Q6IMI6 · ST1C3_HUMAN
- ProteinSulfotransferase 1C3
- GeneSULT1C3
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids304 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Isoform 1
Isoform 2
Miscellaneous
Catalytic activity
- 3'-phosphoadenylyl sulfate + an alcohol = adenosine 3',5'-bisphosphate + an alkyl sulfate + H+
- 3'-phosphoadenylyl sulfate + lithocholate = adenosine 3',5'-bisphosphate + H+ + lithocholate sulfateThis reaction proceeds in the forward direction.
Kinetics
KM | SUBSTRATE | pH | TEMPERATURE[C] | NOTES | EVIDENCE | |
---|---|---|---|---|---|---|
11.29 μM | 3,3',5,5'-tetrachloro-4,4'-biphenyldiol | |||||
35.17 μM | lithocholate |
Vmax | pH | TEMPERATURE[C] | NOTES | EVIDENCE | |
---|---|---|---|---|---|
5.45 nmol/min/mg | for 3,3',5,5'-tetrachloro-4,4'-biphenyldiol | ||||
0.52 nmol/min/mg | for lithocholate |
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 56-61 | 3'-phosphoadenylyl sulfate (UniProtKB | ChEBI) | ||||
Sequence: KSGTTW | ||||||
Binding site | 115-117 | substrate | ||||
Sequence: KTH | ||||||
Active site | 117 | Proton acceptor | ||||
Sequence: H | ||||||
Binding site | 139 | 3'-phosphoadenylyl sulfate (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 147 | 3'-phosphoadenylyl sulfate (UniProtKB | ChEBI) | ||||
Sequence: S | ||||||
Binding site | 202 | 3'-phosphoadenylyl sulfate (UniProtKB | ChEBI) | ||||
Sequence: Y | ||||||
Binding site | 236-241 | 3'-phosphoadenylyl sulfate (UniProtKB | ChEBI) | ||||
Sequence: TSFDVM | ||||||
Binding site | 264-268 | 3'-phosphoadenylyl sulfate (UniProtKB | ChEBI) | ||||
Sequence: FMRKG |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | 3'-phosphoadenosine 5'-phosphosulfate binding | |
Molecular Function | alcohol sulfotransferase activity | |
Molecular Function | aryl sulfotransferase activity | |
Molecular Function | bile-salt sulfotransferase activity | |
Biological Process | 3'-phosphoadenosine 5'-phosphosulfate metabolic process | |
Biological Process | cholesterol metabolic process | |
Biological Process | lipid metabolic process | |
Biological Process | sulfation | |
Biological Process | sulfur compound metabolic process | |
Biological Process | xenobiotic metabolic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Chemistry
Names & Taxonomy
Protein names
- Recommended nameSulfotransferase 1C3
- EC number
- Short namesST1C3
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ6IMI6
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Disease & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_052519 | 88 | in dbSNP:rs11903659 | |||
Sequence: A → T | ||||||
Natural variant | VAR_033732 | 148 | in dbSNP:rs17035911 | |||
Sequence: Y → C | ||||||
Natural variant | VAR_033733 | 179 | in dbSNP:rs2219078 | |||
Sequence: G → R | ||||||
Natural variant | VAR_033734 | 194 | in dbSNP:rs6722745 | |||
Sequence: M → T |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 375 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Chemistry
Genetic variation databases
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000249887 | 1-304 | Sulfotransferase 1C3 | |||
Sequence: MAKIEKNAPTMEKKPELFNIMEVDGVPTLILSKEWWEKVCNFQAKPDDLILATYPKSGTTWMHEILDMILNDGDVEKCKRAQTLDRHAFLELKFPHKEKPDLEFVLEMSSPQLIKTHLPSHLIPPSIWKENCKIVYVARNPKDCLVSYYHFHRMASFMPDPQNLEEFYEKFMSGKVVGGSWFDHVKGWWAAKDMHRILYLFYEDIKKDPKREIEKILKFLEKDISEEILNKIIYHTSFDVMKQNPMTNYTTLPTSIMDHSISPFMRKGMPGDWKNYFTVAQNEEFDKDYQKKMAGSTLTFRTEI |
Proteomic databases
PTM databases
Interaction
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | Q6IMI6 | SULT2B1 O00204 | 3 | EBI-12837366, EBI-749441 |
Protein-protein interaction databases
Miscellaneous
Structure
Sequence & Isoform
- Sequence statusComplete
This entry describes 2 isoforms produced by Alternative splicing. Contains alternative exons 7 (7b) and 8 (8b) which may generate three possible splice variants containing sequences corresponding respectively to exons 7a and 8a (SULT1C3a), exons 7a and 8b (SULT1C3c) and exons 7b and 8b (SULT1C3d). So far, it is not known which isoforms are expressed.
Q6IMI6-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- SynonymsD, SULT1C3d
- Length304
- Mass (Da)35,889
- Last updated2004-07-05 v1
- Checksum5510C869578BB70C
Q6IMI6-2
- Name2
- SynonymsA, SULT1C3a
- Differences from canonical
- 208-304: DPKREIEKILKFLEKDISEEILNKIIYHTSFDVMKQNPMTNYTTLPTSIMDHSISPFMRKGMPGDWKNYFTVAQNEEFDKDYQKKMAGSTLTFRTEI → NPKHEIHKVLEFLEKTWSGDVINKIVHHTSFDVMKDNPMANHTAVPAHIFNHSISKFMRKGMPGDWKNHFTVALNENFDKHYEKKMAGSTLNFCLEI
Features
Showing features for alternative sequence.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_020583 | 208-304 | in isoform 2 | |||
Sequence: DPKREIEKILKFLEKDISEEILNKIIYHTSFDVMKQNPMTNYTTLPTSIMDHSISPFMRKGMPGDWKNYFTVAQNEEFDKDYQKKMAGSTLTFRTEI → NPKHEIHKVLEFLEKTWSGDVINKIVHHTSFDVMKDNPMANHTAVPAHIFNHSISKFMRKGMPGDWKNHFTVALNENFDKHYEKKMAGSTLNFCLEI |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AC019100 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BK001432 EMBL· GenBank· DDBJ | DAA01770.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BK001432 EMBL· GenBank· DDBJ | DAA01771.1 EMBL· GenBank· DDBJ | Genomic DNA |