Q6IE81 · JADE1_HUMAN
- ProteinProtein Jade-1
- GeneJADE1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids842 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Scaffold subunit of some HBO1 complexes, which have a histone H4 acetyltransferase activity (PubMed:16387653, PubMed:19187766, PubMed:20129055, PubMed:24065767).
Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H4 acetylation (H4K5ac, H4K8ac and H4K12ac), regulating DNA replication initiation, regulating DNA replication initiation (PubMed:20129055, PubMed:24065767).
May also promote acetylation of nucleosomal histone H4 by KAT5 (PubMed:15502158).
Promotes apoptosis (PubMed:16046545).
May act as a renal tumor suppressor (PubMed:16046545).
Negatively regulates canonical Wnt signaling; at least in part, cooperates with NPHP4 in this function (PubMed:22654112).
Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H4 acetylation (H4K5ac, H4K8ac and H4K12ac), regulating DNA replication initiation, regulating DNA replication initiation (PubMed:20129055, PubMed:24065767).
May also promote acetylation of nucleosomal histone H4 by KAT5 (PubMed:15502158).
Promotes apoptosis (PubMed:16046545).
May act as a renal tumor suppressor (PubMed:16046545).
Negatively regulates canonical Wnt signaling; at least in part, cooperates with NPHP4 in this function (PubMed:22654112).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | centrosome | |
Cellular Component | ciliary basal body | |
Cellular Component | cytoplasm | |
Cellular Component | cytosol | |
Cellular Component | histone acetyltransferase complex | |
Cellular Component | nuclear speck | |
Cellular Component | nucleoplasm | |
Cellular Component | nucleus | |
Cellular Component | plasma membrane | |
Molecular Function | metal ion binding | |
Molecular Function | transcription coactivator activity | |
Biological Process | apoptotic process | |
Biological Process | chromatin remodeling | |
Biological Process | negative regulation of canonical Wnt signaling pathway | |
Biological Process | negative regulation of cell growth | |
Biological Process | negative regulation of G1/S transition of mitotic cell cycle | |
Biological Process | regulation of cell cycle | |
Biological Process | regulation of cell growth | |
Biological Process | regulation of DNA biosynthetic process | |
Biological Process | regulation of DNA replication | |
Biological Process | regulation of DNA-templated transcription | |
Biological Process | regulation of transcription by RNA polymerase II |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameProtein Jade-1
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ6IE81
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Note: Localizes to the ciliary transition zone.
Keywords
- Cellular component
Disease & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_053777 | 662 | in dbSNP:rs6855813 | |||
Sequence: N → S |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 740 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for chain, modified residue, modified residue (large scale data), cross-link.
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Chain | PRO_0000253529 | 1-842 | UniProt | Protein Jade-1 | |||
Sequence: MKRGRLPSSSEDSDDNGSLSTTWSQNSRSQHRRSSCSRHEDRKPSEVFRTDLITAMKLHDSYQLNPDEYYVLADPWRQEWEKGVQVPVSPGTIPQPVARVVSEEKSLMFIRPKKYIVSSGSEPPELGYVDIRTLADSVCRYDLNDMDAAWLELTNEEFKEMGMPELDEYTMERVLEEFEQRCYDNMNHAIETEEGLGIEYDEDVVCDVCQSPDGEDGNEMVFCDKCNICVHQACYGILKVPEGSWLCRTCALGVQPKCLLCPKKGGAMKPTRSGTKWVHVSCALWIPEVSIGSPEKMEPITKVSHIPSSRWALVCSLCNEKFGASIQCSVKNCRTAFHVTCAFDRGLEMKTILAENDEVKFKSYCPKHSSHRKPEESLGKGAAQENGAPECSPRNPLEPFASLEQNREEAHRVSVRKQKLQQLEDEFYTFVNLLDVARALRLPEEVVDFLYQYWKLKRKVNFNKPLITPKKDEEDNLAKREQDVLFRRLQLFTHLRQDLERVRNLTYMVTRREKIKRSVCKVQEQIFNLYTKLLEQERVSGVPSSCSSSSLENMLLFNSPSVGPDAPKIEDLKWHSAFFRKQMGTSLVHSLKKPHKRDPLQNSPGSEGKTLLKQPDLCGRREGMVVPESFLGLEKTFAEARLISAQQKNGVVMPDHGKRRDNRFHCDLIKGDLKDKSFKQSHKPLRSTDVSQRHLDNTRAATSPGVGQSAPGTRKEIVPKCNGSLIKVNYNQTAVKVPTTPASPVKNWGGFRIPKKGERQQQGEAHDGACHQHSDYPYLGLGRVPAKERAKSKLKSDNENDGYVPDVEMSDSESEASEKKCIHTSSTISRRTDIIRRSILAS | |||||||
Modified residue | 89 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 89 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue | 92 | UniProt | Phosphothreonine | ||||
Sequence: T | |||||||
Cross-link | 114 | UniProt | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) | ||||
Sequence: K | |||||||
Modified residue (large scale data) | 293 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 392 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 468 | PRIDE | Phosphothreonine | ||||
Sequence: T | |||||||
Cross-link | 573 | UniProt | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) | ||||
Sequence: K | |||||||
Modified residue | 603 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 603 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 606 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue | 609 | UniProt | N6-acetyllysine | ||||
Sequence: K | |||||||
Modified residue | 703 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 703 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 740 | PRIDE | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue | 743 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 743 | PRIDE | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Highly expressed in kidney. Also present in pancreas, liver and heart (at protein level). Down-regulated in renal cancer cells.
Gene expression databases
Organism-specific databases
Interaction
Subunit
Component of the HBO1 complex composed at least of ING4 or ING5, KAT7/HBO1, MEAF6, and one of JADE1, JADE2 and JADE3 (PubMed:16387653, PubMed:19187766, PubMed:20129055, PubMed:24065767, PubMed:29382722).
Interacts with NPHP4 (PubMed:22654112).
Interacts with NPHP4 (PubMed:22654112).
Isoform 3
Interacts with VHL and KAT5 (PubMed:12169691, PubMed:15502158).
Does not associate with ING4 or ING5, and does not act as a component of the HBO1 complex (PubMed:19187766).
Does not associate with ING4 or ING5, and does not act as a component of the HBO1 complex (PubMed:19187766).
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | Q6IE81 | KAT7 O95251 | 4 | EBI-954672, EBI-473199 | |
BINARY | Q6IE81 | NPHP4 O75161 | 4 | EBI-954672, EBI-4281852 | |
BINARY | Q6IE81 | YJU2 Q9BW85 | 3 | EBI-954672, EBI-10300345 | |
BINARY | Q6IE81-3 | OPTN Q96CV9 | 3 | EBI-12120084, EBI-748974 | |
BINARY | Q6IE81-3 | YJU2 Q9BW85 | 3 | EBI-12120084, EBI-10300345 | |
BINARY | Q6IE81-3 | ZNF148 Q9UQR1-2 | 3 | EBI-12120084, EBI-11742222 |
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for region, compositional bias, zinc finger.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-43 | Disordered | ||||
Sequence: MKRGRLPSSSEDSDDNGSLSTTWSQNSRSQHRRSSCSRHEDRK | ||||||
Compositional bias | 11-31 | Polar residues | ||||
Sequence: EDSDDNGSLSTTWSQNSRSQH | ||||||
Region | 60-80 | Interaction with KAT7/HBO1 and histones | ||||
Sequence: DSYQLNPDEYYVLADPWRQEW | ||||||
Region | 80-188 | Interaction with histones | ||||
Sequence: WEKGVQVPVSPGTIPQPVARVVSEEKSLMFIRPKKYIVSSGSEPPELGYVDIRTLADSVCRYDLNDMDAAWLELTNEEFKEMGMPELDEYTMERVLEEFEQRCYDNMNH | ||||||
Zinc finger | 203-253 | PHD-type 1 | ||||
