Q6L739 · GLDSA_STRKN
- ProteinL-glutamine:2-deoxy-scyllo-inosose aminotransferase
- GenekanB
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids427 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
Catalyzes the PLP-dependent transamination of 2-deoxy-scyllo-inosose (2-DOI) to form 2-deoxy-scyllo-inosamine (2-DOIA) using L-glutamine as the amino donor. Also catalyzes the transamination of 3-amino-2,3-dideoxy-scyllo-inosose (keto-2-DOIA) into 2-deoxystreptamine (2-DOS).
Catalytic activity
- 2-deoxy-L-scyllo-inosose + L-glutamine = 2-deoxy-scyllo-inosamine + 2-oxoglutaramate
Cofactor
Pathway
Metabolic intermediate biosynthesis; 2-deoxystreptamine biosynthesis; 2-deoxystreptamine from D-glucose 6-phosphate: step 2/4.
Antibiotic biosynthesis; kanamycin biosynthesis.
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | pyridoxal phosphate binding | |
Molecular Function | transaminase activity | |
Biological Process | antibiotic biosynthetic process | |
Biological Process | polysaccharide biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameL-glutamine:2-deoxy-scyllo-inosose aminotransferase
- EC number
- Short namesL-glutamine:DOI aminotransferase
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Kitasatosporales > Streptomycetaceae > Streptomyces
Accessions
- Primary accessionQ6L739
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000233019 | 1-427 | L-glutamine:2-deoxy-scyllo-inosose aminotransferase | |||
Sequence: MPLQSSRLAVDNGTPVRGKPWPVWPQPTDGTLDALSRVLRSGRWAISGPYRGVESAERRFARRFADYHRIAHCVPASSGTASLMLALEACGVGAGDEVILPGVTWVASASTVVGVNAVPVFADIDPDTLCLDPDAVEAAITPATKAIVVVHLYAAVADLTRLKEVADRHGIVLIEDCAQAHGAEFEGHKVGTFGAVGTFSMQQSKVLTSGEGGAAITADPVLARRMEHLRADGRCYRDQAPPSGHMELVETGELMGSNRCISEFQAAVLTEQLGELDRFNALRRHNAELLDALLTDVGYRPQRSTPGTTARTYYTYVAELPDAELPGADITKVTEALTAELGFPVAPAYSPLNANPLYDPASRSRFALGPQHEKLIDPARFVLPVSGRLTRRLVTFHHAALLGDESDMRDIAEAFTKVLQHRAVLAA | ||||||
Modified residue | 205 | N6-(pyridoxal phosphate)lysine | ||||
Sequence: K |
Structure
Family & Domains
Features
Showing features for region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-20 | Disordered | ||||
Sequence: MPLQSSRLAVDNGTPVRGKP |
Sequence similarities
Belongs to the DegT/DnrJ/EryC1 family. L-glutamine:2-deoxy-scyllo-inosose/scyllo-inosose aminotransferase subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length427
- Mass (Da)45,870
- Last updated2004-07-05 v1
- ChecksumF2F738CC5AD4C7B2
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AJ582817 EMBL· GenBank· DDBJ | CAE46938.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AB164642 EMBL· GenBank· DDBJ | BAD20758.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AJ628422 EMBL· GenBank· DDBJ | CAF31588.1 EMBL· GenBank· DDBJ | Genomic DNA |