Q6IDB6 · TAD2_ARATH

Function

function

Involved in RNA editing. Catalyzes the specific deamination of adenosine-34 in several cytosolic tRNA species. Generates inosine at the wobble position of the anticodon loop.

Catalytic activity

Features

Showing features for binding site, active site.

118220406080100120140160180
TypeIDPosition(s)Description
Binding site58Zn2+ (UniProtKB | ChEBI); catalytic
Active site60Proton donor
Binding site97Zn2+ (UniProtKB | ChEBI); catalytic
Binding site100Zn2+ (UniProtKB | ChEBI); catalytic

GO annotations

all annotationsall molecular functionnucleotide bindingmolecular_functionnucleic acid bindingdna bindingchromatin bindingdna-binding transcription factor activityrna bindingcytoskeletal motor activitycatalytic activitynuclease activitysignaling receptor bindingstructural molecule activitytransporter activitybindingprotein bindingtranslation factor activity, rna bindinglipid bindingkinase activitytransferase activityhydrolase activityoxygen bindingenzyme regulator activitycarbohydrate bindingsignaling receptor activitytranslation regulator activitytranscription regulator activityother molecular functionall biological processcarbohydrate metabolic processgeneration of precursor metabolites and energynucleobase-containing compound metabolic processdna metabolic processtranslationlipid metabolic processtransportresponse to stresscell cyclecell communicationsignal transductioncell-cell signalingmulticellular organism developmentcircadian rhythmbiological_processmetabolic processcatabolic processbiosynthetic processresponse to light stimulusresponse to external stimulustropismresponse to biotic stimulusresponse to abiotic stimulusresponse to endogenous stimulusembryo developmentpost-embryonic developmentfruit ripeningabscissionpollinationflower developmentcellular processprogrammed cell deathphotosynthesiscellular component organizationcell growthprotein metabolic processcellular homeostasissecondary metabolic processreproductive processcell differentiationprotein modification processgrowthepigenetic regulation of gene expressionresponse to chemicalanatomical structure developmentregulation of molecular functionother biological processall cellular componentcellular_componentextracellular regioncell wallintracellular anatomical structurenucleusnuclear envelopenucleoplasmnucleoluscytoplasmmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuscytosolribosomecytoskeletonplasma membranechloroplastplastidthylakoidmembraneexternal encapsulating structureother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentnucleus
Molecular FunctiontRNA-specific adenosine deaminase activity
Molecular FunctiontRNA-specific adenosine-34 deaminase activity
Molecular Functionzinc ion binding
Biological ProcesstRNA modification
Biological ProcesstRNA wobble adenosine to inosine editing

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    tRNA-specific adenosine deaminase TAD2
  • EC number
  • Short names
    AtTAD2
  • Alternative names
    • Protein EMBRYO DEFECTIVE 2191
    • tRNA-specific adenosine-34 deaminase TAD2

Gene names

    • Name
      TAD2
    • Synonyms
      EMB2191
    • ORF names
      F21D18.9
    • Ordered locus names
      At1g48175

Organism names

  • Taxonomic identifier
  • Strain
    • cv. Columbia
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis

Accessions

  • Primary accession
    Q6IDB6
  • Secondary accessions
    • Q9LNH1

Proteomes

Organism-specific databases

Genome annotation databases

Subcellular Location

Nucleus
Cytoplasm
Note: Localizes predominantly to the nucleus.

Keywords

Phenotypes & Variants

Disruption phenotype

Embryonic lethality due to embryo development arrest at the globular stage.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 18 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004438591-182tRNA-specific adenosine deaminase TAD2

Proteomic databases

Expression

Gene expression databases

Interaction

Subunit

Interacts with TAD3.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain7-135CMP/dCMP-type deaminase

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    182
  • Mass (Da)
    20,107
  • Last updated
    2004-07-05 v1
  • Checksum
    E8B97E09AC156050
MEEDHCEDSHNYMGFALHQAKLALEALEVPVGCVFLEDGKVIASGRNRTNETRNATRHAEMEAIDQLVGQWQKDGLSPSQVAEKFSKCVLYVTCEPCIMCASALSFLGIKEVYYGCPNDKFGGCGSILSLHLGSEEAQRGKGYKCRGGIMAEEAVSLFKCFYEQGNPNAPKPHRPVVQRERT

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A1P8AR49A0A1P8AR49_ARATHEMB2191167

Sequence caution

The sequence AAF79540.1 differs from that shown. Reason: Erroneous gene model prediction

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AC023673
EMBL· GenBank· DDBJ
AAF79540.1
EMBL· GenBank· DDBJ
Genomic DNA Sequence problems.
CP002684
EMBL· GenBank· DDBJ
AEE32259.1
EMBL· GenBank· DDBJ
Genomic DNA
CP002684
EMBL· GenBank· DDBJ
ANM59127.1
EMBL· GenBank· DDBJ
Genomic DNA
BT014757
EMBL· GenBank· DDBJ
AAT41740.1
EMBL· GenBank· DDBJ
mRNA
BT014997
EMBL· GenBank· DDBJ
AAT70448.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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