Sequence: DVVCDVCQSPDGEDGNEMVFCDKCNICVHQACYGILKVPEGSWLCRTCALG | ||||||
Zinc finger | 255-289 | C2HC pre-PHD-type | ||||
Sequence: QPKCLLCPKKGGAMKPTRSGTKWVHVSCALWIPEV | ||||||
Zinc finger | 313-369 | PHD-type 2 | ||||
Sequence: LVCSLCNEKFGASIQCSVKNCRTAFHVTCAFDRGLEMKTILAENDEVKFKSYCPKHS | ||||||
Region | 366-398 | Disordered | ||||
Sequence: PKHSSHRKPEESLGKGAAQENGAPECSPRNPLE | ||||||
Region | 589-613 | Disordered | ||||
Sequence: HSLKKPHKRDPLQNSPGSEGKTLLK | ||||||
Compositional bias | 678-693 | Basic and acidic residues | ||||
Sequence: FKQSHKPLRSTDVSQR | ||||||
Region | 678-715 | Disordered | ||||
Sequence: FKQSHKPLRSTDVSQRHLDNTRAATSPGVGQSAPGTRK | ||||||
Compositional bias | 694-709 | Polar residues | ||||
Sequence: HLDNTRAATSPGVGQS | ||||||
Compositional bias | 787-802 | Basic and acidic residues | ||||
Sequence: KERAKSKLKSDNENDG | ||||||
Region | 787-825 | Disordered | ||||
Sequence: KERAKSKLKSDNENDGYVPDVEMSDSESEASEKKCIHTS |
Domain
The 2 PHD-type zinc fingers are required for transcriptional activity.
Sequence similarities
Belongs to the JADE family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoforms
- Sequence statusComplete
This entry describes 3 isoforms produced by Alternative splicing.
Q6IE81-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- SynonymsJADE1L
- Length842
- Mass (Da)95,533
- Last updated2004-07-05 v1
- Checksum239FC2229CE25FFD
Q6IE81-2
- Name2
- Differences from canonical
- 99-110: Missing
Q6IE81-3
- Name3
- SynonymsJADE1S
Computationally mapped potential isoform sequences
There are 7 potential isoforms mapped to this entry
Sequence caution
Features
Showing features for compositional bias, alternative sequence.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 11-31 | Polar residues | ||||
Sequence: EDSDDNGSLSTTWSQNSRSQH | ||||||
Alternative sequence | VSP_021045 | 99-110 | in isoform 2 | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_021046 | 503-509 | in isoform 3 | |||
Sequence: RNLTYMV → MIDTDTL | ||||||
Alternative sequence | VSP_021047 | 510-842 | in isoform 3 | |||
Sequence: Missing | ||||||
Compositional bias | 678-693 | Basic and acidic residues | ||||
Sequence: FKQSHKPLRSTDVSQR | ||||||
Compositional bias | 694-709 | Polar residues | ||||
Sequence: HLDNTRAATSPGVGQS | ||||||
Compositional bias | 787-802 | Basic and acidic residues | ||||
Sequence: KERAKSKLKSDNENDG |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF520952 EMBL· GenBank· DDBJ | AAM95612.1 EMBL· GenBank· DDBJ | mRNA | ||
AK027620 EMBL· GenBank· DDBJ | BAB55239.1 EMBL· GenBank· DDBJ | mRNA | ||
AK026132 EMBL· GenBank· DDBJ | BAB15371.1 EMBL· GenBank· DDBJ | mRNA | Different initiation | |
AK074986 EMBL· GenBank· DDBJ | BAC11335.1 EMBL· GenBank· DDBJ | mRNA | Different initiation | |
AK127326 EMBL· GenBank· DDBJ | BAC86931.1 EMBL· GenBank· DDBJ | mRNA | ||
AC108024 EMBL· GenBank· DDBJ | AAY40997.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AC093783 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CH471056 EMBL· GenBank· DDBJ | EAX05171.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CH471056 EMBL· GenBank· DDBJ | EAX05173.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CH471056 EMBL· GenBank· DDBJ | EAX05175.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CH471056 EMBL· GenBank· DDBJ | EAX05176.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC032376 EMBL· GenBank· DDBJ | AAH32376.1 EMBL· GenBank· DDBJ | mRNA | ||
AB058710 EMBL· GenBank· DDBJ | BAB47436.1 EMBL· GenBank· DDBJ | mRNA | ||
BN000287 EMBL· GenBank· DDBJ | CAE30500.1 EMBL· GenBank· DDBJ | mRNA |