Q6KHA4 · FTSH_MYCM1

Function

function

Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Features

Showing features for binding site, active site.

170750100150200250300350400450500550600650700
Type
IDPosition(s)Description
Binding site246-253ATP (UniProtKB | ChEBI)
Binding site468Zn2+ (UniProtKB | ChEBI); catalytic
Active site469
Binding site472Zn2+ (UniProtKB | ChEBI); catalytic
Binding site546Zn2+ (UniProtKB | ChEBI); catalytic

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular FunctionATP-dependent peptidase activity
Molecular Functionmetalloendopeptidase activity
Molecular Functionzinc ion binding
Biological Processprotein catabolic process
Biological Processproteolysis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    ATP-dependent zinc metalloprotease FtsH
  • EC number

Gene names

    • Name
      ftsH
    • Ordered locus names
      MMOB5400

Organism names

Accessions

  • Primary accession
    Q6KHA4

Proteomes

Subcellular Location

Cell membrane
; Multi-pass membrane protein

Features

Showing features for topological domain, transmembrane.

Type
IDPosition(s)Description
Topological domain1-25Cytoplasmic
Transmembrane26-46Helical
Topological domain47-128Extracellular
Transmembrane129-149Helical
Topological domain150-707Cytoplasmic

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004003601-707ATP-dependent zinc metalloprotease FtsH

Interaction

Subunit

Homohexamer.

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

In the central section; belongs to the AAA ATPase family.
In the C-terminal section; belongs to the peptidase M41 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    707
  • Mass (Da)
    77,794
  • Last updated
    2004-07-05 v1
  • Checksum
    70F1D43AD92E5D0E
MSELDNKKDKSKDSNKKPKKPGAFSIGNIIIFVIVALLLIWVVFAFLPNNPGTNKSFDGFLKDLQDAARLGDDTIFFRNISFDVVLSRFNVTFVNGATTSSYFVNYPSSVAFQNLQIPGTTFTGLELATLAIANTSASGIGTLNFSGLVTPTNQALAILLSLIPTFLFVGIIFFVYKMQSKANGGMGGFNPGKNQAERIYTKIKFSDIAGNEEVKEEVAELVDYLKNPKKYSASGARIPRGILLGGPPGTGKTLLAKATAGEANVPFYFISGSNFVELFVGVGAKRVRELFKEARKSSPAIIFIDELDAVGRSRGAGIGGGNDEREQTLNQLLVEMDGMTENSGLLVMAATNRTDVLDPALLRPGRFDRTVTVGLPNVKDREAILKLHAKGKRISSEVSFQQLAKRTPGYSGAQLENVINEASLLSVREDTKIITLEQFDEAIDRVMSGPAKKSRVITKEELTAVAYHEAGHAVVGTQLRKGVKVQKITIIPRGSAGGYNLMIPEEEKYNSSKSELIAMITSFMGGRAAEQIIYGEKEVSTGARDDIKKATSIARKMVTEWGMSDLGPIMYEEDTSNPFLGRDYTKNQLFSDHIAREIDTEVRKIILTAEQKAIEVIQENREMLELIKEALLENETIVDEEIQYIAKNLKLPSMRTKAKSENVNQIRNVDELVKEVKDQTLIIKDKNDKKIKDSENNIKTDESLDIK

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AE017308
EMBL· GenBank· DDBJ
AAT28026.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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