Q6IWH7 · ANO7_HUMAN
- ProteinAnoctamin-7
- GeneANO7
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids933 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Does not exhibit calcium-activated chloride channel (CaCC) activity (PubMed:22075693).
May play a role in cell-cell interactions (PubMed:17308099).
Miscellaneous
Catalytic activity
- a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out)This reaction proceeds in the forward direction.
- a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine(out) = a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine(in)This reaction proceeds in the forward direction.
- a 1,2-diacyl-sn-glycero-3-phosphocholine(in) = a 1,2-diacyl-sn-glycero-3-phosphocholine(out)This reaction proceeds in the backward direction.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | anchoring junction | |
Cellular Component | cytosol | |
Cellular Component | endoplasmic reticulum | |
Cellular Component | plasma membrane | |
Molecular Function | chloride channel activity | |
Molecular Function | intracellularly calcium-gated chloride channel activity | |
Molecular Function | protein dimerization activity | |
Biological Process | calcium activated phospholipid scrambling | |
Biological Process | chloride transmembrane transport | |
Biological Process | monoatomic ion transmembrane transport |
Keywords
- Biological process
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameAnoctamin-7
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ6IWH7
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Isoform 1
Isoform 2
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-355 | Cytoplasmic | ||||
Sequence: MRMAATAWAGLQGPPLPTLCPAVRTGLYCRDQAHAERWAMTSETSSGSHCARSRMLRRRAQEEDSTVLIDVSPPEAEKRGSYGSTAHASEPGGQQAAACRAGSPAKPRIADFVLVWEEDLKLDRQQDSAARDRTDMHRTWRETFLDNLRAAGLCVDQQDVQDGNTTVHYALLSASWAVLCYYAEDLRLKLPLQELPNQASNWSAGLLAWLGIPNVLLEVVPDVPPEYYSCRFRVNKLPRFLGSDNQDTFFTSTKRHQILFEILAKTPYGHEKKNLLGIHQLLAEGVLSAAFPLHDGPFKTPPEGPQAPRLNQRQVLFQHWARWGKWNKYQPLDHVRRYFGEKVALYFAWLGFYTG | ||||||
Transmembrane | 356-376 | Helical | ||||
Sequence: WLLPAAVVGTLVFLVGCFLVF | ||||||
Topological domain | 377-420 | Extracellular | ||||
Sequence: SDIPTQELCGSKDSFEMCPLCLDCPFWLLSSACALAQAGRLFDH | ||||||
Transmembrane | 421-441 | Helical | ||||
Sequence: GGTVFFSLFMALWAVLLLEYW | ||||||
Topological domain | 442-499 | Cytoplasmic | ||||
Sequence: KRKSATLAYRWDCSDYEDTEERPRPQFAASAPMTAPNPITGEDEPYFPERSRARRMLA | ||||||
Transmembrane | 500-520 | Helical | ||||
Sequence: GSVVIVVMVAVVVMCLVSIIL | ||||||
Topological domain | 521-550 | Extracellular | ||||
Sequence: YRAIMAIVVSRSGNTLLAAWASRIASLTGS | ||||||
Transmembrane | 551-571 | Helical | ||||
Sequence: VVNLVFILILSKIYVSLAHVL | ||||||
Topological domain | 572-588 | Cytoplasmic | ||||
Sequence: TRWEMHRTQTKFEDAFT | ||||||
Transmembrane | 589-609 | Helical | ||||
Sequence: LKVFIFQFVNFYSSPVYIAFF | ||||||
Topological domain | 610-714 | Extracellular | ||||
Sequence: KGRFVGYPGNYHTLFGVRNEECAAGGCLIELAQELLVIMVGKQVINNMQEVLIPKLKGWWQKFRLRSKKRKAGASAGASQGPWEDDYELVPCEGLFDEYLEMVLQ | ||||||
Transmembrane | 715-735 | Helical | ||||
Sequence: FGFVTIFVAACPLAPLFALLN | ||||||
Topological domain | 736-763 | Cytoplasmic | ||||
Sequence: NWVEIRLDARKFVCEYRRPVAERAQDIG | ||||||
Transmembrane | 764-784 | Helical | ||||
Sequence: IWFHILAGLTHLAVISNAFLL | ||||||
Topological domain | 785-843 | Extracellular | ||||
Sequence: AFSSDFLPRAYYRWTRAHDLRGFLNFTLARAPSSFAAAHNRTCRYRAFRDDDGHYSQTY | ||||||
Transmembrane | 844-864 | Helical | ||||
Sequence: WNLLAIRLAFVIVFEHVVFSV | ||||||
Topological domain | 865-933 | Cytoplasmic | ||||
Sequence: GRLLDLLVPDIPESVEIKVKREYYLAKQALAENEVLFGTNGTKDEQPEGSELSSHWTPFTVPKASQLQQ |
Keywords
- Cellular component
Disease & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_032616 | 67 | in dbSNP:rs2302054 | |||
Sequence: V → I | ||||||
Natural variant | VAR_065166 | 912 | in dbSNP:rs7590653 | |||
Sequence: E → K |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 1,266 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for chain, modified residue (large scale data), glycosylation.
