Q6KAU4 · MB12B_MOUSE
- ProteinMultivesicular body subunit 12B
- GeneMvb12b
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids317 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (By similarity).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | early endosome | |
Cellular Component | ESCRT I complex | |
Cellular Component | late endosome | |
Cellular Component | late endosome membrane | |
Cellular Component | nucleus | |
Cellular Component | plasma membrane | |
Molecular Function | lipid binding | |
Biological Process | protein transport | |
Biological Process | regulation of epidermal growth factor receptor signaling pathway | |
Biological Process | viral budding | |
Biological Process | virus maturation |
Keywords
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameMultivesicular body subunit 12B
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ6KAU4
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Late endosome membrane ; Peripheral membrane protein
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000249075 | 1-317 | Multivesicular body subunit 12B | |||
Sequence: MRSCFCVRRSRDPPPPQPPPPQRGTDQATMPEVKELSEALPETPMDPITGVGVVASRNRAPTGYDVVAQTADGVDADLWKDGLFKSKVTRYLCFTRSFSKENSHLGNVLVDMKLIDVKDTLPVGFIPIQETVDTQEVVFRKKRLCIKFIPRDSTEAAICDIRIMGRTKQAPPQYTFIGELNSMGIWYRMGRVPRNHDSSQPTTPSQSSASSTPAPNLPRHISLTLPATFRGRNNTSTDYEYQLSNLYAISAMDGVPFMISEKFSCIPESMQPFDLLGITIKSLAEIEKEYEYSFRTEQSAAARLPPSPTRCQQIPQS | ||||||
Modified residue | 99 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 120 | Phosphothreonine | ||||
Sequence: T | ||||||
Modified residue | 202 | Phosphothreonine | ||||
Sequence: T | ||||||
Modified residue | 203 | Phosphothreonine | ||||
Sequence: T | ||||||
Modified residue | 222 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 307 | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Gene expression databases
Interaction
Subunit
Component of the ESCRT-I complex (endosomal sorting complex required for transport I) which consists of TSG101, VPS28, a VPS37 protein (VPS37A to -D) and MVB12A or MVB12B in a 1:1:1:1 stoichiometry. Interacts with TSG101; the association appears to be mediated by the TSG101-VPS37 binary subcomplex. Interacts with VPS28. Interacts with VPS37B; the association appears to be mediated by the TSG101-VPS37 binary subcomplex. Interacts with VPS37C; the association appears to be mediated by the TSG101-VPS37 binary subcomplex (By similarity).
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-49 | Disordered | ||||
Sequence: MRSCFCVRRSRDPPPPQPPPPQRGTDQATMPEVKELSEALPETPMDPIT | ||||||
Compositional bias | 11-25 | Pro residues | ||||
Sequence: RDPPPPQPPPPQRGT | ||||||
Domain | 45-191 | MABP | ||||
Sequence: MDPITGVGVVASRNRAPTGYDVVAQTADGVDADLWKDGLFKSKVTRYLCFTRSFSKENSHLGNVLVDMKLIDVKDTLPVGFIPIQETVDTQEVVFRKKRLCIKFIPRDSTEAAICDIRIMGRTKQAPPQYTFIGELNSMGIWYRMGR | ||||||
Region | 193-218 | Disordered | ||||
Sequence: PRNHDSSQPTTPSQSSASSTPAPNLP | ||||||
Compositional bias | 195-218 | Polar residues | ||||
Sequence: NHDSSQPTTPSQSSASSTPAPNLP | ||||||
Domain | 252-301 | UMA | ||||
Sequence: MDGVPFMISEKFSCIPESMQPFDLLGITIKSLAEIEKEYEYSFRTEQSAA | ||||||
Region | 297-317 | Disordered | ||||
Sequence: EQSAAARLPPSPTRCQQIPQS | ||||||
Compositional bias | 300-317 | Polar residues | ||||
Sequence: AAARLPPSPTRCQQIPQS |
Sequence similarities
Belongs to the MVB12 family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length317
- Mass (Da)35,411
- Last updated2006-09-05 v2
- Checksum0FF01346C82C7998
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A2ARF0 | A2ARF0_MOUSE | Mvb12b | 189 |
Sequence caution
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 11-25 | Pro residues | ||||
Sequence: RDPPPPQPPPPQRGT | ||||||
Compositional bias | 195-218 | Polar residues | ||||
Sequence: NHDSSQPTTPSQSSASSTPAPNLP | ||||||
Compositional bias | 300-317 | Polar residues | ||||
Sequence: AAARLPPSPTRCQQIPQS |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AK131113 EMBL· GenBank· DDBJ | BAD21363.1 EMBL· GenBank· DDBJ | mRNA | Different initiation | |
AL845360 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BX649361 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BC049129 EMBL· GenBank· DDBJ | AAH49129.2 EMBL· GenBank· DDBJ | mRNA | ||
BC059907 EMBL· GenBank· DDBJ | AAH59907.1 EMBL· GenBank· DDBJ | mRNA |