Q6IE81 · JADE1_HUMAN

  • Protein
    Protein Jade-1
  • Gene
    JADE1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Scaffold subunit of some HBO1 complexes, which have a histone H4 acetyltransferase activity (PubMed:16387653, PubMed:19187766, PubMed:20129055, PubMed:24065767).
Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H4 acetylation (H4K5ac, H4K8ac and H4K12ac), regulating DNA replication initiation, regulating DNA replication initiation (PubMed:20129055, PubMed:24065767).
May also promote acetylation of nucleosomal histone H4 by KAT5 (PubMed:15502158).
Promotes apoptosis (PubMed:16046545).
May act as a renal tumor suppressor (PubMed:16046545).
Negatively regulates canonical Wnt signaling; at least in part, cooperates with NPHP4 in this function (PubMed:22654112).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcentrosome
Cellular Componentciliary basal body
Cellular Componentcytoplasm
Cellular Componentcytosol
Cellular Componenthistone acetyltransferase complex
Cellular Componentnuclear speck
Cellular Componentnucleoplasm
Cellular Componentnucleus
Cellular Componentplasma membrane
Molecular Functionmetal ion binding
Molecular Functiontranscription coactivator activity
Biological Processapoptotic process
Biological Processchromatin remodeling
Biological Processnegative regulation of canonical Wnt signaling pathway
Biological Processnegative regulation of cell growth
Biological Processnegative regulation of G1/S transition of mitotic cell cycle
Biological Processregulation of cell cycle
Biological Processregulation of cell growth
Biological Processregulation of DNA biosynthetic process
Biological Processregulation of DNA replication
Biological Processregulation of DNA-templated transcription
Biological Processregulation of transcription by RNA polymerase II

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Protein Jade-1
  • Alternative names
    • Jade family PHD finger protein 1
    • PHD finger protein 17

Gene names

    • Name
      JADE1
    • Synonyms
      KIAA1807, PHF17

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q6IE81
  • Secondary accessions
    • D3DNY0
    • D3DNY1
    • Q4W5D5
    • Q6ZSL7
    • Q8NC41

Proteomes

Organism-specific databases

Subcellular Location

Disease & Variants

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variantVAR_053777662in dbSNP:rs6855813

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 740 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for chain, modified residue, modified residue (large scale data), cross-link.

TypeIDPosition(s)SourceDescription
ChainPRO_00002535291-842UniProtProtein Jade-1
Modified residue89UniProtPhosphoserine
Modified residue (large scale data)89PRIDEPhosphoserine
Modified residue92UniProtPhosphothreonine
Cross-link114UniProtGlycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)
Modified residue (large scale data)293PRIDEPhosphoserine
Modified residue (large scale data)392PRIDEPhosphoserine
Modified residue (large scale data)468PRIDEPhosphothreonine
Cross-link573UniProtGlycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)
Modified residue603UniProtPhosphoserine
Modified residue (large scale data)603PRIDEPhosphoserine
Modified residue (large scale data)606PRIDEPhosphoserine
Modified residue609UniProtN6-acetyllysine
Modified residue703UniProtPhosphoserine
Modified residue (large scale data)703PRIDEPhosphoserine
Modified residue (large scale data)740PRIDEPhosphothreonine
Modified residue743UniProtPhosphoserine
Modified residue (large scale data)743PRIDEPhosphoserine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Highly expressed in kidney. Also present in pancreas, liver and heart (at protein level). Down-regulated in renal cancer cells.

Gene expression databases

Organism-specific databases

Interaction

Subunit

Component of the HBO1 complex composed at least of ING4 or ING5, KAT7/HBO1, MEAF6, and one of JADE1, JADE2 and JADE3 (PubMed:16387653, PubMed:19187766, PubMed:20129055, PubMed:24065767, PubMed:29382722).
Interacts with NPHP4 (PubMed:22654112).

Isoform 3

Interacts with VHL and KAT5 (PubMed:12169691, PubMed:15502158).
Does not associate with ING4 or ING5, and does not act as a component of the HBO1 complex (PubMed:19187766).

Binary interactions

View interactors in UniProtKB
View CPX-718 in Complex Portal

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for region, compositional bias, zinc finger.

TypeIDPosition(s)Description
Region1-43Disordered
Compositional bias11-31Polar residues
Region60-80Interaction with KAT7/HBO1 and histones
Region80-188Interaction with histones
Zinc finger203-253PHD-type 1
Zinc finger255-289C2HC pre-PHD-type
Zinc finger313-369PHD-type 2
Region366-398Disordered
Region589-613Disordered
Compositional bias678-693Basic and acidic residues
Region678-715Disordered
Compositional bias694-709Polar residues
Compositional bias787-802Basic and acidic residues
Region787-825Disordered

Domain

The 2 PHD-type zinc fingers are required for transcriptional activity.

Sequence similarities

Belongs to the JADE family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoforms

Align isoforms (3)
  • Sequence status
    Complete

This entry describes 3 isoforms produced by Alternative splicing.

