Q6J1T3 · MT_SCYTO

Function

function

Metallothioneins have a high content of cysteine residues that bind various heavy metals.

Features

Showing features for binding site.

1685101520253035404550556065MSDTKPCVCLDGSCSCENTCRCSDCRCPTSKAGRCQKSCCSCCPAGCTNCANGCVCKGKASDKCSCCS
TypeIDPosition(s)Description
Binding site7a divalent metal cation 1 (UniProtKB | ChEBI); in cluster B
Binding site9a divalent metal cation 1 (UniProtKB | ChEBI); in cluster B
Binding site9a divalent metal cation 2 (UniProtKB | ChEBI); in cluster B
Binding site14a divalent metal cation 2 (UniProtKB | ChEBI); in cluster B
Binding site16a divalent metal cation 2 (UniProtKB | ChEBI); in cluster B
Binding site16a divalent metal cation 3 (UniProtKB | ChEBI); in cluster B
Binding site20a divalent metal cation 3 (UniProtKB | ChEBI); in cluster B
Binding site22a divalent metal cation 1 (UniProtKB | ChEBI); in cluster B
Binding site25a divalent metal cation 1 (UniProtKB | ChEBI); in cluster B
Binding site25a divalent metal cation 3 (UniProtKB | ChEBI); in cluster B
Binding site27a divalent metal cation 2 (UniProtKB | ChEBI); in cluster B
Binding site35a divalent metal cation 3 (UniProtKB | ChEBI); in cluster B
Binding site39a divalent metal cation 4 (UniProtKB | ChEBI); in cluster A
Binding site40a divalent metal cation 4 (UniProtKB | ChEBI); in cluster A
Binding site40a divalent metal cation 5 (UniProtKB | ChEBI); in cluster A
Binding site42a divalent metal cation 5 (UniProtKB | ChEBI); in cluster A
Binding site43a divalent metal cation 5 (UniProtKB | ChEBI); in cluster A
Binding site43a divalent metal cation 6 (UniProtKB | ChEBI); in cluster A
Binding site47a divalent metal cation 6 (UniProtKB | ChEBI); in cluster A
Binding site50a divalent metal cation 4 (UniProtKB | ChEBI); in cluster A
Binding site50a divalent metal cation 6 (UniProtKB | ChEBI); in cluster A
Binding site54a divalent metal cation 4 (UniProtKB | ChEBI); in cluster A
Binding site56a divalent metal cation 5 (UniProtKB | ChEBI); in cluster A
Binding site56a divalent metal cation 7 (UniProtKB | ChEBI); in cluster A
Binding site64a divalent metal cation 7 (UniProtKB | ChEBI); in cluster A
Binding site66a divalent metal cation 7 (UniProtKB | ChEBI); in cluster A
Binding site67a divalent metal cation 6 (UniProtKB | ChEBI); in cluster A
Binding site67a divalent metal cation 7 (UniProtKB | ChEBI); in cluster A

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentnucleus
Molecular Functionmetal ion binding
Biological Processcellular response to cadmium ion
Biological Processcellular response to copper ion
Biological Processcellular response to zinc ion
Biological Processdetoxification of copper ion
Biological Processintracellular zinc ion homeostasis

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Metallothionein
  • Short names
    MT

Gene names

    • Name
      mt

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Chondrichthyes > Elasmobranchii > Galeomorphii > Galeoidea > Carcharhiniformes > Scyliorhinidae > Scyliorhinus

Accessions

  • Primary accession
    Q6J1T3

Subcellular Location

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001973191-68Metallothionein

Family & Domains

Domain

Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.

Sequence similarities

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    68
  • Mass (Da)
    6,957
  • Last updated
    2004-07-05 v1
  • Checksum
    048157EF8400A6A9
MSDTKPCVCLDGSCSCENTCRCSDCRCPTSKAGRCQKSCCSCCPAGCTNCANGCVCKGKASDKCSCCS

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AY605090
EMBL· GenBank· DDBJ
AAT35554.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

Disclaimer

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