The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).The MGC Project TeamView abstractCited forNUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]StrainC57BL/6JTissueEmbryoCategoriesSequencesSourceUniProtKB unreviewed (TrEMBL)PubMedEurope PMCGenome Res. 14:2121-2127 (2004)Cited in99+99+
Human osteoclast-like cells are formed from peripheral blood mononuclear cells in a coculture with SaOS-2 cells transfected with the parathyroid hormone (PTH)/PTH-related protein receptor gene.Matsuzaki K., Katayama K., Takahashi Y., Nakamura I., Udagawa N., Tsurukai T., Nishinakamura R., Toyama Y., Yabe Y.[...], Suda T.View abstractCategoriesSequencesSourceMGI: 1270849PubMedEurope PMCEndocrinology 140:925-932 (1999)Mapped to41
Disruption of the p70(s6k)/p85(s6k) gene reveals a small mouse phenotype and a new functional S6 kinase.Shima H., Pende M., Chen Y., Fumagalli S., Thomas G., Kozma S.C.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1270849PubMedEurope PMCEMBO J. 17:6649-6659 (1998)Cited in1Mapped to14
Targeted disruption of p70(s6k) defines its role in protein synthesis and rapamycin sensitivity.Kawasome H., Papst P., Webb S., Keller G.M., Johnson G.L., Gelfand E.W., Terada N.View abstractCategoriesFunctionSourceMGI: 1270849PubMedEurope PMCProc Natl Acad Sci U S A 95:5033-5038 (1998)Mapped to16
Structural and functional analysis of pp70S6k.Cheatham L., Monfar M., Chou M.M., Blenis J.View abstractCategoriesSequencesSourceMGI: 1270849PubMedEurope PMCProc. Natl. Acad. Sci. U.S.A. 92:11696-11700 (1995)Cited in1Mapped to16
S6K1 deficiency in tumor stroma impairs lung metastasis of melanoma in mice.Kim D.E., Roh H.S., Kim G.H., Bhang D.H., Um S.H., Singh R., Baek K.H.View abstractAnnotationS6K1 deficiency in tumor stroma impairs lung metastasis of melanoma in mice.SourceGeneRif: 72508, MGI: 1270849PubMedEurope PMCBiochem Biophys Res Commun 696:149469-149469 (2024)Mapped to7
Chronic mild stress leads to anxiety-like behavior and decreased p70 S6K1 activity in the hippocampus of male mice.David J., Mousset M., Trombetti K., Sayasouk B., Neilsen C., Suorsa P., Ruben M., Ruben E., Thiessen J.[...], Huynh T.N.View abstractAnnotationChronic mild stress leads to anxiety-like behavior and decreased p70 S6K1 activity in the hippocampus of male mice.SourceGeneRif: 72508PubMedEurope PMCPhysiol Behav 273:114377-114377 (2024)Mapped to6
Impairment of serine transport across the blood-brain barrier by deletion of Slc38a5 causes developmental delay and motor dysfunction.Radzishevsky I., Odeh M., Bodner O., Zubedat S., Shaulov L., Litvak M., Esaki K., Yoshikawa T., Agranovich B.[...], Wolosker H.View abstractSourceMGI: 1270849PubMedEurope PMCProc Natl Acad Sci U S A 120:e2302780120-e2302780120 (2023)Mapped to98
Enhanced BMP signaling leads to enlarged nasal cartilage formation in mice.Yamaguchi H., Swaminathan S., Mishina Y., Komatsu Y.View abstractSourceMGI: 1270849PubMedEurope PMCBiochem Biophys Res Commun 678:173-178 (2023)Mapped to85
Unconventional myosin VI in the heart: Involvement in cardiac dysfunction progressing with age.Karatsai O., Lehka L., Wojton D., Grabowska A.I., Duda M.K., Lenartowski R., Redowicz M.J.View abstractCategoriesFunctionSourceMGI: 1270849PubMedEurope PMCBiochim Biophys Acta Mol Basis Dis 1869:166748-166748 (2023)Mapped to99+
LCRMP-1 is required for spermatogenesis and stabilises spermatid F-actin organization via the PI3K-Akt pathway.Chang J.H., Chou C.H., Wu J.C., Liao K.M., Luo W.J., Hsu W.L., Chen X.R., Yu S.L., Pan S.H.[...], Su K.Y.View abstractCategoriesFunctionSourceMGI: 1270849PubMedEurope PMCCommun Biol 6:389-389 (2023)Mapped to68
Ring domains are essential for GATOR2-dependent mTORC1 activation.Jiang C., Dai X., He S., Zhou H., Fang L., Guo J., Liu S., Zhang T., Pan W.[...], Wei W.View abstractCategoriesFunction, InteractionSourceMGI: 1270849PubMedEurope PMCMol. Cell 83:74-89 (2023)Cited in10Mapped to43
Muscle 4EBP1 activation modifies the structure and function of the neuromuscular junction in mice.Ang S.J., Crombie E.M., Dong H., Tan K.T., Hernando A., Yu D., Adamson S., Kim S., Withers D.J.[...], Tsai S.Y.View abstractCategoriesFunctionSourceMGI: 1270849PubMedEurope PMCNat Commun 13:7792-7792 (2022)Mapped to12
Activation of eIF4E-binding-protein-1 rescues mTORC1-induced sarcopenia by expanding lysosomal degradation capacity.Crombie E.M., Kim S., Adamson S., Dong H., Lu T.C., Wu Y., Wu Y., Levy Y., Stimple N.[...], Tsai S.Y.View abstractAnnotationActivation of eIF4E-binding-protein-1 rescues mTORC1-induced sarcopenia by expanding lysosomal degradation capacity.CategoriesFunctionSourceGeneRif: 72508PubMedEurope PMCJ Cachexia Sarcopenia Muscle 14:198-213 (2023)Mapped to18
Destabilization of TP53 by USP10 is essential for neonatal autophagy and survival.Li H., Li C., Zhai W., Zhang X., Li L., Wu B., Yu B., Zhang P., Li J.[...], Zhang L.View abstractCategoriesFunctionSourceMGI: 1270849PubMedEurope PMCCell Rep 41:111435-111435 (2022)Mapped to99+
The Effects of Maternal Intake of EPA and DHA Enriched Diet During Pregnancy and Lactation on Offspring's Muscle Development and Energy Homeostasis.Ghnaimawi S., Zhang S., Baum J.I., Huang Y.View abstractCategoriesFunctionSourceMGI: 1270849PubMedEurope PMCFront Physiol 13:881624-881624 (2022)Mapped to99+
<i>Tsc1</i> Haploinsufficiency Leads to Pax2 Dysregulation in the Developing Murine Cerebellum.Serra I., Stravs A., Osorio C., Oyaga M.R., Schonewille M., Tudorache C., Badura A.View abstractCategoriesFunctionSourceMGI: 1270849PubMedEurope PMCFront Mol Neurosci 15:831687-831687 (2022)Mapped to80
Hbxip is essential for murine embryogenesis and regulates embryonic stem cell differentiation through activating mTORC1.Qin Y., Ni P., Zhang Q., Wang X., Du X., Yin Z., Wang L., Ye L., Chen L.View abstractCategoriesFunction, InteractionSourceMGI: 1270849PubMedEurope PMCDevelopment 149:dev200527-dev200527 (2022)Mapped to28
S6K1 controls adiponectin expression by inducing a transcriptional switch: BMAL1-to-EZH2.Yi S.A., Jeon Y.J., Lee M.G., Nam K.H., Ann S., Lee J., Han J.W.View abstractAnnotationS6K1 controls adiponectin expression by inducing a transcriptional switch: BMAL1-to-EZH2.CategoriesFunctionSourceGeneRif: 72508, MGI: 1270849PubMedEurope PMCExp Mol Med 54:324-333 (2022)Mapped to7
GATOR2 complex-mediated amino acid signaling regulates brain myelination.Yu Z., Yang Z., Ren G., Wang Y., Luo X., Zhu F., Yu S., Jia L., Chen M.[...], Xiao B.View abstractCategoriesFunctionSourceMGI: 1270849PubMedEurope PMCProc. Natl. Acad. Sci. U.S.A. 119:0-0 (2022)Cited in1Mapped to79
OTUB1 regulates lung development, adult lung tissue homeostasis, and respiratory control.Ruiz-Serrano A., Monne Rodriguez J.M., Gunter J., Sherman S.P.M., Jucht A.E., Fluechter P., Volkova Y.L., Pfundstein S., Pellegrini G.[...], Scholz C.C.View abstractCategoriesSequences, Phenotypes & VariantsSourceMGI: 1270849PubMedEurope PMCFASEB J 35:e22039-e22039 (2021)Mapped to45
MEK-inhibitor-mediated rescue of skeletal myopathy caused by activating Hras mutation in a Costello syndrome mouse model.Tidyman W.E., Goodwin A.F., Maeda Y., Klein O.D., Rauen K.A.View abstractCategoriesFunctionSourceMGI: 1270849PubMedEurope PMCDis Model Mech 15:dmm049166-dmm049166 (2022)Mapped to74
p70 Ribosomal Protein S6 Kinase Is a Checkpoint of Human Hepatic Stellate Cell Activation and Liver Fibrosis in Mice.Reiter F.P., Ye L., Ofner A., Schiergens T.S., Ziesch A., Brandl L., Ben Khaled N., Hohenester S., Wimmer R.[...], De Toni E.N.View abstractAnnotationp70 Ribosomal Protein S6 Kinase Is a Checkpoint of Human Hepatic Stellate Cell Activation and Liver Fibrosis in Mice.CategoriesFunctionSourceGeneRif: 72508PubMedEurope PMCCell Mol Gastroenterol Hepatol 13:95-112 (2022)Mapped to6
TLR5 Supports Development of Placental Labyrinthine Zone in Mice.Yiu J.H.C., Cheung S.W.M., Cai J., Chan K.S., Chen J., Cheong L.Y., Chau H.T., Xu A., Li R.H.W., Woo C.W.View abstractCategoriesFunctionSourceMGI: 1270849PubMedEurope PMCFront Cell Dev Biol 9:711253-711253 (2021)Mapped to99+
Genetic Modulation of Initial Sensitivity to Delta9-Tetrahydrocannabinol (THC) Among the BXD Family of Mice.Parks C., Rogers C.M., Prins P., Williams R.W., Chen H., Jones B.C., Moore B.M., Mulligan M.K.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1270849PubMedEurope PMCFront Genet 12:659012-659012 (2021)Mapped to40