Q6H6D2 · HEM3_ORYSJ

Function

function

Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.

Miscellaneous

The porphobilinogen subunits are added to the dipyrromethane group.

Catalytic activity

Cofactor

dipyrromethane (UniProtKB | Rhea| CHEBI:60342 )
Note: Binds 1 dipyrromethane group covalently.

Pathway

Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 2/4.
Porphyrin-containing compound metabolism; chlorophyll biosynthesis.

GO annotations

AspectTerm
Cellular Componentchloroplast
Cellular Componentcytoplasm
Molecular Functionhydroxymethylbilane synthase activity
Biological Processchlorophyll biosynthetic process
Biological Processchloroplast RNA modification
Biological Processheme biosynthetic process
Biological Processpeptidyl-pyrromethane cofactor linkage
Biological Processprotoporphyrinogen IX biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Porphobilinogen deaminase, chloroplastic
  • EC number
  • Short names
    PBG
  • Alternative names
    • Hydroxymethylbilane synthase (HMBS)
    • Pre-uroporphyrinogen synthase

Gene names

    • Name
      HEMC
    • ORF names
      OsJ_05540, P0669G09.15-1, P0669G09.15-2
    • Ordered locus names
      Os02g0168800, LOC_Os02g07230

Organism names

  • Taxonomic identifier
  • Strain
    • cv. Nipponbare
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > Liliopsida > Poales > Poaceae > BOP clade > Oryzoideae > Oryzeae > Oryzinae > Oryza > Oryza sativa

Accessions

  • Primary accession
    Q6H6D2
  • Secondary accessions
    • A0A0P0VF64
    • Q6H6D1

Proteomes

Genome annotation databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for signal, chain, modified residue, modified residue (large scale data).

Type
IDPosition(s)Source
Description
Signal1-24UniProt
ChainPRO_000037606625-358UniProtPorphobilinogen deaminase, chloroplastic
Modified residue290UniProtS-(dipyrrolylmethanemethyl)cysteine
Modified residue (large scale data)318PTMeXchangePhosphoserine

Proteomic databases

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the HMBS family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.

This entry describes 2 isoforms produced by Alternative splicing.

Q6H6D2-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    358
  • Mass (Da)
    38,397
  • Last updated
    2004-07-19 v1
  • Checksum
    551C55AFC7AF3943
MPPPPRCAATTAHHSLLGSPTCLARPRRRCCPVRAAVAVQAEAQAKVSLIRIGTRGSPLALAQAHETRDKLKAAHSELAEEGAVEIVIIKTTGDMILDKPLADIGGKGLFTKEIDDALLQGRIDIAVHSMKDVPTYLPEGTILPCNLPREDVRDAFICLTASSLAELPAGSVVGSASLRRQSQILYKYPSLKVVNFRGNVQTRLRKLKEGDVHATLLALAGLKRLNMAETATSVLSVDEMLPAVAQGAIGIACRSSDDTMMNYLSSLNHEDTRLAVACEREFLSVLDGNCRTPIAAYASRDKDGNCSFRGLLASPDGSTVYETSRTGPYDFDIMVEMGKDAGHELKAKAGPGFFDSLQ

Q6H6D2-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A0P0VFC8A0A0P0VFC8_ORYSJOs02g0168800303

Features

Showing features for alternative sequence.

TypeIDPosition(s)Description
Alternative sequenceVSP_0374011-94in isoform 2

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AP005071
EMBL· GenBank· DDBJ
BAD25717.1
EMBL· GenBank· DDBJ
Genomic DNA
AP005071
EMBL· GenBank· DDBJ
BAD25718.1
EMBL· GenBank· DDBJ
Genomic DNA
AP008208
EMBL· GenBank· DDBJ
BAF07931.1
EMBL· GenBank· DDBJ
Genomic DNA
AP014958
EMBL· GenBank· DDBJ
BAS77179.1
EMBL· GenBank· DDBJ
Genomic DNA
CM000139
EMBL· GenBank· DDBJ
EEE56391.1
EMBL· GenBank· DDBJ
Genomic DNA
AK060914
EMBL· GenBank· DDBJ
BAG87614.1
EMBL· GenBank· DDBJ
mRNA
AK102265
EMBL· GenBank· DDBJ
BAG95470.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp