Q6KHA4 · FTSH_MYCM1
- ProteinATP-dependent zinc metalloprotease FtsH
- GeneftsH
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids707 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.
Cofactor
Note: Binds 1 zinc ion per subunit.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 246-253 | ATP (UniProtKB | ChEBI) | |||
Binding site | 468 | Zn2+ (UniProtKB | ChEBI); catalytic | |||
Active site | 469 | ||||
Binding site | 472 | Zn2+ (UniProtKB | ChEBI); catalytic | |||
Binding site | 546 | Zn2+ (UniProtKB | ChEBI); catalytic | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | ATP binding | |
Molecular Function | ATP hydrolysis activity | |
Molecular Function | ATP-dependent peptidase activity | |
Molecular Function | metalloendopeptidase activity | |
Molecular Function | zinc ion binding | |
Biological Process | protein catabolic process | |
Biological Process | proteolysis |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameATP-dependent zinc metalloprotease FtsH
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Mycoplasmatota > Mycoplasmoidales > Metamycoplasmataceae > Mesomycoplasma
Accessions
- Primary accessionQ6KHA4
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Topological domain | 1-25 | Cytoplasmic | |||
Transmembrane | 26-46 | Helical | |||
Topological domain | 47-128 | Extracellular | |||
Transmembrane | 129-149 | Helical | |||
Topological domain | 150-707 | Cytoplasmic | |||
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000400360 | 1-707 | ATP-dependent zinc metalloprotease FtsH | ||
Interaction
Structure
Family & Domains
Sequence
- Sequence statusComplete
- Length707
- Mass (Da)77,794
- Last updated2004-07-05 v1
- Checksum70F1D43AD92E5D0E
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AE017308 EMBL· GenBank· DDBJ | AAT28026.1 EMBL· GenBank· DDBJ | Genomic DNA |