Q6IE24 · UBP54_RAT

  • Protein
    Ubiquitin carboxyl-terminal hydrolase 54
  • Gene
    Usp54
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    3/5

Function

function

Deubiquitinating enzyme which mediates deubiquitination of PLK4, maintaining PLK4 stability by reducing its ubiquitination-mediated degradation.

Catalytic activity

  • Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
    EC:3.4.19.12 (UniProtKB | ENZYME | Rhea)

Features

Showing features for active site.

115882004006008001,0001,2001,400
TypeIDPosition(s)Description
Active site42Nucleophile
Active site302Proton acceptor

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Molecular Functioncysteine-type deubiquitinase activity
Biological Processprotein deubiquitination
Biological Processproteolysis

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Ubiquitin carboxyl-terminal hydrolase 54
  • EC number
  • Alternative names
    • Ubiquitin-specific peptidase 54

Gene names

    • Name
      Usp54

Organism names

  • Taxonomic identifier
  • Strain
    • Brown Norway
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    Q6IE24
  • Secondary accessions
    • Q4QQU8

Proteomes

Organism-specific databases

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00002495321-1588Ubiquitin carboxyl-terminal hydrolase 54
Modified residue12Omega-N-methylarginine
Modified residue424Phosphoserine
Modified residue574Phosphoserine
Modified residue613Phosphoserine
Modified residue616Phosphoserine
Modified residue1138Phosphoserine

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, compositional bias, region, coiled coil.

TypeIDPosition(s)Description
Domain31-352USP
Compositional bias380-418Basic and acidic residues
Region380-447Disordered
Compositional bias459-474Polar residues
Region459-519Disordered
Compositional bias495-515Polar residues
Region601-620Disordered
Compositional bias603-617Polar residues
Coiled coil678-712
Region801-839Disordered
Region856-895Disordered
Compositional bias874-895Polar residues
Region950-969Disordered
Compositional bias1093-1119Polar residues
Region1093-1172Disordered
Region1525-1562Disordered

Sequence similarities

Belongs to the peptidase C19 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

Q6IE24-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    1,588
  • Mass (Da)
    176,155
  • Last updated
    2008-11-25 v2
  • Checksum
    582B9DD5DE9B6916
MSWKRNYFSGGRGSVQGMFAPRSSMSIAPSKGLSNEPGQNSCFLNSALQVLWHLDIFRRSFRQLTSHKCMGDSCIFCALKGIFKQFQCSSEKVLPSDTLRSALAKTFQDEQRFQLGIMDDAAECFENLLMRIHFHIADETKEDICTAPHCISHQKFAMTLFEQCVCTSCGATSDPLPFIQMVHYISTTSLCNQAICMLEKREKPSPGMFGELLQNASTMGDLRDCPSNCGERIRIRRVLMNAPQIITIGLVWDSDHSDLAEDVIHSLGTCLKLGDLFFRVTDDRAKQSELYLVGMICYYGKHYSTFFFQTKIRKWMYFDDAHVKEIGPKWKDVVTKCIKGHYQPLLLLYADPQGTPVSAQDLPPHAQLLSHTKTCYDSEDSGHLTDSECNQKHTTKKGPLVERRRGSGRIRRKADAPQASGYHSEGETLKEKQAPRNASKSSSTSRLKDFKETVSNMIHSRPSLASQTNAASPCVGRAGDQPDKIPARNLPLHSRGWETESTSSEARSSSSSKYRPTWRPKRESLNIDSIFSKDKRKHCGYTQLKTFPEDAAKEFAQDEVSNPVANDIKDGGPSSQHKLWGTARPGSHLLEQHPRLIQRMESGYESSERNSSSPVSLDAAPPECLNVYRDQSTKRAVGFVPSWRHIPKSHSSSILEVDSTAPVTGWTETQPFSDGEITSKSELDELQEEVARRAQEQELRKKREKELEAAKGFNPHPSRYMDLDELQNQGRSDGFERSLQEANSVFEESLHLEQEGDCAAALALCNEAISKLRLTLHDASSSTHSRALVDKKLQISIRKARSLQDRMQQQPPSQQPVQPSASLPSQGGGLPQPTSEQSVPLQVLLSQQTQLEPCKDSELGATSPFFHSPASCPEPHSSLVSPSPAQSVSQHSPPGTSALKLLKSFEVDIVNHSAFHRQDLPKATGRTEMNSQHECLPFDALEDRLQGHREDNSCCSKFPPQEGRDTTQDQLLEGRKTPVDISMGMPWSHSAGGATSERVMHSLNSPSSPSAQPAVPPYGACHPIMSAAASPVLHAADPMQKLNQHLQAQSLQTSLASKVVRGSEEPYRPEFPSTKGLVRSLAEQFQKIRNTSTRDVIGSQDRSLPNGLRKSSSPSDFMLPLSQGPEKEHCRWVNQPPSPDGRERQPCWEEPAGHPSVSIDSGLPNGEASRRRQPRLAEADIYQGKLPQVTDTRPTELGSSVSLGTSLPLDSWVNVTRLCDSQVKHRAPGLGVKSSSHDSRTCVTYPERNPILLHPHWNQDTEQETSELESLYQASLQASSHTGYSDWRSQDVAWQPLSLTGSADGMGRRLHSAPGLDLSKTPTAEMERILYEPSTVPVSQDSSNVRKKTLETGHHCSSSSSLPVIHDPPVFLLDPKLYPPQPQFLSPDVLMPSMAGEPYRSPGTSRSVQQFLAMCDRDETPQGVKYTGRTLNYRSLPHRSRTDASWGPGTETNQHIGARVLTAPACKPQLTYTATLPERHQGLQVPHAQSWGNLFHLPSHPSAVHPGSPPSSSLHVLHRSSWNSGSVLGSRTPGPRRIDVPPDDDGRQSQYPSQYRHRSAGEERVRFALSNTAGTEQSRVRLLQHSRW

Q6IE24-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 383-446: HLTDSECNQKHTTKKGPLVERRRGSGRIRRKADAPQASGYHSEGETLKEKQAPRNASKSSSTSR → EQLSSPATPYSPMVGSHTQVSTELGERGSVTVREKGQPVCTQLIPIRLVFLCFQSVLLKSAGLK
    • 447-1588: Missing

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A0G2JTN3A0A0G2JTN3_RATUsp541645

Features

Showing features for compositional bias, alternative sequence, sequence conflict.

TypeIDPosition(s)Description
Compositional bias380-418Basic and acidic residues
Alternative sequenceVSP_035681383-446in isoform 2
Alternative sequenceVSP_035682447-1588in isoform 2
Compositional bias459-474Polar residues
Compositional bias495-515Polar residues
Compositional bias603-617Polar residues
Compositional bias874-895Polar residues
Compositional bias1093-1119Polar residues
Sequence conflict1502in Ref. 2; AAH97982

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AABR03094963
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
BC097982
EMBL· GenBank· DDBJ
AAH97982.1
EMBL· GenBank· DDBJ
mRNA
BN000369
EMBL· GenBank· DDBJ
CAE51895.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp