Q6IGX9 · SIFA_DROME

Function

function

Ligand for the neuropeptide SIFamide receptor (PubMed:16378592).
Modulates sexual behavior by negatively regulating female receptivity to male courtship and by playing a role in male sex discrimination (PubMed:17126293, PubMed:26469541).
Also involved in promoting sleep (PubMed:24658384).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular space
Molecular Functionhormone activity
Molecular Functionneuropeptide hormone activity
Molecular Functionneuropeptide receptor binding
Molecular Functionreceptor ligand activity
Biological Processmating behavior, sex discrimination
Biological Processnegative regulation of female receptivity
Biological Processneuropeptide signaling pathway
Biological Processpositive regulation of circadian sleep/wake cycle, sleep
Biological Processregulation of circadian rhythm

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Neuropeptide SIFamide

Gene names

    • Name
      SIFa
    • Synonyms
      IFa
    • ORF names
      CG33527

Organism names

  • Taxonomic identifier
  • Strain
    • Berkeley
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora

Accessions

  • Primary accession
    Q6IGX9
  • Secondary accessions
    • A8E6Z0
    • A8E728
    • B3DMR1
    • Q8IA34

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Phenotypes & Variants

Disruption phenotype

RNAi-mediated knockdown in SIFa-expressing neurons causes normal male sexual activity towards virgin females but also vigorous courtship directed at other males and also leads to female hyper-receptivity with a dramatic decrease in copulation time (PubMed:17126293).
It also causes reduced sleep and shortened sleep bout length (PubMed:24658384).

PTM/Processing

Features

Showing features for signal, peptide, glycosylation, modified residue, propeptide.

TypeIDPosition(s)Description
Signal1-26
PeptidePRO_500674650827-38Neuropeptide SIFamide
Glycosylation34N-linked (GlcNAc...) asparagine
Modified residue38Phenylalanine amide
PropeptidePRO_000043620642-72

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Strongly expressed in two pairs of neurons in the pars intercerebralis (at protein level).

Gene expression databases

Interaction

Protein-protein interaction databases

Family & Domains

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    72
  • Mass (Da)
    7,901
  • Last updated
    2004-07-05 v1
  • Checksum
    B832A1D73BE93977
MALRFTLTLLLVTILVAAILLGSSEAAYRKPPFNGSIFGKRNSLDYDSAKMSAVCEVAMEACPMWFPQNDSK

Sequence caution

The sequence AAO15386.1 differs from that shown. Reason: Miscellaneous discrepancy Probably cloning artifact.
The sequence ABV82314.1 differs from that shown. Reason: Erroneous initiation Extended N-terminus.
The sequence ABV82352.1 differs from that shown. Reason: Erroneous initiation Extended N-terminus.
The sequence ACD81713.1 differs from that shown. Reason: Erroneous initiation Extended N-terminus.

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF376801
EMBL· GenBank· DDBJ
AAO15386.1
EMBL· GenBank· DDBJ
mRNA Sequence problems.
AE013599
EMBL· GenBank· DDBJ
AFH08249.1
EMBL· GenBank· DDBJ
Genomic DNA
BT030932
EMBL· GenBank· DDBJ
ABV82314.1
EMBL· GenBank· DDBJ
mRNA Different initiation
BT030951
EMBL· GenBank· DDBJ
ABV82333.1
EMBL· GenBank· DDBJ
mRNA
BT030970
EMBL· GenBank· DDBJ
ABV82352.1
EMBL· GenBank· DDBJ
mRNA Different initiation
BT032699
EMBL· GenBank· DDBJ
ACD81713.1
EMBL· GenBank· DDBJ
mRNA Different initiation
BK003637
EMBL· GenBank· DDBJ
DAA02335.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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