Relationship of Muscle Apolipoprotein E Expression with Markers of Cellular Stress Metabolism and Blood Biomarkers in Cognitively Healthy and Impaired Older Adults.
APOE is specifically repressed in Alzheimer's disease oligodendrocyte progenitor cells and astrocyte subpopulations and upregulated in an Alzheimer's disease-specific microglial subopulation.
In het mice RIF had no effect on plasma lipids composition CYP27A1 activity and atherosclerotic plaque development despite a reduction in cholesterol absorption. In conclusion the antiatherogenic effect of Cyp3a11 induction by RIF was also dependent on Cyp27a1 expression.
Blood samples were obtained from 30 patients with relapsing-remitting MS (RRMS) along with 30 age and sex-matched healthy individuals then peripheral blood mononuclear cells (PBMCs) were isolated. The quantitative Real-Time PCR was carried out for Klotho mRNA derived from PBMCs. The results showed that klotho gene expression in the PBMCs of patients with RRMS is nearly 2.5-fold less than healthy individuals.
People with an APOEvarepsilon32 genotype have a reduced risk of Alzheimer's disease. It may be relevant that they have a higher level of post-synaptic proteins in the hippocampus even in earlier adulthood.
ApoE mRNA levels were not affected by complement challenge. ApoE was frequently colocalized with MAC in complement-treated cells and drusen from human eyes. ApoE was released into complement-treated conditioned media after a single complement challenge and accumulated on ECM after repetitive complement challenge.
This study found that APOE3 and APOE4 targeted replacement mice demonstrate similar cognitive impairment following moderate TBI with differences reflecting the preexisting deficits in APOE4 mice at baseline.
selective degeneration of dopaminergic terminals throughout the striatum in individuals with Lewy body disease and serotonergic degeneration in human ventromedial caudate nucleus from individuals with an APOE epsilon4 allele.
Results strongly suggests a role for human ApoE4 in cerebral ceramide and fatty acid (FA) homeostasis. The absence of mouse apoE resulted in low cerebral ceramide levels which was not restored by human ApoE4. The APOE genotype affected brain FA profile when mice were fed a high fat/high cholesterol diet.
APOE the gene related to thrombogenesis was differentially expressed between the left atrium and right atrium in Sinus rhythm and Atrial fibrillation. Therefore the changes in the expression of these genes were likely involved in the pathophysiology of AF-related thrombus formation.
C2238/alphaANP downregulates ApoE in vascular smooth muscle cells through type C natriuretic peptide receptor-dependent activation of Egr-1 and the consequent upregulation of miR199a.
Depletion of endogenous APOE in human adipocytes severely impairs lipid accumulation which is associated with an inability to initiate differentiation.
Studied and id'd proteins differentially abundant in current smokers vs. ex-smokers & never smokers; results demonstrated an increase of APOE in current smokers as compared to both never and ex-smokers.
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