary accessionQ6LTK3
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000109302 | 1-715 | Fatty acid oxidation complex subunit alpha | ||
Interaction
Subunit
Heterotetramer of two alpha chains (FadJ) and two beta chains (FadI).
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 8-197 | Enoyl-CoA hydratase | |||
Region | 313-715 | 3-hydroxyacyl-CoA dehydrogenase | |||
Sequence similarities
In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.
In the central section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length715
- Mass (Da)77,342
- Last updated2004-07-05 v1
- MD5 Checksum0609553F35E3EC7A79A4BEBB100EAE57
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CR378666 EMBL· GenBank· DDBJ | CAG19373.1 EMBL· GenBank· DDBJ | Genomic DNA |