Deficiency of retinoblastoma protein leads to inappropriate S-phase entry, activation of E2F-responsive genes, and apoptosis.
- AnnotationE2F target genes display elevated levels in Rb-/- MEFs. Absence of functional Rb is sufficient for S-phase entry under growth-limiting conditions indicating that the E2F complexes containing Rb protein may be rate limiting for the G1/S transition.
- CategoryFunction
- SourceGeneRif: 5925