Q6IE81-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Name
    1
  • Synonyms
    JADE1L
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Length
    842
  • Mass (Da)
    95,533
  • Last updated
    2004-07-05 v1
  • Checksum
    239FC2229CE25FFD
MKRGRLPSSSEDSDDNGSLSTTWSQNSRSQHRRSSCSRHEDRKPSEVFRTDLITAMKLHDSYQLNPDEYYVLADPWRQEWEKGVQVPVSPGTIPQPVARVVSEEKSLMFIRPKKYIVSSGSEPPELGYVDIRTLADSVCRYDLNDMDAAWLELTNEEFKEMGMPELDEYTMERVLEEFEQRCYDNMNHAIETEEGLGIEYDEDVVCDVCQSPDGEDGNEMVFCDKCNICVHQACYGILKVPEGSWLCRTCALGVQPKCLLCPKKGGAMKPTRSGTKWVHVSCALWIPEVSIGSPEKMEPITKVSHIPSSRWALVCSLCNEKFGASIQCSVKNCRTAFHVTCAFDRGLEMKTILAENDEVKFKSYCPKHSSHRKPEESLGKGAAQENGAPECSPRNPLEPFASLEQNREEAHRVSVRKQKLQQLEDEFYTFVNLLDVARALRLPEEVVDFLYQYWKLKRKVNFNKPLITPKKDEEDNLAKREQDVLFRRLQLFTHLRQDLERVRNLTYMVTRREKIKRSVCKVQEQIFNLYTKLLEQERVSGVPSSCSSSSLENMLLFNSPSVGPDAPKIEDLKWHSAFFRKQMGTSLVHSLKKPHKRDPLQNSPGSEGKTLLKQPDLCGRREGMVVPESFLGLEKTFAEARLISAQQKNGVVMPDHGKRRDNRFHCDLIKGDLKDKSFKQSHKPLRSTDVSQRHLDNTRAATSPGVGQSAPGTRKEIVPKCNGSLIKVNYNQTAVKVPTTPASPVKNWGGFRIPKKGERQQQGEAHDGACHQHSDYPYLGLGRVPAKERAKSKLKSDNENDGYVPDVEMSDSESEASEKKCIHTSSTISRRTDIIRRSILAS

Q6IE81-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Q6IE81-3

  • Name
    3
  • Synonyms
    JADE1S
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Computationally mapped potential isoform sequences

There are 7 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
D6RFK0D6RFK0_HUMANJADE1136
D6RGE7D6RGE7_HUMANJADE1143
D6RC05D6RC05_HUMANJADE1129
D6RAS5D6RAS5_HUMANJADE149
D6RBB3D6RBB3_HUMANJADE1131
D6RE74D6RE74_HUMANJADE117
D6RCS1D6RCS1_HUMANJADE1119

Sequence caution

The sequence BAB15371.1 differs from that shown. Reason: Erroneous initiation Truncated N-terminus.
The sequence BAC11335.1 differs from that shown. Reason: Erroneous initiation Truncated N-terminus.

Features

Showing features for compositional bias, alternative sequence.

TypeIDPosition(s)Description
Compositional bias11-31Polar residues
Alternative sequenceVSP_02104599-110in isoform 2
Alternative sequenceVSP_021046503-509in isoform 3
Alternative sequenceVSP_021047510-842in isoform 3
Compositional bias678-693Basic and acidic residues
Compositional bias694-709Polar residues
Compositional bias787-802Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF520952
EMBL· GenBank· DDBJ
AAM95612.1
EMBL· GenBank· DDBJ
mRNA
AK027620
EMBL· GenBank· DDBJ
BAB55239.1
EMBL· GenBank· DDBJ
mRNA
AK026132
EMBL· GenBank· DDBJ
BAB15371.1
EMBL· GenBank· DDBJ
mRNA Different initiation
AK074986
EMBL· GenBank· DDBJ
BAC11335.1
EMBL· GenBank· DDBJ
mRNA Different initiation
AK127326
EMBL· GenBank· DDBJ
BAC86931.1
EMBL· GenBank· DDBJ
mRNA
AC108024
EMBL· GenBank· DDBJ
AAY40997.1
EMBL· GenBank· DDBJ
Genomic DNA
AC093783
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
CH471056
EMBL· GenBank· DDBJ
EAX05171.1
EMBL· GenBank· DDBJ
Genomic DNA
CH471056
EMBL· GenBank· DDBJ
EAX05173.1
EMBL· GenBank· DDBJ
Genomic DNA
CH471056
EMBL· GenBank· DDBJ
EAX05175.1
EMBL· GenBank· DDBJ
Genomic DNA
CH471056
EMBL· GenBank· DDBJ
EAX05176.1
EMBL· GenBank· DDBJ
Genomic DNA
BC032376
EMBL· GenBank· DDBJ
AAH32376.1
EMBL· GenBank· DDBJ
mRNA
AB058710
EMBL· GenBank· DDBJ
BAB47436.1
EMBL· GenBank· DDBJ
mRNA
BN000287
EMBL· GenBank· DDBJ
CAE30500.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp