Q6IQ55 · TTBK2_HUMAN
- ProteinTau-tubulin kinase 2
- GeneTTBK2
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids1244 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Phosphorylates MPHOSPH9 which promotes its ubiquitination and proteasomal degradation, loss of MPHOSPH9 facilitates the removal of the CP110-CEP97 complex (a negative regulator of ciliogenesis) from the mother centrioles, promoting the initiation of ciliogenesis (PubMed:30375385).
Required for recruitment of CPLANE2 and INTU to the mother centriole (By similarity).
Catalytic activity
- ATP + L-seryl-[protein] = ADP + H+ + O-phospho-L-seryl-[protein]
Kinetics
KM | SUBSTRATE | pH | TEMPERATURE[C] | NOTES | EVIDENCE | |
---|---|---|---|---|---|---|
18 μM | RRKDLHDDEEDEAMSIYpA peptide | |||||
141 μM | RRKDLHDDEEDEAMSIYA peptide |
Vmax | pH | TEMPERATURE[C] | NOTES | EVIDENCE | |
---|---|---|---|---|---|
76 μmol/min/mg | with RRKDLHDDEEDEAMSIYpA peptide as substrate | ||||
66 μmol/min/mg | with RRKDLHDDEEDEAMSIYA peptide as substrate |
Features
Showing features for binding site, active site.
GO annotations
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameTau-tubulin kinase 2
- EC number
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ6IQ55
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Keywords
- Cellular component
Disease & Variants
Involvement in disease
Spinocerebellar ataxia 11 (SCA11)
- Note
- DescriptionSpinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA11 is an autosomal dominant cerebellar ataxia (ADCA). It is a relatively benign, late-onset, slowly progressive neurologic disorder.
- See alsoMIM:604432
Features
Showing features for natural variant, mutagenesis.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_041261 | 8 | in dbSNP:rs6493068 | |||
Sequence: L → P | ||||||
Mutagenesis | 50 | Leads to inactivation/destabilization of the protein. | ||||
Sequence: K → E or A | ||||||
Natural variant | VAR_041262 | 120 | in dbSNP:rs35328266 | |||
Sequence: R → Q | ||||||
Mutagenesis | 143 | Leads to inactivation/destabilization of the protein. | ||||
Sequence: K → E or A | ||||||
Mutagenesis | 163 | Abolishes serine/threonine-protein kinase activity. | ||||
Sequence: D → A | ||||||
Mutagenesis | 181 | Impaired serine/threonine-protein kinase activity. | ||||
Sequence: R → E or A | ||||||
Mutagenesis | 184 | Impaired serine/threonine-protein kinase activity. | ||||
Sequence: A → E or G | ||||||
Natural variant | VAR_041263 | 313 | in dbSNP:rs56017612 | |||
Sequence: T → A | ||||||
Natural variant | VAR_076383 | 367 | in dbSNP:rs764753481 | |||
Sequence: K → I | ||||||
Natural variant | VAR_041264 | 440 | in dbSNP:rs56311523 | |||
Sequence: V → M | ||||||
Natural variant | VAR_041265 | 500 | in dbSNP:rs56039839 | |||
Sequence: R → P | ||||||
Natural variant | VAR_041266 | 635 | in a lung small cell carcinoma sample; somatic mutation | |||
Sequence: D → G | ||||||
Natural variant | VAR_076384 | 724 | in dbSNP:rs201524659 | |||
Sequence: G → E | ||||||
Natural variant | VAR_069052 | 842 | found in a patient with SCA11; uncertain significance; dbSNP:rs202004988 | |||
Sequence: E → G | ||||||
Natural variant | VAR_041267 | 1062 | in dbSNP:rs55833708 | |||
Sequence: T → I | ||||||
Natural variant | VAR_041268 | 1084 | in dbSNP:rs34348991 | |||
Sequence: T → M | ||||||
Natural variant | VAR_041269 | 1097 | in dbSNP:rs55796513 | |||
Sequence: V → A | ||||||
Natural variant | VAR_069053 | 1110 | found in a patient with SCA11; uncertain significance; dbSNP:rs146279300 | |||
Sequence: R → H | ||||||
Natural variant | VAR_041270 | 1122 | in dbSNP:rs56142516 | |||
Sequence: P → R | ||||||
Natural variant | VAR_041271 | 1241 | in dbSNP:rs36104367 | |||
Sequence: K → T |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 1,278 variants from UniProt as well as other sources including ClinVar and dbSNP.
Keywords
- Disease
Organism-specific databases
Miscellaneous
Chemistry
Genetic variation databases
PTM/Processing
Features
Showing features for chain, modified residue (large scale data), modified residue.
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Chain | PRO_0000234342 | 1-1244 | UniProt | Tau-tubulin kinase 2 | |||
Sequence: MSGGGEQLDILSVGILVKERWKVLRKIGGGGFGEIYDALDMLTRENVALKVESAQQPKQVLKMEVAVLKKLQGKDHVCRFIGCGRNDRFNYVVMQLQGRNLADLRRSQSRGTFTISTTLRLGRQILESIESIHSVGFLHRDIKPSNFAMGRFPSTCRKCYMLDFGLARQFTNSCGDVRPPRAVAGFRGTVRYASINAHRNREMGRHDDLWSLFYMLVEFVVGQLPWRKIKDKEQVGSIKERYDHRLMLKHLPPEFSIFLDHISSLDYFTKPDYQLLTSVFDNSIKTFGVIESDPFDWEKTGNDGSLTTTTTSTTPQLHTRLTPAAIGIANATPIPGDLLRENTDEVFPDEQLSDGENGIPVGVSPDKLPGSLGHPRPQEKDVWEEMDANKNKIKLGICKAATEEENSHGQANGLLNAPSLGSPIRVRSEITQPDRDIPLVRKLRSIHSFELEKRLTLEPKPDTDKFLETCLEKMQKDTSAGKESILPALLHKPCVPAVSRTDHIWHYDEEYLPDASKPASANTPEQADGGGSNGFIAVNLSSCKQEIDSKEWVIVDKEQDLQDFRTNEAVGHKTTGSPSDEEPEVLQVLEASPQDEKLQLGPWAENDHLKKETSGVVLALSAEGPPTAASEQYTDRLELQPGAASQFIAATPTSLMEAQAEGPLTAITIPRPSVASTQSTSGSFHCGQQPEKKDLQPMEPTVELYSPRENFSGLVVTEGEPPSGGSRTDLGLQIDHIGHDMLPNIRESNKSQDLGPKELPDHNRLVVREFENLPGETEEKSILLESDNEDEKLSRGQHCIEISSLPGDLVIVEKDHSATTEPLDVTKTQTFSVVPNQDKNNEIMKLLTVGTSEISSRDIDPHVEGQIGQVAEMQKNKISKDDDIMSEDLPGHQGDLSTFLHQEGKREKITPRNGELFHCVSENEHGAPTRKDMVRSSFVTRHSRIPVLAQEIDSTLESSSPVSAKEKLLQKKAYQPDLVKLLVEKRQFKSFLGDLSSASDKLLEEKLATVPAPFCEEEVLTPFSRLTVDSHLSRSAEDSFLSPIISQSRKSKIPRPVSWVNTDQVNSSTSSQFFPRPPPGKPPTRPGVEARLRRYKVLGSSNSDSDLFSRLAQILQNGSQKPRSTTQCKSPGSPHNPKTPPKSPVVPRRSPSASPRSSSLPRTSSSSPSRAGRPHHDQRSSSPHLGRSKSPPSHSGSSSSRRSCQQEHCKPSKNGLKGSGSLHHHSASTKTPQGKSKPASKLSR | |||||||
Modified residue (large scale data) | 322 | PRIDE | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue (large scale data) | 371 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 402 | PRIDE | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue (large scale data) | 407 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 419 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 422 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 428 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue | 445 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 445 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 448 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 478 | PRIDE | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue (large scale data) | 479 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 579 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 777 | PRIDE | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue (large scale data) | 781 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue | 786 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 786 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 794 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 817 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 820 | PRIDE | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue | 1103 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 1103 | PRIDE | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Interaction
Subunit
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | Q6IQ55 | CEP164 Q9UPV0 | 5 | EBI-1050303, EBI-3937015 | |
BINARY | Q6IQ55 | KLHL12 Q53G59 | 6 | EBI-1050303, EBI-740929 | |
BINARY | Q6IQ55-3 | COPS3 Q9UNS2 | 3 | EBI-25930156, EBI-350590 | |
BINARY | Q6IQ55-3 | SKIC8 Q9GZS3 | 3 | EBI-25930156, EBI-358545 |
Protein-protein interaction databases
Chemistry
Miscellaneous
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 21-284 | Protein kinase | ||||
Sequence: WKVLRKIGGGGFGEIYDALDMLTRENVALKVESAQQPKQVLKMEVAVLKKLQGKDHVCRFIGCGRNDRFNYVVMQLQGRNLADLRRSQSRGTFTISTTLRLGRQILESIESIHSVGFLHRDIKPSNFAMGRFPSTCRKCYMLDFGLARQFTNSCGDVRPPRAVAGFRGTVRYASINAHRNREMGRHDDLWSLFYMLVEFVVGQLPWRKIKDKEQVGSIKERYDHRLMLKHLPPEFSIFLDHISSLDYFTKPDYQLLTSVFDNSI | ||||||
Region | 674-694 | Disordered | ||||
Sequence: VASTQSTSGSFHCGQQPEKKD | ||||||
Compositional bias | 1052-1074 | Polar residues | ||||
Sequence: KIPRPVSWVNTDQVNSSTSSQFF | ||||||
Region | 1052-1088 | Disordered | ||||
Sequence: KIPRPVSWVNTDQVNSSTSSQFFPRPPPGKPPTRPGV | ||||||
Compositional bias | 1116-1133 | Polar residues | ||||
Sequence: QNGSQKPRSTTQCKSPGS | ||||||
Region | 1116-1244 | Disordered | ||||
Sequence: QNGSQKPRSTTQCKSPGSPHNPKTPPKSPVVPRRSPSASPRSSSLPRTSSSSPSRAGRPHHDQRSSSPHLGRSKSPPSHSGSSSSRRSCQQEHCKPSKNGLKGSGSLHHHSASTKTPQGKSKPASKLSR | ||||||
Compositional bias | 1134-1148 | Pro residues | ||||
Sequence: PHNPKTPPKSPVVPR | ||||||
Compositional bias | 1150-1171 | Polar residues | ||||
Sequence: SPSASPRSSSLPRTSSSSPSRA | ||||||
Compositional bias | 1184-1212 | Polar residues | ||||
Sequence: HLGRSKSPPSHSGSSSSRRSCQQEHCKPS | ||||||
Compositional bias | 1219-1244 | Polar residues | ||||
Sequence: SGSLHHHSASTKTPQGKSKPASKLSR |
Sequence similarities
Phylogenomic databases
Family and domain databases
Sequence & Isoforms
- Sequence statusComplete
This entry describes 3 isoforms produced by Alternative splicing.
Q6IQ55-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length1,244
- Mass (Da)137,412
- Last updated2006-10-17 v2
- ChecksumEAB8FC28370966DE
Q6IQ55-2
- Name2
- Differences from canonical
- 1-72: MSGGGEQLDILSVGILVKERWKVLRKIGGGGFGEIYDALDMLTRENVALKVESAQQPKQVLKMEVAVLKKLQ → MES
- 1233-1244: QGKSKPASKLSR → PREE
Q6IQ55-3
- Name3
Computationally mapped potential isoform sequences
There are 4 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
H3BTY5 | H3BTY5_HUMAN | TTBK2 | 143 | ||
H3BQ25 | H3BQ25_HUMAN | TTBK2 | 117 | ||
H3BMY7 | H3BMY7_HUMAN | TTBK2 | 84 | ||
A0A0B4J292 | A0A0B4J292_HUMAN | TTBK2 | 443 |
Features
Showing features for alternative sequence, sequence conflict, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_018272 | 1-72 | in isoform 2 | |||
Sequence: MSGGGEQLDILSVGILVKERWKVLRKIGGGGFGEIYDALDMLTRENVALKVESAQQPKQVLKMEVAVLKKLQ → MES | ||||||
Sequence conflict | 309 | in Ref. 1; BAD18523 | ||||
Sequence: T → I | ||||||
Sequence conflict | 456 | in Ref. 1; BAD18523 | ||||
Sequence: T → A | ||||||
Alternative sequence | VSP_018273 | 470-478 | in isoform 3 | |||
Sequence: CLEKMQKDT → WYKIVYFSF | ||||||
Alternative sequence | VSP_018274 | 479-1244 | in isoform 3 | |||
Sequence: Missing | ||||||
Sequence conflict | 557 | in Ref. 1; BAD18523 | ||||
Sequence: K → N | ||||||
Compositional bias | 1052-1074 | Polar residues | ||||
Sequence: KIPRPVSWVNTDQVNSSTSSQFF | ||||||
Compositional bias | 1116-1133 | Polar residues | ||||
Sequence: QNGSQKPRSTTQCKSPGS | ||||||
Compositional bias | 1134-1148 | Pro residues | ||||
Sequence: PHNPKTPPKSPVVPR | ||||||
Compositional bias | 1150-1171 | Polar residues | ||||
Sequence: SPSASPRSSSLPRTSSSSPSRA | ||||||
Compositional bias | 1184-1212 | Polar residues | ||||
Sequence: HLGRSKSPPSHSGSSSSRRSCQQEHCKPS | ||||||
Compositional bias | 1219-1244 | Polar residues | ||||
Sequence: SGSLHHHSASTKTPQGKSKPASKLSR | ||||||
Alternative sequence | VSP_018275 | 1233-1244 | in isoform 2 | |||
Sequence: QGKSKPASKLSR → PREE |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AK131372 EMBL· GenBank· DDBJ | BAD18523.1 EMBL· GenBank· DDBJ | mRNA | ||
AC068727 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC090510 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BC041876 EMBL· GenBank· DDBJ | AAH41876.1 EMBL· GenBank· DDBJ | mRNA | ||
BC071556 EMBL· GenBank· DDBJ | AAH71556.1 EMBL· GenBank· DDBJ | mRNA | ||
AB020654 EMBL· GenBank· DDBJ | BAA74870.1 EMBL· GenBank· DDBJ | mRNA |