Q6JCQ9 · Q6JCQ9_TETAA

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Cellular Componentrespiratory chain complex IV
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processoxidative phosphorylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      COI

Encoded on

  • Mitochondrion

Organism names

Accessions

  • Primary accession
    Q6JCQ9

Subcellular Location

Membrane
; Multi-pass membrane protein
Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane12-35Helical
Transmembrane55-80Helical
Transmembrane100-126Helical
Transmembrane146-169Helical
Transmembrane181-209Helical
Transmembrane229-253Helical
Transmembrane265-289Helical
Transmembrane301-324Helical
Transmembrane336-358Helical
Transmembrane378-401Helical
Transmembrane413-432Helical
Transmembrane452-472Helical

Keywords

Interaction

Subunit

Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-511Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    512
  • Mass (Da)
    56,852
  • Last updated
    2004-10-11 v2
  • Checksum
    7D6ED15EF1103FE5
MYTWAFSTNHKDIGMLYFIFGIWSGLVGTSFSLLIRTELSNVGSFLLNDQLYNVLVTSHAFIMIFFMTMPLVIGGFGNWLVPLMVGSPDMAFPRMNNLSFWLLIPSLTMMVGSLIVGGGSGTGWTVYPPLSLNLSHSGCSVDMSILSLHIAGASSILGAINFIVTIFNMRLVGVGLDMISLFVWSVLITVFLLLISLPVLAGAITMLLFDRNFNSSFYDPLGGGDPILYQHLFWFFGHPEVYVLILPGFGIVSHLISNEAGKMEVFGGLGMIYAMVTIGVLGFIVWGHHMFTVGMDVDTRAYFTSATMVIAVPTGIKIFSWLATLGGMHFNWFSPLAFWFLGFLFLFTMGGLTGIVLGNSSVDVCLHDTYFVVAHFHYVLSMGIVFAIVGGFIFWFPLVTGVGMNCYMLISQFYLMFIGVNLTFFPQHFLGLGGMPRRYSDYGDCYLFWNKISSFGSIISLVSIIFFLFLILESFLSVRLVHFYLVVKSSLEWSLNKPSLSHSFGETGLVYF

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AY521262
EMBL· GenBank· DDBJ
AAT36457.2
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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