Q6L743 · DOIAD_STRKN

  • Protein
    2-deoxy-scyllo-inosamine dehydrogenase
  • Gene
    kanE
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the oxidation of 2-deoxy-scyllo-inosamine (DOIA) with NAD+ or NADP+, forming 3-amino-2,3-dideoxy-scyllo-inosose (amino-DOI).

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 2 Zn2+ ions per subunit.

Pathway

Metabolic intermediate biosynthesis; 2-deoxystreptamine biosynthesis; 2-deoxystreptamine from D-glucose 6-phosphate: step 3/4.
Antibiotic biosynthesis; kanamycin biosynthesis.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site37Zn2+ 1 (UniProtKB | ChEBI); catalytic
Binding site59Zn2+ 1 (UniProtKB | ChEBI); catalytic
Binding site91Zn2+ 2 (UniProtKB | ChEBI)
Binding site94Zn2+ 2 (UniProtKB | ChEBI)
Binding site97Zn2+ 2 (UniProtKB | ChEBI)
Binding site105Zn2+ 2 (UniProtKB | ChEBI)
Binding site146Zn2+ 1 (UniProtKB | ChEBI); catalytic

GO annotations

AspectTerm
Molecular Functionmetal ion binding
Molecular Functionoxidoreductase activity
Biological Processantibiotic biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    2-deoxy-scyllo-inosamine dehydrogenase
  • EC number
  • Short names
    DOIA dehydrogenase

Gene names

    • Name
      kanE
    • Synonyms
      kanK

Organism names

  • Taxonomic identifier
  • Strains
    • ATCC 12853 / DSM 40500 / NBRC 13414 / NCIMB 9343 / NRRL B-2535 / VKM Ac-837
    • 21-18
  • Taxonomic lineage
    Bacteria > Actinomycetota > Actinomycetes > Kitasatosporales > Streptomycetaceae > Streptomyces

Accessions

  • Primary accession
    Q6L743

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002340441-3432-deoxy-scyllo-inosamine dehydrogenase

Structure

Family & Domains

Sequence similarities

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    343
  • Mass (Da)
    35,936
  • Last updated
    2004-07-05 v1
  • Checksum
    A61AFA1521BAEFB8
MKALVFHSPEKATFEQRDVPTPRPGEALVHIAYNSICGSDLSLYRGVWHGFGYPVVPGHEWSGTVVEINGANGHDQSLVGKNVVGDLTCACGNCAACGRGTPVLCENLQELGFTKDGACAEYMTIPVDNLRPLPDALSLRSACQVEPLAVALNAVSIAGVAPGDRVAVMGAGGIGLMLMQVARHLGGEVTVVSEPVAERRAVAGQLGATELCSAEPGQLAELVARRPELTPDVVLEASGYPAALQEAIEVVRPGGRIGLIGYRVEETGPMSPQHIAVKALTLRGSLGPGGRFDDAVELLAKGDDIAVEPLLSHEFGLADYATALDLALSRTNGNVRSFFNLRD

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AJ582817
EMBL· GenBank· DDBJ
CAF60530.1
EMBL· GenBank· DDBJ
Genomic DNA
AB164642
EMBL· GenBank· DDBJ
BAD20754.1
EMBL· GenBank· DDBJ
Genomic DNA
AJ628422
EMBL· GenBank· DDBJ
CAF31584.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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