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Chain | PRO_0000289326 | 1-933 | UniProt | Anoctamin-7 | |||
Sequence: MRMAATAWAGLQGPPLPTLCPAVRTGLYCRDQAHAERWAMTSETSSGSHCARSRMLRRRAQEEDSTVLIDVSPPEAEKRGSYGSTAHASEPGGQQAAACRAGSPAKPRIADFVLVWEEDLKLDRQQDSAARDRTDMHRTWRETFLDNLRAAGLCVDQQDVQDGNTTVHYALLSASWAVLCYYAEDLRLKLPLQELPNQASNWSAGLLAWLGIPNVLLEVVPDVPPEYYSCRFRVNKLPRFLGSDNQDTFFTSTKRHQILFEILAKTPYGHEKKNLLGIHQLLAEGVLSAAFPLHDGPFKTPPEGPQAPRLNQRQVLFQHWARWGKWNKYQPLDHVRRYFGEKVALYFAWLGFYTGWLLPAAVVGTLVFLVGCFLVFSDIPTQELCGSKDSFEMCPLCLDCPFWLLSSACALAQAGRLFDHGGTVFFSLFMALWAVLLLEYWKRKSATLAYRWDCSDYEDTEERPRPQFAASAPMTAPNPITGEDEPYFPERSRARRMLAGSVVIVVMVAVVVMCLVSIILYRAIMAIVVSRSGNTLLAAWASRIASLTGSVVNLVFILILSKIYVSLAHVLTRWEMHRTQTKFEDAFTLKVFIFQFVNFYSSPVYIAFFKGRFVGYPGNYHTLFGVRNEECAAGGCLIELAQELLVIMVGKQVINNMQEVLIPKLKGWWQKFRLRSKKRKAGASAGASQGPWEDDYELVPCEGLFDEYLEMVLQFGFVTIFVAACPLAPLFALLNNWVEIRLDARKFVCEYRRPVAERAQDIGIWFHILAGLTHLAVISNAFLLAFSSDFLPRAYYRWTRAHDLRGFLNFTLARAPSSFAAAHNRTCRYRAFRDDDGHYSQTYWNLLAIRLAFVIVFEHVVFSVGRLLDLLVPDIPESVEIKVKREYYLAKQALAENEVLFGTNGTKDEQPEGSELSSHWTPFTVPKASQLQQ | |||||||
Modified residue (large scale data) | 81 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Glycosylation | 809 | UniProt | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | |||||||
Glycosylation | 824 | UniProt | N-linked (GlcNAc...) asparagine | ||||
Sequence: N |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Induction
Gene expression databases
Organism-specific databases
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 43-101 | Disordered | ||||
Sequence: ETSSGSHCARSRMLRRRAQEEDSTVLIDVSPPEAEKRGSYGSTAHASEPGGQQAAACRA | ||||||
Region | 902-933 | Disordered | ||||
Sequence: GTNGTKDEQPEGSELSSHWTPFTVPKASQLQQ | ||||||
Compositional bias | 903-933 | Polar residues | ||||
Sequence: TNGTKDEQPEGSELSSHWTPFTVPKASQLQQ |
Sequence similarities
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoforms
- Sequence statusComplete
This entry describes 3 isoforms produced by Alternative splicing.
Q6IWH7-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- SynonymsNGEP-L
- Length933
- Mass (Da)105,532
- Last updated2011-05-31 v2
- ChecksumD6FD42578A4BD773
Q6IWH7-2
- Name2
- SynonymsNGEP-S
Q6IWH7-3
- Name3
- SynonymsD-TMPP
Computationally mapped potential isoform sequences
There are 4 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A6Q8JT31 | A0A6Q8JT31_HUMAN | ANO7 | 125 | ||
A0A6Q8JTU6 | A0A6Q8JTU6_HUMAN | ANO7 | 829 | ||
A0A6I8PRE6 | A0A6I8PRE6_HUMAN | ANO7 | 879 | ||
H7C220 | H7C220_HUMAN | ANO7 | 185 |
Features
Showing features for alternative sequence, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_026004 | 110 | in isoform 2 and isoform 3 | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_026005 | 158-180 | in isoform 2 | |||
Sequence: QDVQDGNTTVHYALLSASWAVLC → VRGGCHGQGPRPCIHSVTHDLAA | ||||||
Alternative sequence | VSP_026006 | 181-933 | in isoform 2 | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_026007 | 859 | in isoform 3 | |||
Sequence: H → VAEAPAGSPIHGMRPRPCALPNSSTW | ||||||
Alternative sequence | VSP_026008 | 860-933 | in isoform 3 | |||
Sequence: Missing | ||||||
Compositional bias | 903-933 | Polar residues | ||||
Sequence: TNGTKDEQPEGSELSSHWTPFTVPKASQLQQ |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AY617079 EMBL· GenBank· DDBJ | AAT40139.1 EMBL· GenBank· DDBJ | mRNA | ||
AY617080 EMBL· GenBank· DDBJ | AAT40140.1 EMBL· GenBank· DDBJ | mRNA | ||
AC005237 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC104841 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC111201 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |