our data suggest that Setd5 is required for maintaining PGC-associated genes and Setd5-associated protein complexes containing Tbl1xr1 and Ctr9 which in turn are likely involved in regulating germ cell-related genes in mESCs
these data propose a novel feed-forward loop of IL-17 transcriptional regulatory circuit via IL-6-mediated repression of CTR9 which is a transcriptional repressor of IL-17.
MLL interacts directly with the polymerase associated factor complex (PAFc) via Paf1 and CTR9. PAFc augments MLL and MLL-AF9 mediated transcriptional activation of Hoxa9 and their interaction is essential for leukemogenesis.
CTR9 participates in the transcription of IL-6-responsive genes through the regulation of DNA association of STAT3 and modification of histone methylation
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