Q6I7B0 · MYG_AUXRO

Function

function

Monomeric heme protein which primary function is to store oxygen and facilitate its diffusion within muscle tissues. Reversibly binds oxygen through a pentacoordinated heme iron and enables its timely and efficient release as needed during periods of heightened demand. Depending on the oxidative conditions of tissues and cells, and in addition to its ability to bind oxygen, it also has a nitrite reductase activity whereby it regulates the production of bioactive nitric oxide. Under stress conditions, like hypoxia and anoxia, it also protects cells against reactive oxygen species thanks to its pseudoperoxidase activity.

Catalytic activity

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site60nitrite (UniProtKB | ChEBI)
Binding site60O2 (UniProtKB | ChEBI)
Binding site89Fe (UniProtKB | ChEBI) of heme b (UniProtKB | ChEBI); proximal binding residue

GO annotations

AspectTerm
Cellular Componentextracellular exosome
Cellular Componentsarcoplasm
Molecular Functionheme binding
Molecular Functionmetal ion binding
Molecular Functionnitrite reductase activity
Molecular Functionoxygen binding
Molecular Functionoxygen carrier activity
Molecular Functionperoxidase activity
Biological Processremoval of superoxide radicals

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Myoglobin
  • Alternative names
    • Nitrite reductase MB
      (EC:1.7.-.-
      ) . EC:1.7.-.- (UniProtKB | ENZYME | Rhea)
    • Pseudoperoxidase MB
      (EC:1.11.1.-
      ) . EC:1.11.1.- (UniProtKB | ENZYME | Rhea)

Gene names

    • Name
      mb

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Pelagiaria > Scombriformes > Scombridae > Auxis

Accessions

  • Primary accession
    Q6I7B0

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for initiator methionine, chain.

TypeIDPosition(s)Description
Initiator methionine1Removed
ChainPRO_00000533592-147Myoglobin

Interaction

Subunit

Monomeric.

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain2-141Globin

Sequence similarities

Belongs to the globin family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    147
  • Mass (Da)
    15,497
  • Last updated
    2007-01-23 v3
  • Checksum
    8993E1BDC26B768C
MADFDAVLKCWGPVEADFNTVGGMVLARLFKDHPDTQKLFPKFAGIAAGDLAGNAAVAAHGGTVLKKLGELLKAKGNHAAIIKPLANSHATKHKIPINNFKLITEALVHVMQEKAGLDAAGQTALRNVMGIVIADLEANYKELGFTG

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB154423
EMBL· GenBank· DDBJ
BAD23846.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

Disclaimer

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