Q6IMH0 · SMIP8_MOUSE

  • Protein
    Sperm microtubule inner protein 8
  • Gene
    Spmip8
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    4/5

Function

function

Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in flagellum axoneme (PubMed:37295417).
May serve to reinforce and thus stabilize the microtubule structure in the sperm flagella (PubMed:37295417).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentaxonemal A tubule inner sheath
Cellular Componentsperm flagellum
Biological Processflagellated sperm motility

Names & Taxonomy

Protein names

  • Recommended name
    Sperm microtubule inner protein 8
  • Alternative names
    • Testis, prostate and placenta-expressed protein

Gene names

    • Name
      Spmip8
    • Synonyms
      Tepp

Organism names

  • Taxonomic identifier
  • Strain
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q6IMH0
  • Secondary accessions
    • Q3SXB6
    • Q9D9K7

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Phenotypes & Variants

Disruption phenotype

Deficient mice are viable and have normal fertility.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 17 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00003257781-216Sperm microtubule inner protein 8

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed in testis.

Gene expression databases

Interaction

Subunit

Microtubule inner protein component of sperm flagellar doublet microtubules.

Protein-protein interaction databases

Miscellaneous

Family & Domains

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

Q6IMH0-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    216
  • Mass (Da)
    24,949
  • Last updated
    2004-07-05 v1
  • Checksum
    3DEFAA2AEFA07671
MAQIIDLVPWDECSAHLYASPAVLLPLERVRHPLAGVKHQLYHPALPSLRRMDMDTVKGCLSDEHCQSSTYFSKDDFNKAHFTLLGVPNKPLQCLDFTATGQKLCHKYRGGKMIPIAPGINRVDWPCFTRAIEDWSKFVSRSEEFKLPCANKRVEGFSGYAVRYLKPEVTQNWRYCLNQNPSLDRYGQKPLPFDSLNAFRRFGSHYSRINYLTPWH

Q6IMH0-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Computationally mapped potential isoform sequences

There are 5 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
D3YY82D3YY82_MOUSESpmip8174
A0A1D5RLW2A0A1D5RLW2_MOUSESpmip8147
A0A1D5RLZ0A0A1D5RLZ0_MOUSESpmip882
F6TW27F6TW27_MOUSESpmip873
F2Z458F2Z458_MOUSESpmip864

Features

Showing features for alternative sequence, sequence conflict.

TypeIDPosition(s)Description
Alternative sequenceVSP_0324041-112in isoform 2
Sequence conflict142in Ref. 2; AAI04383

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AK006802
EMBL· GenBank· DDBJ
BAB24747.1
EMBL· GenBank· DDBJ
mRNA
BC087870
EMBL· GenBank· DDBJ
AAH87870.1
EMBL· GenBank· DDBJ
mRNA
BC104382
EMBL· GenBank· DDBJ
AAI04383.1
EMBL· GenBank· DDBJ
mRNA
BC104383
EMBL· GenBank· DDBJ
AAI04384.1
EMBL· GenBank· DDBJ
mRNA
BK001511
EMBL· GenBank· DDBJ
DAA01955.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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